Calcium in PDB 8a7d: Partial Dimer Complex of Papp-A and Its Inhibitor STC2
Enzymatic activity of Partial Dimer Complex of Papp-A and Its Inhibitor STC2
All present enzymatic activity of Partial Dimer Complex of Papp-A and Its Inhibitor STC2:
3.4.24.79;
Other elements in 8a7d:
The structure of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
(pdb code 8a7d). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the
Partial Dimer Complex of Papp-A and Its Inhibitor STC2, PDB code: 8a7d:
Jump to Calcium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Calcium binding site 1 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 1 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1709
b:169.0
occ:1.00
|
O
|
C:LYS418
|
2.2
|
115.2
|
1.0
|
|
OD2
|
C:ASP436
|
2.2
|
135.4
|
1.0
|
|
OD1
|
C:ASP421
|
2.3
|
142.4
|
1.0
|
|
OD2
|
C:ASP439
|
2.3
|
141.1
|
1.0
|
|
O
|
C:ASN423
|
2.4
|
146.2
|
1.0
|
|
OD2
|
C:ASP425
|
2.4
|
135.8
|
1.0
|
|
OD1
|
C:ASP436
|
2.6
|
136.2
|
1.0
|
|
CG
|
C:ASP436
|
2.7
|
135.1
|
1.0
|
|
CG
|
C:ASP421
|
3.1
|
140.2
|
1.0
|
|
CG
|
C:ASP439
|
3.4
|
140.1
|
1.0
|
|
OD2
|
C:ASP421
|
3.4
|
139.3
|
1.0
|
|
CG
|
C:ASP425
|
3.4
|
134.6
|
1.0
|
|
C
|
C:LYS418
|
3.5
|
116.1
|
1.0
|
|
C
|
C:ASN423
|
3.6
|
144.9
|
1.0
|
|
CB
|
C:ASP439
|
3.8
|
140.1
|
1.0
|
|
CB
|
C:ASP425
|
3.8
|
135.4
|
1.0
|
|
N
|
C:ASP425
|
4.0
|
135.1
|
1.0
|
|
N
|
C:ASP421
|
4.1
|
137.0
|
1.0
|
|
O
|
C:ASP436
|
4.1
|
137.7
|
1.0
|
|
CB
|
C:ASP436
|
4.1
|
135.1
|
1.0
|
|
N
|
C:GLY420
|
4.2
|
137.0
|
1.0
|
|
CA
|
C:ILE419
|
4.2
|
124.1
|
1.0
|
|
N
|
C:ASN423
|
4.2
|
145.1
|
1.0
|
|
N
|
C:ILE419
|
4.3
|
123.9
|
1.0
|
|
CB
|
C:ASP421
|
4.4
|
138.6
|
1.0
|
|
CA
|
C:ASN423
|
4.4
|
144.1
|
1.0
|
|
OD1
|
C:ASP439
|
4.4
|
141.2
|
1.0
|
|
CA
|
C:LYS418
|
4.4
|
116.1
|
1.0
|
|
OD1
|
C:ASP425
|
4.5
|
133.0
|
1.0
|
|
C
|
C:CYS424
|
4.5
|
140.6
|
1.0
|
|
N
|
C:CYS424
|
4.5
|
141.8
|
1.0
|
|
CA
|
C:ASP425
|
4.6
|
135.4
|
1.0
|
|
CB
|
C:LYS418
|
4.6
|
118.2
|
1.0
|
|
C
|
C:ILE419
|
4.6
|
127.6
|
1.0
|
|
CA
|
C:CYS424
|
4.6
|
142.1
|
1.0
|
|
CA
|
C:ASP421
|
4.7
|
138.2
|
1.0
|
|
ND2
|
C:ASN423
|
4.8
|
143.8
|
1.0
|
|
CB
|
C:ASN423
|
4.8
|
142.8
|
1.0
|
|
N
|
C:GLU422
|
4.8
|
147.9
|
1.0
|
|
C
|
C:ASP421
|
4.9
|
140.9
|
1.0
|
|
C
|
C:ASP436
|
5.0
|
135.4
|
1.0
|
|
CA
|
C:ASP436
|
5.0
|
134.1
|
1.0
|
|
Calcium binding site 2 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 2 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1710
b:94.2
occ:1.00
|
OD1
|
C:ASP598
|
2.3
|
94.7
|
1.0
|
|
OE2
|
C:GLU589
|
2.3
|
109.5
|
1.0
|
|
O
|
C:CYS600
|
2.4
|
80.1
|
1.0
|
|
O
|
C:THR603
|
2.4
|
84.9
|
1.0
|
|
OG1
|
C:THR603
|
2.5
|
80.3
|
1.0
|
|
OE1
|
C:GLU589
|
2.8
|
108.7
|
1.0
|
|
CD
|
C:GLU589
|
2.9
|
108.7
|
1.0
|
|
CG
|
C:ASP598
|
3.1
|
89.2
|
1.0
|
|
OD2
|
C:ASP598
|
3.2
|
89.4
|
1.0
|
|
C
|
C:THR603
|
3.5
|
85.5
|
1.0
|
|
C
|
C:CYS600
|
3.6
|
78.3
|
1.0
|
|
CB
|
C:THR603
|
3.7
|
81.3
|
1.0
|
|
CA
|
C:THR603
|
4.0
|
82.8
|
1.0
|
|
N
|
C:CYS600
|
4.2
|
72.2
|
1.0
|
|
N
|
C:THR603
|
4.2
|
81.0
|
1.0
|
|
CA
|
C:CYS600
|
4.3
|
74.3
|
1.0
|
|
CG
|
C:GLU589
|
4.3
|
108.5
|
1.0
|
|
O
|
C:ASN601
|
4.3
|
89.2
|
1.0
|
|
N
|
C:ASP598
|
4.5
|
85.5
|
1.0
|
|
CB
|
C:CYS600
|
4.5
|
71.3
|
1.0
|
|
CB
|
C:ASP598
|
4.5
|
80.7
|
1.0
|
|
N
|
C:ASN601
|
4.6
|
81.8
|
1.0
|
|
C
|
C:ASN601
|
4.7
|
84.2
|
1.0
|
|
N
|
C:ASN604
|
4.7
|
106.6
|
1.0
|
|
O
|
C:THR596
|
4.7
|
84.7
|
1.0
|
|
O
|
C:SER593
|
4.7
|
90.6
|
1.0
|
|
CA
|
C:ASN601
|
4.7
|
82.2
|
1.0
|
|
C
|
C:ASN604
|
4.8
|
109.9
|
1.0
|
|
O
|
C:ASN604
|
4.8
|
110.9
|
1.0
|
|
CA
|
C:PRO592
|
4.9
|
103.8
|
1.0
|
|
CG2
|
C:THR603
|
4.9
|
80.4
|
1.0
|
|
CA
|
C:ASP598
|
4.9
|
77.4
|
1.0
|
|
N
|
C:SER593
|
5.0
|
91.7
|
1.0
|
|
N
|
C:LEU599
|
5.0
|
71.1
|
1.0
|
|
Calcium binding site 3 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 3 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1711
b:185.8
occ:1.00
|
OD2
|
C:ASP469
|
2.3
|
170.5
|
1.0
|
|
OD1
|
C:ASP458
|
2.4
|
181.4
|
1.0
|
|
CG
|
C:ASP469
|
2.7
|
171.2
|
1.0
|
|
CB
|
C:CYS461
|
3.0
|
178.8
|
1.0
|
|
OD1
|
C:ASP469
|
3.2
|
171.7
|
1.0
|
|
N
|
C:ASP458
|
3.3
|
181.1
|
1.0
|
|
CG
|
C:ASP458
|
3.4
|
182.4
|
1.0
|
|
SG
|
C:CYS461
|
3.5
|
181.1
|
1.0
|
|
CB
|
C:ASP469
|
3.6
|
170.8
|
1.0
|
|
O
|
C:VAL456
|
3.7
|
174.9
|
1.0
|
|
C
|
C:CYS457
|
3.7
|
170.3
|
1.0
|
|
CA
|
C:CYS461
|
4.1
|
178.1
|
1.0
|
|
OD2
|
C:ASP458
|
4.1
|
182.2
|
1.0
|
|
N
|
C:CYS461
|
4.1
|
177.6
|
1.0
|
|
CA
|
C:CYS457
|
4.2
|
170.1
|
1.0
|
|
OD1
|
C:ASN454
|
4.2
|
183.3
|
1.0
|
|
CB
