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Calcium in PDB 7sim: Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor

Calcium Binding Sites:

The binding sites of Calcium atom in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor (pdb code 7sim). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor, PDB code: 7sim:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in 7sim

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Calcium binding site 1 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca904

b:37.5
occ:1.00
 O A:LEU88 2.5 34.9 1.0
O A:LEU87 2.5 32.7 1.0
O A:ILE81 2.9 24.2 1.0
O A:SER84 3.1 33.8 1.0
C A:LEU88 3.2 34.9 1.0
O A:LEU91 3.6 37.5 1.0
C A:LEU87 3.7 32.7 1.0
O A:ASN82 3.7 27.4 1.0
N A:PRO89 4.0 37.1 1.0
CB A:LEU88 4.0 34.9 1.0
C A:ILE81 4.0 24.2 1.0
CA A:LEU88 4.0 34.9 1.0
CA A:ASN82 4.1 27.4 1.0
CA A:PRO89 4.1 37.1 1.0
C A:ASN82 4.2 27.4 1.0
N A:LEU88 4.3 34.9 1.0
C A:SER84 4.3 33.8 1.0
N A:ASN82 4.5 27.4 1.0
C A:PRO89 4.7 37.1 1.0
CA A:PRO85 4.8 36.4 1.0
N A:ASN90 4.8 38.7 1.0
C A:LEU91 4.8 37.5 1.0
CG2 A:ILE81 4.8 24.2 1.0
CA A:LEU87 4.9 32.7 1.0
N A:LEU91 4.9 37.5 1.0
OG A:SER84 5.0 33.8 1.0

Calcium binding site 2 out of 8 in 7sim

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Calcium binding site 2 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca905

b:39.1
occ:1.00
 OG1 A:THR100 2.7 22.0 1.0
N A:THR145 3.3 19.6 1.0
CB A:THR145 3.4 19.6 1.0
OG1 A:THR145 3.6 19.6 1.0
CB A:ALA144 3.7 17.9 1.0
CB A:THR100 3.8 22.0 1.0
CA A:THR145 3.8 19.6 1.0
N A:GLY146 4.0 20.8 1.0
OD1 A:ASN102 4.0 23.3 1.0
CG2 A:THR100 4.0 22.0 1.0
CB A:PRO39 4.1 19.9 1.0
CD A:PRO39 4.2 19.9 1.0
N A:PRO39 4.2 19.9 1.0
CG A:PRO39 4.2 19.9 1.0
CG1 A:VAL149 4.3 21.3 1.0
C A:ALA144 4.3 17.9 1.0
CA A:ASN102 4.4 23.3 1.0
CA A:ALA144 4.4 17.9 1.0
C A:THR145 4.4 19.6 1.0
N A:ASN102 4.5 23.3 1.0
C A:PHE38 4.5 17.5 1.0
CA A:PRO39 4.5 19.9 1.0
CB A:VAL149 4.7 21.3 1.0
CG2 A:THR145 4.7 19.6 1.0
CG A:ASN102 4.8 23.3 1.0
OH A:TYR167 4.8 17.2 1.0
CG2 A:VAL149 4.9 21.3 1.0
CA A:PHE38 4.9 17.5 1.0
O A:PHE38 4.9 17.5 1.0

Calcium binding site 3 out of 8 in 7sim

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Calcium binding site 3 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca906

b:35.9
occ:1.00
 OG A:SER302 2.7 27.5 1.0
CB A:SER302 3.5 27.5 1.0
CA A:GLY273 3.9 24.7 1.0
CD A:PRO274 4.0 25.2 1.0
N A:GLY273 4.1 24.7 1.0
CE1 A:PHE42 4.1 22.6 1.0
CA A:SER302 4.1 27.5 1.0
CD1 A:LEU304 4.4 26.5 1.0
O A:ALA298 4.4 23.3 1.0
CG A:LEU304 4.5 26.5 1.0
CZ3 A:TCR902 4.5 18.8 1.0
C A:GLY273 4.7 24.7 1.0
N A:PRO274 4.7 25.2 1.0
CH2 A:TCR902 4.8 18.8 1.0
CD1 A:PHE42 4.8 22.6 1.0
N A:SER303 4.9 27.8 1.0
CG A:PRO274 4.9 25.2 1.0
CZ A:PHE42 4.9 22.6 1.0
C A:SER302 4.9 27.5 1.0
NH1 A:ARG66 5.0 21.5 1.0
CB A:LEU304 5.0 26.5 1.0

Calcium binding site 4 out of 8 in 7sim

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Calcium binding site 4 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca907

b:45.5
occ:1.00
 O A:GLY557 2.4 44.3 1.0
C A:GLY557 3.5 44.3 1.0
OD2 B:ASP234 3.8 45.8 1.0
OD1 B:ASP234 3.9 45.8 1.0
CA A:GLY557 4.0 44.3 1.0
CG B:ASP234 4.2 45.8 1.0
O B:GLU231 4.4 44.1 1.0
N A:GLU558 4.5 46.0 1.0
CA A:GLU558 4.8 46.0 1.0

