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Calcium in PDB 6ojh: Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine

Enzymatic activity of Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine

All present enzymatic activity of Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine:
6.3.4.14; 6.4.1.2;

Protein crystallography data

The structure of Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine, PDB code: 6ojh was solved by L.D.Andrews, T.R.Kane, P.Dozzo, C.M.Haglund, D.J.Hilderbrandt, M.S.Linsell, T.Machajewski, G.Mcenroe, A.W.Serio, K.B.Wlasichuk, D.B.Neau, S.Pakhomova, G.L.Waldrop, M.Sharp, J.Pogliano, R.Cirz, F.Cohen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.69 / 2.05
Space group P 64
Cell size a, b, c (Å), α, β, γ (°) 85.688, 85.688, 104.830, 90.00, 90.00, 120.00
R / Rfree (%) 17.6 / 22.2

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine (pdb code 6ojh). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine, PDB code: 6ojh:

Calcium binding site 1 out of 1 in 6ojh

Go back to Calcium Binding Sites List in 6ojh
Calcium binding site 1 out of 1 in the Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl) Pyrido[2,3-D]Pyrimidin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca502

b:46.6
occ:1.00
 OE1 A:GLU288 2.4 37.3 1.0
OD1 A:ASN290 2.5 31.0 1.0
OXT A:ACT503 2.5 44.8 1.0
OE2 A:GLU276 2.5 38.8 1.0
O A:HOH695 2.5 32.7 1.0
O A:ACT503 2.7 45.8 1.0
C A:ACT503 3.0 50.7 1.0
CD A:GLU288 3.4 37.2 1.0
O A:HOH610 3.4 39.7 1.0
CG A:ASN290 3.4 28.7 1.0
CG A:GLU288 3.6 35.5 1.0
CD A:GLU276 3.6 35.5 1.0
ND2 A:ASN290 3.7 28.7 1.0
O A:HOH688 4.1 39.5 1.0
OE1 A:GLU276 4.2 38.9 1.0
CB A:GLU288 4.5 36.8 1.0
CH3 A:ACT503 4.5 48.3 1.0
O A:HOH654 4.5 42.4 1.0
OE2 A:GLU288 4.6 39.6 1.0
O A:MET289 4.7 30.9 1.0
CG A:GLU276 4.7 33.0 1.0
NH1 A:ARG292 4.7 30.1 0.5
CB A:ASN290 4.8 28.1 1.0
O A:HOH658 4.8 34.0 1.0
C A:MET289 4.9 30.5 1.0
O A:HOH747 4.9 35.0 1.0
N A:ASN290 5.0 29.2 1.0

Reference:

L.D.Andrews, T.R.Kane, P.Dozzo, C.M.Haglund, D.J.Hilderbrandt, M.S.Linsell, T.Machajewski, G.Mcenroe, A.W.Serio, K.B.Wlasichuk, D.B.Neau, S.Pakhomova, G.L.Waldrop, M.Sharp, J.Pogliano, R.Cirz, F.Cohen. Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-Aminopyrrolidin-1-Yl)-6-(Naphthalen-1-Yl)Pyrido[2, 3-D]Pyrimidin-2-Amine To Be Published.
Page generated: Tue Jul 16 12:33:17 2024

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