|
C:ASP458
|
4.3
|
182.3
|
1.0
|
|
CA
|
C:ASP458
|
4.3
|
180.9
|
1.0
|
|
SG
|
C:CYS473
|
4.5
|
161.2
|
1.0
|
|
O
|
C:LYS451
|
4.6
|
187.5
|
1.0
|
|
C
|
C:CYS461
|
4.6
|
178.3
|
1.0
|
|
N
|
C:MET459
|
4.7
|
165.5
|
1.0
|
|
O
|
C:CYS457
|
4.7
|
169.7
|
1.0
|
|
C
|
C:VAL456
|
4.7
|
174.8
|
1.0
|
|
OE1
|
C:GLU472
|
4.7
|
169.2
|
1.0
|
|
CA
|
C:ASP469
|
4.8
|
170.8
|
1.0
|
|
CG
|
C:ASN454
|
4.9
|
183.3
|
1.0
|
|
N
|
C:CYS457
|
4.9
|
169.2
|
1.0
|
|
ND2
|
C:ASN454
|
4.9
|
183.4
|
1.0
|
|
C
|
C:ASP458
|
5.0
|
179.5
|
1.0
|
|
Calcium binding site 4 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 4 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1712
b:33.7
occ:1.00
|
OD1
|
C:ASP748
|
2.3
|
56.5
|
1.0
|
|
O
|
C:GLU742
|
2.3
|
54.8
|
1.0
|
|
O
|
C:ASP865
|
2.5
|
41.5
|
1.0
|
|
O
|
C:ARG758
|
2.7
|
51.0
|
1.0
|
|
OD1
|
C:ASP865
|
2.9
|
60.3
|
1.0
|
|
CG
|
C:ASP748
|
3.0
|
57.6
|
1.0
|
|
OD2
|
C:ASP748
|
3.1
|
63.0
|
1.0
|
|
C
|
C:GLU742
|
3.5
|
48.3
|
1.0
|
|
C
|
C:ASP865
|
3.6
|
41.5
|
1.0
|
|
C
|
C:ARG758
|
3.9
|
48.5
|
1.0
|
|
O
|
C:GLU744
|
4.0
|
55.1
|
1.0
|
|
CG
|
C:ASP865
|
4.0
|
55.4
|
1.0
|
|
CA
|
C:ASP865
|
4.2
|
37.0
|
1.0
|
|
CD
|
C:LYS535
|
4.2
|
54.2
|
1.0
|
|
N
|
C:ASP748
|
4.2
|
37.8
|
1.0
|
|
O
|
C:HIS746
|
4.4
|
57.8
|
1.0
|
|
CB
|
C:ARG758
|
4.4
|
44.5
|
1.0
|
|
CA
|
C:ALA743
|
4.4
|
32.9
|
1.0
|
|
N
|
C:ALA743
|
4.4
|
33.7
|
1.0
|
|
CB
|
C:ASP748
|
4.4
|
49.1
|
1.0
|
|
CA
|
C:GLU742
|
4.5
|
46.9
|
1.0
|
|
CA
|
C:ARG758
|
4.6
|
47.3
|
1.0
|
|
N
|
C:ALA866
|
4.7
|
31.9
|
1.0
|
|
CB
|
C:ALA866
|
4.7
|
35.8
|
1.0
|
|
CB
|
C:ASP865
|
4.7
|
39.2
|
1.0
|
|
CA
|
C:PRO747
|
4.8
|
31.0
|
1.0
|
|
N
|
C:THR759
|
4.8
|
42.0
|
1.0
|
|
C
|
C:ALA743
|
4.8
|
35.0
|
1.0
|
|
N
|
C:GLU744
|
4.8
|
44.9
|
1.0
|
|
OD2
|
C:ASP865
|
4.8
|
55.3
|
1.0
|
|
CB
|
C:GLU742
|
4.9
|
50.9
|
1.0
|
|
CA
|
C:ASP748
|
4.9
|
37.3
|
1.0
|
|
CA
|
C:THR759
|
4.9
|
40.2
|
1.0
|
|
C
|
C:PRO747
|
4.9
|
41.7
|
1.0
|
|
OE1
|
C:GLU742
|
5.0
|
65.5
|
1.0
|
|
Calcium binding site 5 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 5 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 5 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1713
b:52.8
occ:1.00
|
OD2
|
C:ASP961
|
2.2
|
55.6
|
1.0
|
|
OE1
|
C:GLU958
|
2.2
|
61.7
