Atomistry » Calcium » PDB 8fyo-8gsw » 8gm5
Atomistry »
  Calcium »
    PDB 8fyo-8gsw »
      8gm5 »

Calcium in PDB 8gm5: Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop

Enzymatic activity of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop

All present enzymatic activity of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop:
2.7.11.20;

Protein crystallography data

The structure of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop, PDB code: 8gm5 was solved by A.Piserchio, E.A.Isiorho, K.N.Dalby, R.Ghose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.94 / 2.12
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 80.909, 61.041, 88.958, 90, 111.26, 90
R / Rfree (%) 18.1 / 22.5

Other elements in 8gm5:

The structure of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop (pdb code 8gm5). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop, PDB code: 8gm5:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 8gm5

Go back to Calcium Binding Sites List in 8gm5
Calcium binding site 1 out of 2 in the Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca201

b:26.7
occ:1.00
 OD1 B:ASP95 2.3 38.9 1.0
OD1 B:ASP93 2.3 27.8 1.0
O B:TYR99 2.3 31.9 1.0
OE2 B:GLU104 2.3 32.3 1.0
OD1 B:ASN97 2.4 24.8 1.0
OE1 B:GLU104 2.4 34.7 1.0
O A:HOH1007 2.5 32.2 1.0
CD B:GLU104 2.7 29.7 1.0
CG B:ASP95 3.2 35.8 1.0
CG B:ASN97 3.4 28.5 1.0
CG B:ASP93 3.5 26.0 1.0
C B:TYR99 3.5 24.2 1.0
OD2 B:ASP95 3.8 30.3 1.0
N B:TYR99 4.1 30.3 1.0
CG B:GLU104 4.2 25.4 1.0
ND2 B:ASN97 4.2 23.5 1.0
N B:ASN97 4.2 24.6 1.0
N B:ASP95 4.2 25.6 1.0
OD2 B:ASP93 4.3 30.5 1.0
CB B:ASP95 4.3 22.0 1.0
CA B:TYR99 4.3 27.2 1.0
CA B:ASP93 4.3 30.8 1.0
CB B:ASN97 4.4 29.9 1.0
CB B:ASP93 4.5 30.5 1.0
N B:ILE100 4.5 24.8 1.0
N B:GLY96 4.5 27.2 1.0
C B:ASP93 4.5 29.1 1.0
N B:LYS94 4.6 25.4 1.0
CA B:ILE100 4.6 21.7 1.0
CA B:ASP95 4.7 23.0 1.0
OD1 A:ASP208 4.7 46.1 1.0
CA B:ASN97 4.7 23.6 1.0
N B:SER101 4.7 31.9 1.0
CB B:TYR99 4.8 27.3 1.0
N B:GLY98 4.8 32.2 1.0
NZ A:LYS192 4.8 26.4 1.0
C B:ASP95 4.8 29.7 1.0
C B:ASN97 5.0 34.3 1.0

Calcium binding site 2 out of 2 in 8gm5

Go back to Calcium Binding Sites List in 8gm5
Calcium binding site 2 out of 2 in the Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca202

b:39.3
occ:1.00
 OD1 B:ASP131 2.2 54.4 1.0
O B:GLN135 2.2 41.7 1.0
OD1 B:ASP133 2.4 50.5 1.0
OD1 B:ASP129 2.4 40.2 1.0
OE1 B:GLU140 2.5 33.4 1.0
OE2 B:GLU140 2.6 36.0 1.0
CD B:GLU140 2.9 35.2 1.0
CG B:ASP133 3.1 50.5 1.0
CG B:ASP131 3.1 61.0 1.0
OD2 B:ASP133 3.3 41.9 1.0
C B:GLN135 3.4 32.0 1.0
OD2 B:ASP131 3.4 70.6 1.0
CG B:ASP129 3.6 40.7 1.0
N B:ASN137 4.2 29.5 1.0
N B:VAL136 4.2 30.6 1.0
CA B:VAL136 4.3 33.1 1.0
N B:GLN135 4.3 38.8 1.0
CA B:GLN135 4.4 33.9 1.0
CA B:ASP129 4.4 44.8 1.0
CB B:ASP133 4.4 46.5 1.0
CG B:GLU140 4.4 23.0 1.0
OD2 B:ASP129 4.4 46.1 1.0
N B:ASP133 4.5 44.2 1.0
CB B:ASP131 4.5 53.1 1.0
CB B:ASP129 4.5 34.5 1.0
N B:ASP131 4.6 39.9 1.0
O B:HOH307 4.6 45.9 1.0
C B:VAL136 4.7 28.8 1.0
CG B:ASN137 4.7 30.6 1.0
ND2 B:ASN137 4.7 29.3 1.0
N B:GLY132 4.8 40.4 1.0
N B:ILE130 4.8 44.1 1.0
C B:ASP129 4.9 51.4 1.0
CA B:ASP133 4.9 37.5 1.0
CB B:GLN135 4.9 40.4 1.0
CB B:ASN137 4.9 26.0 1.0
CA B:ASP131 5.0 40.7 1.0

Reference:

A.Piserchio, E.A.Isiorho, K.N.Dalby, R.Ghose. Structure of the Complex Between Calmodulin and A Functional Construct of Eukaryotic Elongation Factor 2 Kinase Bound to An Atp-Competitive Inhibitor. J.Biol.Chem. 04813 2023.
ISSN: ESSN 1083-351X
PubMed: 37172726
DOI: 10.1016/J.JBC.2023.104813
Page generated: Fri Jul 19 09:13:58 2024

Last articles

Mg in 4Y52
Mg in 4Y30
Mg in 4Y2V
Mg in 4Y2X
Mg in 4Y2Y
Mg in 4Y2U
Mg in 4Y2T
Mg in 4Y2Q
Mg in 4Y2R
Mg in 4Y2S
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy