Calcium in PDB 7tha: Crystal Structure of Human Transthyretin Variant C10A/M13V

The structure of Crystal Structure of Human Transthyretin Variant C10A/M13V, PDB code: 7tha was solved by M.Jaeger, D.E.Mortenson, N.L.Yan, J.W.Kelly, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.87 / 1.75
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	42.602, 64.509, 85.919, 90, 90, 90
R / Rfree (%)	18.1 / 21.1

The binding sites of Calcium atom in the Crystal Structure of Human Transthyretin Variant C10A/M13V (pdb code 7tha). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of Human Transthyretin Variant C10A/M13V, PDB code: 7tha:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Crystal Structure of Human Transthyretin Variant C10A/M13V


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Transthyretin Variant C10A/M13V within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca201 b:54.4 occ:1.00 O A:HOH318 2.3 43.9 1.0 O A:HOH346 2.7 53.3 1.0 O A:HOH382 3.0 56.6 1.0 O A:HOH312 4.5 47.2 1.0 OE2 A:GLU63 4.6 50.0 1.0 O A:PHE44 4.7 22.1 1.0

Calcium binding site 2 out of 3 in the Crystal Structure of Human Transthyretin Variant C10A/M13V


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Human Transthyretin Variant C10A/M13V within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca201 b:72.9 occ:1.00 O B:HOH314 2.3 41.6 1.0 O B:HOH329 2.5 65.4 1.0 O B:HOH353 4.0 47.2 1.0 OE2 B:GLU63 4.3 65.1 1.0 O B:PHE44 4.5 29.6 1.0 O B:LEU58 4.7 28.8 1.0 O B:HOH332 4.9 47.0 1.0 OE1 B:GLU63 5.0 53.4 1.0

Calcium binding site 3 out of 3 in the Crystal Structure of Human Transthyretin Variant C10A/M13V


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of Human Transthyretin Variant C10A/M13V within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca202 b:90.5 occ:1.00 O B:HOH309 2.6 42.8 1.0 OE1 B:GLU61 2.7 40.6 0.5 OE2 B:GLU61 3.3 37.2 0.5 CD B:GLU61 3.4 39.5 0.5 O B:HOH305 3.4 40.5 1.0 O B:HOH354 3.5 45.8 1.0 O B:ARG103 3.7 44.8 1.0 CB B:PRO11 3.9 33.2 1.0 CD2 B:PHE64 4.2 31.3 1.0 O B:HOH303 4.2 45.0 1.0 O B:HOH349 4.2 38.0 1.0 O B:PHE64 4.4 37.1 1.0 OD1 B:ASP99 4.6 41.9 1.0 CG B:PRO11 4.8 32.3 1.0 CG B:GLU61 4.8 39.1 0.5 C B:ARG103 4.8 47.8 1.0 CE2 B:PHE64 4.8 32.2 1.0 CE1 B:TYR105 5.0 35.6 1.0

M.Jaeger, D.E.Mortenson, N.L.Yan, M.S.Ardejani, J.W.Kelly. Lysine Carbamylation Competes with Urea Unfolding of Human Transthyretin Introducing Kinetic Heterogeneity To Be Published.