Calcium binding site 5 out of 8 in 7sim

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Calcium binding site 5 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca904

b:37.6
occ:1.00
 O B:LEU87 2.5 32.9 1.0
O B:LEU88 2.5 35.3 1.0
O B:SER84 3.2 33.7 1.0
O B:ILE81 3.2 24.4 1.0
C B:LEU88 3.3 35.3 1.0
O B:LEU91 3.6 37.9 1.0
O B:ASN82 3.7 28.0 1.0
C B:LEU87 3.7 32.9 1.0
N B:PRO89 4.0 38.0 1.0
CB B:LEU88 4.0 35.3 1.0
CA B:LEU88 4.0 35.3 1.0
CA B:ASN82 4.1 28.0 1.0
CA B:PRO89 4.1 38.0 1.0
C B:ASN82 4.2 28.0 1.0
C B:ILE81 4.2 24.4 1.0
N B:LEU88 4.3 35.3 1.0
C B:SER84 4.4 33.7 1.0
N B:ASN82 4.6 28.0 1.0
C B:PRO89 4.7 38.0 1.0
N B:ASN90 4.8 39.8 1.0
C B:LEU91 4.8 37.9 1.0
CG2 B:ILE81 4.8 24.4 1.0
CA B:PRO85 4.9 36.5 1.0
OD1 B:ASN82 4.9 28.0 1.0
CA B:LEU87 4.9 32.9 1.0
N B:LEU91 4.9 37.9 1.0
OG B:SER84 5.0 33.7 1.0

Calcium binding site 6 out of 8 in 7sim

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Calcium binding site 6 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca905

b:35.3
occ:1.00
 OG1 B:THR100 2.7 22.4 1.0
N B:THR145 3.3 19.6 1.0
CB B:THR145 3.4 19.6 1.0
OG1 B:THR145 3.5 19.6 1.0
CB B:ALA144 3.7 17.2 1.0
CB B:THR100 3.7 22.4 1.0
CA B:THR145 3.8 19.6 1.0
OD1 B:ASN102 3.9 22.7 1.0
N B:GLY146 4.0 21.3 1.0
CG2 B:THR100 4.0 22.4 1.0
CB B:PRO39 4.1 19.7 1.0
CG B:PRO39 4.2 19.7 1.0
CD B:PRO39 4.2 19.7 1.0
N B:PRO39 4.2 19.7 1.0
CG1 B:VAL149 4.3 21.5 1.0
C B:ALA144 4.3 17.2 1.0
CA B:ASN102 4.3 22.7 1.0
CA B:ALA144 4.4 17.2 1.0
C B:THR145 4.4 19.6 1.0
N B:ASN102 4.5 22.7 1.0
C B:PHE38 4.5 17.6 1.0
CA B:PRO39 4.6 19.7 1.0
CB B:VAL149 4.7 21.5 1.0
CG2 B:THR145 4.7 19.6 1.0
CG B:ASN102 4.8 22.7 1.0
OH B:TYR167 4.8 16.7 1.0
CG2 B:VAL149 4.9 21.5 1.0
CA B:PHE38 4.9 17.6 1.0
O B:PHE38 5.0 17.6 1.0

Calcium binding site 7 out of 8 in 7sim

Go back to Calcium Binding Sites List in 7sim
Calcium binding site 7 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca906

b:35.9
occ:1.00
 OG B:SER302 2.7 26.8 1.0
CB B:SER302 3.5 26.8 1.0
CA B:GLY273 3.9 26.6 1.0
CD B:PRO274 4.0 26.0 1.0
N B:GLY273 4.1 26.6 1.0
CA B:SER302 4.2 26.8 1.0
CE1 B:PHE42 4.2 23.1 1.0
O B:ALA298 4.4 23.3 1.0
CG B:LEU304 4.4 27.3 1.0
CD1 B:LEU304 4.5 27.3 1.0
CZ3 B:TCR902 4.6 19.0 1.0
C B:GLY273 4.7 26.6 1.0
N B:PRO274 4.7 26.0 1.0
CH2 B:TCR902 4.8 19.0 1.0
CG B:PRO274 4.9 26.0 1.0
CD1 B:PHE42 4.9 23.1 1.0
N B:SER303 4.9 28.2 1.0
CB B:LEU304 4.9 27.3 1.0
C B:SER302 5.0 26.8 1.0
CZ B:PHE42 5.0 23.1 1.0

Calcium binding site 8 out of 8 in 7sim

Go back to Calcium Binding Sites List in 7sim
Calcium binding site 8 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca907

b:43.6
occ:1.00
 O B:GLY557 2.4 44.5 1.0
C B:GLY557 3.4 44.5 1.0
OD2 A:ASP234 3.5 44.9 1.0
OD1 A:ASP234 3.6 44.9 1.0
CG A:ASP234 3.9 44.9 1.0
CA B:GLY557 4.0 44.5 1.0
O A:GLU231 4.4 44.6 1.0
N B:GLU558 4.4 46.1 1.0
CA B:GLU558 4.7 46.1 1.0

Reference:

J.Park, H.Zuo, A.Frangaj, Z.Fu, L.Y.Yen, Z.Zhang, L.Mosyak, V.N.Slavkovich, J.Liu, K.M.Ray, B.Cao, F.Vallese, Y.Geng, S.Chen, R.Grassucci, V.P.Dandey, Y.Z.Tan, E.Eng, Y.Lee, B.Kloss, Z.Liu, W.A.Hendrickson, C.S.Potter, B.Carragher, J.Graziano, A.D.Conigrave, J.Frank, O.B.Clarke, Q.R.Fan. Symmetric Activation and Modulation of the Human Calcium-Sensing Receptor. Proc.Natl.Acad.Sci.Usa V. 118 2021.
ISSN: ESSN 1091-6490
PubMed: 34916296
DOI: 10.1073/PNAS.2115849118
Page generated: Tue Apr 4 18:41:06 2023

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