|
1.0
|
|
O
|
C:TYR946
|
2.2
|
70.6
|
1.0
|
|
OD1
|
C:ASP949
|
2.3
|
60.5
|
1.0
|
|
O
|
C:ILE951
|
2.4
|
61.4
|
1.0
|
|
OE2
|
C:GLU958
|
2.4
|
71.6
|
1.0
|
|
OE1
|
C:GLN953
|
2.6
|
74.2
|
1.0
|
|
CD
|
C:GLU958
|
2.6
|
62.0
|
1.0
|
|
CG
|
C:ASP949
|
3.3
|
65.6
|
1.0
|
|
C
|
C:TYR946
|
3.4
|
64.1
|
1.0
|
|
CG
|
C:ASP961
|
3.4
|
60.0
|
1.0
|
|
CD
|
C:GLN953
|
3.5
|
74.2
|
1.0
|
|
C
|
C:ILE951
|
3.6
|
56.6
|
1.0
|
|
OD2
|
C:ASP949
|
3.6
|
66.5
|
1.0
|
|
NE2
|
C:GLN953
|
3.9
|
75.5
|
1.0
|
|
CA
|
C:CYS947
|
4.0
|
56.6
|
1.0
|
|
CB
|
C:ASP961
|
4.1
|
55.8
|
1.0
|
|
N
|
C:CYS947
|
4.1
|
52.4
|
1.0
|
|
CG
|
C:GLU958
|
4.1
|
61.3
|
1.0
|
|
N
|
C:GLY948
|
4.2
|
54.4
|
1.0
|
|
N
|
C:GLN953
|
4.2
|
68.1
|
1.0
|
|
N
|
C:ILE951
|
4.3
|
61.1
|
1.0
|
|
N
|
C:TYR946
|
4.3
|
70.6
|
1.0
|
|
N
|
C:ASP949
|
4.3
|
62.3
|
1.0
|
|
OD1
|
C:ASP961
|
4.4
|
61.0
|
1.0
|
|
CA
|
C:ILE951
|
4.5
|
61.3
|
1.0
|
|
CA
|
C:TYR946
|
4.5
|
66.6
|
1.0
|
|
N
|
C:ILE952
|
4.6
|
56.0
|
1.0
|
|
C
|
C:CYS947
|
4.6
|
58.0
|
1.0
|
|
CB
|
C:ASP949
|
4.6
|
60.9
|
1.0
|
|
CA
|
C:ILE952
|
4.6
|
59.0
|
1.0
|
|
CG
|
C:GLN953
|
4.7
|
67.9
|
1.0
|
|
CB
|
C:GLN953
|
4.7
|
67.6
|
1.0
|
|
CB
|
C:GLU958
|
4.8
|
62.5
|
1.0
|
|
SG
|
C:CYS975
|
4.8
|
75.7
|
1.0
|
|
N
|
C:GLY950
|
4.9
|
63.3
|
1.0
|
|
CB
|
C:ILE951
|
4.9
|
58.5
|
1.0
|
|
CA
|
C:ASP949
|
4.9
|
59.5
|
1.0
|
|
C
|
C:ILE952
|
5.0
|
63.1
|
1.0
|
|
Calcium binding site 6 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 6 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 6 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1714
b:31.9
occ:1.00
|
OD2
|
C:ASP969
|
2.3
|
61.1
|
1.0
|
|
OD1
|
C:ASP969
|
2.3
|
60.4
|
1.0
|
|
OD2
|
C:ASP962
|
2.3
|
57.8
|
1.0
|
|
O
|
C:ILE966
|
2.5
|
52.9
|
1.0
|
|
O
|
C:CYS971
|
2.6
|
50.8
|
1.0
|
|
CG
|
C:ASP969
|
2.6
|
60.0
|
1.0
|
|
ND2
|
C:ASN964
|
3.1
|
48.5
|
1.0
|
|
CG
|
C:ASP962
|
3.1
|
55.5
|
1.0
|
|
OD1
|
C:ASP962
|
3.2
|
61.7
|
1.0
|
|
C
|
C:ILE966
|
3.6
|
53.2
|
1.0
|
|
C
|
C:CYS971
|
3.7
|
51.3
|
1.0
|
|
N
|
C:ILE966
|
3.9
|
51.0
|
1.0
|
|
O
|
C:ASN964
|
3.9
|
60.2
|
1.0
|
|
CG
|
C:ASN964
|
3.9
|
49.2
|
1.0
|
|
CB
|
C:ASP969
|
4.1
|
51.3
|
1.0
|
|
CA
|
C:ILE966
|
4.2
|
47.8
|
1.0
|
|
CB
|
C:CYS971
|
4.3
|
45.0
|
1.0
|
|
O
|
C:SER972
|
4.3
|
56.0
|
1.0
