Calcium in PDB 8qzc: Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution

The binding sites of Calcium atom in the Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution (pdb code 8qzc). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution, PDB code: 8qzc:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1001 b:17.6 occ:1.00 OE2 A:GLU705 2.5 21.5 1.0 OD1 A:ASP738 2.5 27.2 1.0 OD2 A:ASP738 2.9 27.2 1.0 CG A:ASP738 3.0 27.2 1.0 CD A:GLU705 3.7 21.5 1.0 OH A:TYR331 4.0 23.3 1.0 NZ A:LYS741 4.1 33.3 1.0 CG A:GLU702 4.3 25.4 1.0 CE A:MET706 4.3 20.5 1.0 OE1 A:GLU705 4.4 21.5 1.0 CB A:ASP738 4.5 27.2 1.0 CB A:GLU702 4.6 25.4 1.0 CG A:GLU705 4.7 21.5 1.0 CD A:GLU702 4.8 25.4 1.0 CA A:GLU702 4.8 25.4 1.0 CE A:LYS741 4.9 33.3 1.0 O A:GLU734 4.9 30.3 1.0

Calcium binding site 2 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:48.2 occ:1.00 O A:ASP883 2.5 26.9 1.0 OD1 A:ASP888 2.5 46.6 1.0 OD2 A:ASP883 2.7 26.9 1.0 O A:ILE886 2.8 31.4 1.0 CG A:ASP888 3.4 46.6 1.0 C A:ASP883 3.5 26.9 1.0 CG A:ASP883 3.9 26.9 1.0 OD2 A:ASP888 3.9 46.6 1.0 N A:ASP888 4.0 46.6 1.0 C A:ILE886 4.0 31.4 1.0 C A:PRO887 4.2 39.6 1.0 CA A:ASP883 4.3 26.9 1.0 OE2 A:GLU425 4.3 29.8 1.0 CA A:PRO887 4.4 39.6 1.0 CA A:ASP888 4.5 46.6 1.0 N A:TRP884 4.5 29.2 1.0 CB A:ASP888 4.6 46.6 1.0 CB A:ASP883 4.7 26.9 1.0 N A:PRO887 4.7 39.6 1.0 CA A:TRP884 4.7 29.2 1.0 OD1 A:ASP883 4.8 26.9 1.0 O A:PRO887 4.8 39.6 1.0 NZ A:LYS428 4.9 32.6 1.0 O A:TRP884 4.9 29.2 1.0 CD A:GLU425 4.9 29.8 1.0 C A:TRP884 4.9 29.2 1.0

Calcium binding site 3 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1001 b:18.0 occ:1.00 OD1 B:ASP738 2.5 26.5 1.0 OE2 B:GLU705 2.5 21.8 1.0 OD2 B:ASP738 2.9 26.5 1.0 CG B:ASP738 3.0 26.5 1.0 CD B:GLU705 3.7 21.8 1.0 OH B:TYR331 4.0 23.0 1.0 NZ B:LYS741 4.1 33.0 1.0 CG B:GLU702 4.3 25.3 1.0 CE B:MET706 4.3 20.5 1.0 OE1 B:GLU705 4.4 21.8 1.0 CB B:ASP738 4.5 26.5 1.0 CB B:GLU702 4.6 25.3 1.0 CG B:GLU705 4.7 21.8 1.0 CD B:GLU702 4.8 25.3 1.0 CA B:GLU702 4.8 25.3 1.0 CE B:LYS741 4.9 33.0 1.0 O B:GLU734 4.9 29.4 1.0 CD2 B:LEU737 5.0 31.7 1.0

Calcium binding site 4 out of 4 in the Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Calcium-Bound MTMEM16A(Ac)-L647V/I733V Chloride Channel at 3.29 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1002 b:51.2 occ:1.00 O B:ASP883 2.5 28.5 1.0 OD1 B:ASP888 2.5 47.6 1.0 OD1 B:ASP883 2.7 28.5 1.0 O B:ILE886 2.8 32.5 1.0 CG B:ASP888 3.5 47.6 1.0 C B:ASP883 3.5 28.5 1.0 CG B:ASP883 3.9 28.5 1.0 OD2 B:ASP888 3.9 47.6 1.0 C B:ILE886 4.1 32.5 1.0 N B:ASP888 4.1 47.6 1.0 CG B:GLU425 4.1 31.6 1.0 CA B:ASP883 4.2 28.5 1.0 C B:PRO887 4.3 40.9 1.0 CA B:PRO887 4.5 40.9 1.0 N B:TRP884 4.6 31.1 1.0 CA B:ASP888 4.6 47.6 1.0 CB B:ASP888 4.6 47.6 1.0 CB B:ASP883 4.7 28.5 1.0 OE2 B:GLU425 4.7 31.6 1.0 NZ B:LYS428 4.8 33.5 1.0 CA B:TRP884 4.8 31.1 1.0 N B:PRO887 4.8 40.9 1.0 CD B:GLU425 4.8 31.6 1.0 OD2 B:ASP883 4.9 28.5 1.0 O B:PRO887 4.9 40.9 1.0 O B:TRP884 5.0 31.1 1.0

A.K.Lam, R.Dutzler. Mechanistic Basis of Ligand Efficacy in the Calcium-Activated Chloride Channel TMEM16A. Embo J. 15030 2023.
ISSN: ESSN 1460-2075
PubMed: 37984335
DOI: 10.15252/EMBJ.2023115030