Calcium in PDB 8e6s: Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+

Other elements in 8e6s:

The structure of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ also contains other interesting chemical elements:

Zinc (Zn) 4 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ (pdb code 8e6s). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+, PDB code: 8e6s:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in 8e6s

Go back to Calcium Binding Sites List in 8e6s
Calcium binding site 1 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1604

b:280.9
occ:1.00
 N A:TRP868 2.7 250.0 1.0
CD1 A:TRP868 2.8 250.0 1.0
CB A:ASP866 3.0 269.6 1.0
N A:PHE867 3.0 274.0 1.0
CB A:TRP868 3.2 250.0 1.0
CG A:TRP868 3.3 250.0 1.0
C A:ASP866 3.4 269.6 1.0
NZ A:LYS932 3.5 234.8 1.0
CA A:TRP868 3.5 250.0 1.0
CG A:ASP866 3.6 269.6 1.0
CA A:ASP866 3.6 269.6 1.0
C A:PHE867 3.6 274.0 1.0
CA A:PHE867 3.7 274.0 1.0
NE1 A:TRP868 4.0 250.0 1.0
CE A:LYS932 4.0 234.8 1.0
OD1 A:ASP866 4.1 269.6 1.0
OD2 A:ASP866 4.1 269.6 1.0
O A:ASP866 4.1 269.6 1.0
CB A:PHE867 4.2 274.0 1.0
N A:ASN869 4.3 271.0 1.0
C A:TRP868 4.4 250.0 1.0
CD2 A:TRP868 4.6 250.0 1.0
CD A:LYS932 4.7 234.8 1.0
O A:PHE867 4.8 274.0 1.0
OD1 A:ASN869 4.9 271.0 1.0
CE2 A:TRP868 4.9 250.0 1.0
N A:ASP866 5.0 269.6 1.0

Calcium binding site 2 out of 4 in 8e6s

Go back to Calcium Binding Sites List in 8e6s
Calcium binding site 2 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1604

b:263.1
occ:1.00
 N B:TRP868 2.7 236.5 1.0
CD1 B:TRP868 2.8 236.5 1.0
CB B:ASP866 3.0 262.9 1.0
N B:PHE867 3.0 265.1 1.0
CB B:TRP868 3.2 236.5 1.0
CG B:TRP868 3.3 236.5 1.0
C B:ASP866 3.4 262.9 1.0
NZ B:LYS932 3.5 237.6 1.0
CA B:TRP868 3.5 236.5 1.0
CG B:ASP866 3.6 262.9 1.0
CA B:ASP866 3.6 262.9 1.0
C B:PHE867 3.6 265.1 1.0
CA B:PHE867 3.7 265.1 1.0
NE1 B:TRP868 4.0 236.5 1.0
CE B:LYS932 4.0 237.6 1.0
OD1 B:ASP866 4.1 262.9 1.0
OD2 B:ASP866 4.1 262.9 1.0
O B:ASP866 4.1 262.9 1.0
CB B:PHE867 4.2 265.1 1.0
N B:ASN869 4.3 259.1 1.0
C B:TRP868 4.4 236.5 1.0
CD2 B:TRP868 4.6 236.5 1.0
CD B:LYS932 4.7 237.6 1.0
O B:PHE867 4.8 265.1 1.0
OD1 B:ASN869 4.9 259.1 1.0
CE2 B:TRP868 4.9 236.5 1.0
N B:ASP866 5.0 262.9 1.0

Calcium binding site 3 out of 4 in 8e6s

Go back to Calcium Binding Sites List in 8e6s
Calcium binding site 3 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ca1604

b:320.0
occ:1.00
 N C:TRP868 2.7 271.5 1.0
CD1 C:TRP868 2.8 271.5 1.0
CB C:ASP866 3.0 291.1 1.0
N C:PHE867 3.0 286.9 1.0
CB C:TRP868 3.2 271.5 1.0
CG C:TRP868 3.3 271.5 1.0
C C:ASP866 3.4 291.1 1.0
NZ C:LYS932 3.5 244.8 1.0
CA C:TRP868 3.5 271.5 1.0
CG C:ASP866 3.6 291.1 1.0
CA C:ASP866 3.6 291.1 1.0
C C:PHE867 3.6 286.9 1.0
CA C:PHE867 3.7 286.9 1.0
NE1 C:TRP868 4.0 271.5 1.0
CE C:LYS932 4.0 244.8 1.0
OD1 C:ASP866 4.1 291.1 1.0
OD2 C:ASP866 4.1 291.1 1.0
O C:ASP866 4.1 291.1 1.0
CB C:PHE867 4.2 286.9 1.0
N C:ASN869 4.3 284.8 1.0
C C:TRP868 4.4 271.5 1.0
CD2 C:TRP868 4.6 271.5 1.0
CD C:LYS932 4.7 244.8 1.0
O C:PHE867 4.8 286.9 1.0
OD1 C:ASN869 4.9 284.8 1.0
CE2 C:TRP868 4.9 271.5 1.0
N C:ASP866 5.0 291.1 1.0

Calcium binding site 4 out of 4 in 8e6s

Go back to Calcium Binding Sites List in 8e6s
Calcium binding site 4 out of 4 in the Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human TRPM2 Ion Channel in 1 Mm Dadpr and CA2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Ca1604

b:301.0
occ:1.00
 N D:TRP868 2.7 253.9 1.0
CD1 D:TRP868 2.8 253.9 1.0
CB D:ASP866 3.0 274.6 1.0
N D:PHE867 3.0 277.7 1.0
CB D:TRP868 3.2 253.9 1.0
CG D:TRP868 3.3 253.9 1.0
C D:ASP866 3.4 274.6 1.0
NZ D:LYS932 3.5 233.4 1.0
CA D:TRP868 3.5 253.9 1.0
CG D:ASP866 3.6 274.6 1.0
CA D:ASP866 3.6 274.6 1.0
C D:PHE867 3.6 277.7 1.0
CA D:PHE867 3.7 277.7 1.0
NE1 D:TRP868 4.0 253.9 1.0
CE D:LYS932 4.0 233.4 1.0
OD1 D:ASP866 4.1 274.6 1.0
OD2 D:ASP866 4.1 274.6 1.0
O D:ASP866 4.1 274.6 1.0
CB D:PHE867 4.2 277.7 1.0
N D:ASN869 4.3 279.8 1.0
C D:TRP868 4.4 253.9 1.0
CD2 D:TRP868 4.6 253.9 1.0
CD D:LYS932 4.7 233.4 1.0
O D:PHE867 4.8 277.7 1.0
OD1 D:ASN869 4.9 279.8 1.0
CE2 D:TRP868 4.9 253.9 1.0
N D:ASP866 5.0 274.6 1.0

Reference:

L.Wang, T.-M.Fu. A Unified Mechanism For Human TRPM2 Activation, Desensitization and Inhibition To Be Published.
Page generated: Sat Sep 28 09:00:11 2024

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