|
|
C
|
C:ASN964
|
4.4
|
53.8
|
1.0
|
|
CB
|
C:ASN964
|
4.4
|
46.9
|
1.0
|
|
CA
|
C:CYS971
|
4.4
|
53.0
|
1.0
|
|
N
|
C:CYS971
|
4.6
|
56.4
|
1.0
|
|
CB
|
C:ASP962
|
4.6
|
47.2
|
1.0
|
|
C
|
C:SER972
|
4.6
|
51.4
|
1.0
|
|
CB
|
C:ILE966
|
4.6
|
49.7
|
1.0
|
|
N
|
C:ASN967
|
4.7
|
45.6
|
1.0
|
|
OD1
|
C:ASN964
|
4.8
|
54.6
|
1.0
|
|
N
|
C:SER972
|
4.8
|
53.7
|
1.0
|
|
N
|
C:LYS965
|
4.9
|
56.7
|
1.0
|
|
C
|
C:LYS965
|
4.9
|
47.5
|
1.0
|
|
CA
|
C:ASN967
|
4.9
|
44.2
|
1.0
|
|
N
|
C:ASP969
|
4.9
|
55.1
|
1.0
|
|
CA
|
C:ASP969
|
5.0
|
43.0
|
1.0
|
|
CA
|
C:ASN964
|
5.0
|
42.7
|
1.0
|
|
Calcium binding site 7 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 7 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 7 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Ca1715
b:120.4
occ:1.00
|
OE1
|
C:GLU1003
|
2.3
|
134.5
|
1.0
|
|
OD1
|
C:ASP996
|
2.4
|
93.9
|
1.0
|
|
O
|
C:HIS993
|
2.4
|
83.7
|
1.0
|
|
OE1
|
C:GLU1000
|
2.5
|
135.3
|
1.0
|
|
O
|
C:VAL998
|
2.5
|
121.7
|
1.0
|
|
CD
|
C:GLU1003
|
2.7
|
131.3
|
1.0
|
|
OD2
|
C:ASP1010
|
2.7
|
120.6
|
1.0
|
|
OE2
|
C:GLU1003
|
2.9
|
129.1
|
1.0
|
|
CD
|
C:GLU1000
|
3.1
|
133.4
|
1.0
|
|
OE2
|
C:GLU1000
|
3.1
|
130.3
|
1.0
|
|
CG
|
C:ASP996
|
3.4
|
91.1
|
1.0
|
|
C
|
C:HIS993
|
3.4
|
77.8
|
1.0
|
|
CG
|
C:ASP1010
|
3.7
|
122.5
|
1.0
|
|
C
|
C:VAL998
|
3.7
|
121.0
|
1.0
|
|
CB
|
C:HIS993
|
3.8
|
77.2
|
1.0
|
|
CG
|
C:GLU1003
|
3.9
|
130.0
|
1.0
|
|
OD2
|
C:ASP996
|
3.9
|
91.9
|
1.0
|
|
CA
|
C:HIS993
|
3.9
|
75.1
|
1.0
|
|
CB
|
C:ASP1010
|
4.2
|
126.5
|
1.0
|
|
N
|
C:ASP996
|
4.4
|
95.3
|
1.0
|
|
CA
|
C:CYS999
|
4.4
|
139.8
|
1.0
|
|
N
|
C:GLY995
|
4.4
|
92.2
|
1.0
|
|
CB
|
C:ASP996
|
4.5
|
88.7
|
1.0
|
|
CG
|
C:GLU1000
|
4.5
|
131.7
|
1.0
|
|
N
|
C:CYS999
|
4.5
|
138.5
|
1.0
|
|
N
|
C:ASP994
|
4.6
|
81.6
|
1.0
|
|
N
|
C:VAL998
|
4.7
|
123.2
|
1.0
|
|
CB
|
C:GLU1003
|
4.7
|
131.8
|
1.0
|
|
OD1
|
C:ASP1010
|
4.7
|
120.9
|
1.0
|
|
CG
|
C:HIS993
|
4.7
|
76.4
|
1.0
|
|
N
|
C:GLU1000
|
4.7
|
133.8
|
1.0
|
|
CA
|
C:VAL998
|
4.7
|
121.5
|
1.0
|
|
CD2
|
C:HIS993
|
4.8
|
81.1
|
1.0
|
|
C
|
C:CYS999
|
4.8
|
140.6
|
1.0
|
|
CA
|
C:ASP994
|
4.9
|
87.4
|
1.0
|
|
CA
|
C:ASP996
|
4.9
|
92.7
|
1.0
|
|
Calcium binding site 8 out
of 8 in 8a7d
Go back to
Calcium Binding Sites List in 8a7d
