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Calcium in PDB 7lal: Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-AmineEnzymatic activity of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine
All present enzymatic activity of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine:
1.11.2.2; Protein crystallography data
The structure of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine, PDB code: 7lal
was solved by
J.A.Khan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7lal:
The structure of Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine
(pdb code 7lal). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine, PDB code: 7lal: Jump to Calcium binding site number: 1; 2; Calcium binding site 1 out of 2 in 7lalGo back to Calcium Binding Sites List in 7lal
Calcium binding site 1 out
of 2 in the Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine
Mono view Stereo pair view
Calcium binding site 2 out of 2 in 7lalGo back to Calcium Binding Sites List in 7lal
Calcium binding site 2 out
of 2 in the Crystal Structure of Myeloperoxidase Subform C (Mpo) Complex with Compound-18 Aka 7-(3-(2,3-Dihydro-1H-Inden-1-Ylamino)-1- Phenylpropyl)-1H-[1,2,3]Triazolo[4,5-B]Pyridin-5-Amine
Mono view Stereo pair view
Reference:
C.H.Hu,
M.W.Neissel Valente,
O.Scott Halpern,
S.Jusuf,
J.A.Khan,
G.A.Locke,
G.J.Duke,
X.Liu,
F.J.Duclos,
R.R.Wexler,
E.K.Kick,
J.M.Smallheer.
Small Molecule and Macrocyclic Pyrazole Derived Inhibitors of Myeloperoxidase (Mpo). Bioorg.Med.Chem.Lett. 28010 2021.
Page generated: Sat Jul 10 11:31:58 2021
ISSN: ESSN 1464-3405 PubMed: 33811992 DOI: 10.1016/J.BMCL.2021.128010 |
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