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Atomistry » Calcium » PDB 7pod-7qfy » 7pqv » |
Calcium in PDB 7pqv: MEK1 in Complex with Compound 7Enzymatic activity of MEK1 in Complex with Compound 7
All present enzymatic activity of MEK1 in Complex with Compound 7:
2.7.12.2; Protein crystallography data
The structure of MEK1 in Complex with Compound 7, PDB code: 7pqv
was solved by
H.Moebitz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7pqv:
The structure of MEK1 in Complex with Compound 7 also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the MEK1 in Complex with Compound 7
(pdb code 7pqv). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the MEK1 in Complex with Compound 7, PDB code: 7pqv: Jump to Calcium binding site number: 1; 2; Calcium binding site 1 out of 2 in 7pqvGo back to Calcium Binding Sites List in 7pqv
Calcium binding site 1 out
of 2 in the MEK1 in Complex with Compound 7
Mono view Stereo pair view
Calcium binding site 2 out of 2 in 7pqvGo back to Calcium Binding Sites List in 7pqv
Calcium binding site 2 out
of 2 in the MEK1 in Complex with Compound 7
Mono view Stereo pair view
Reference:
R.Poddutoori,
K.Aardalen,
K.Aithal,
S.S.Barahagar,
C.Belliappa,
M.Bock,
S.Chelur,
A.Gerken,
S.Gopinath,
B.Gruenenfelder,
M.Kiffe,
M.Krishnaswami,
J.Langowski,
S.Madapa,
K.Narayanan,
C.Pandit,
S.K.Panigrahi,
M.Perrone,
R.K.Potakamuri,
M.Ramachandra,
A.Ramanathan,
R.Ramos,
E.Sager,
S.Samajdar,
H.S.Subramanya,
D.S.Thimmasandra,
E.Venetsanakos,
H.Mobitz.
Discovery of MAP855, An Efficacious and Selective MEK1/2 Inhibitor with An Atp-Competitive Mode of Action. J.Med.Chem. V. 65 4350 2022.
Page generated: Fri Jul 19 03:12:52 2024
ISSN: ISSN 0022-2623 PubMed: 35195996 DOI: 10.1021/ACS.JMEDCHEM.1C02192 |
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