Calcium binding site 8 out
of 8 in the Partial Dimer Complex of Papp-A and Its Inhibitor STC2
 Mono view
 Stereo pair view
|
|
A full contact list of Calcium with other atoms in the Ca binding
site number 8 of Partial Dimer Complex of Papp-A and Its Inhibitor STC2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
Q:Ca1702
b:166.1
occ:1.00
|
OD1
|
Q:ASP1568
|
2.2
|
152.9
|
1.0
|
|
O
|
Q:PHE1561
|
2.2
|
149.4
|
1.0
|
|
O
|
Q:TYR1566
|
2.3
|
137.6
|
1.0
|
|
OD1
|
Q:ASP1579
|
2.3
|
162.0
|
1.0
|
|
OD2
|
Q:ASP1579
|
2.4
|
160.3
|
1.0
|
|
CG
|
Q:ASP1579
|
2.7
|
160.3
|
1.0
|
|
OD2
|
Q:ASP1582
|
2.7
|
153.2
|
1.0
|
|
OD1
|
Q:ASP1564
|
2.8
|
146.6
|
1.0
|
|
C
|
Q:PHE1561
|
3.2
|
148.8
|
1.0
|
|
CG
|
Q:ASP1568
|
3.4
|
152.5
|
1.0
|
|
C
|
Q:TYR1566
|
3.5
|
136.3
|
1.0
|
|
CB
|
Q:PHE1561
|
3.6
|
148.8
|
1.0
|
|
CG
|
Q:ASP1564
|
3.8
|
145.9
|
1.0
|
|
CG
|
Q:ASP1582
|
3.8
|
153.4
|
1.0
|
|
OD2
|
Q:ASP1568
|
3.9
|
155.4
|
1.0
|
|
N
|
Q:MET1562
|
4.0
|
150.9
|
1.0
|
|
CA
|
Q:PHE1561
|
4.1
|
149.4
|
1.0
|
|
N
|
Q:ASP1568
|
4.1
|
150.4
|
1.0
|
|
OD2
|
Q:ASP1564
|
4.1
|
146.4
|
1.0
|
|
CA
|
Q:MET1562
|
4.2
|
152.3
|
1.0
|
|
CB
|
Q:ASP1579
|
4.2
|
159.3
|
1.0
|
|
O
|
Q:ASP1579
|
4.2
|
160.7
|
1.0
|
|
CB
|
Q:ASP1582
|
4.2
|
152.5
|
1.0
|
|
CA
|
Q:TYR1566
|
4.3
|
136.2
|
1.0
|
|
N
|
Q:TYR1566
|
4.4
|
136.3
|
1.0
|
|
CB
|
Q:TYR1566
|
4.4
|
136.1
|
1.0
|
|
N
|
Q:GLY1563
|
4.4
|
151.0
|
1.0
|
|
N
|
Q:CYS1567
|
4.4
|
144.0
|
1.0
|
|
CB
|
Q:ASP1568
|
4.5
|
150.9
|
1.0
|
|
N
|
Q:ASP1564
|
4.6
|
146.1
|
1.0
|
|
C
|
Q:MET1562
|
4.6
|
151.7
|
1.0
|
|
CA
|
Q:CYS1567
|
4.6
|
145.3
|
1.0
|
|
C
|
Q:CYS1567
|
4.8
|
145.8
|
1.0
|
|
ND2
|
Q:ASN1571
|
4.9
|
155.9
|
1.0
|
|
OD1
|
Q:ASP1582
|
4.9
|
153.5
|
1.0
|
|
CA
|
Q:ASP1568
|
4.9
|
151.0
|
1.0
|
|
CA
|
Q:ASP1579
|
4.9
|
160.4
|
1.0
|
|
CB
|
Q:ASP1564
|
5.0
|
144.5
|
1.0
|
|
C
|
Q:ASP1579
|
5.0
|
160.6
|
1.0
|
|
Reference:
S.D.Kobbero,
M.Gajhede,
O.A.Mirza,
S.Kloverpris,
T.R.Kjaer,
J.H.Mikkelsen,
T.Boesen,
C.Oxvig.
Structure of the Proteolytic Enzyme Papp-A with the Endogenous Inhibitor Stanniocalcin-2 Reveals Its Inhibitory Mechanism. Nat Commun V. 13 6084 2022.
ISSN: ESSN 2041-1723
PubMed: 36257932
DOI: 10.1038/S41467-022-33698-8
Page generated: Fri Jul 19 06:48:03 2024
|
