Calcium in PDB 8sia: Cryo-Em Structure of TRPM7 N1098Q Mutant in Gdn Detergent in Complex with Inhibitor NS8593 in Closed State

All present enzymatic activity of Cryo-Em Structure of TRPM7 N1098Q Mutant in Gdn Detergent in Complex with Inhibitor NS8593 in Closed State:
2.7.11.1;

The binding sites of Calcium atom in the Cryo-Em Structure of TRPM7 N1098Q Mutant in Gdn Detergent in Complex with Inhibitor NS8593 in Closed State (pdb code 8sia). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Cryo-Em Structure of TRPM7 N1098Q Mutant in Gdn Detergent in Complex with Inhibitor NS8593 in Closed State, PDB code: 8sia:

Calcium binding site 1 out of 1 in the Cryo-Em Structure of TRPM7 N1098Q Mutant in Gdn Detergent in Complex with Inhibitor NS8593 in Closed State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of TRPM7 N1098Q Mutant in Gdn Detergent in Complex with Inhibitor NS8593 in Closed State within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1319 b:21.6 occ:1.00 HA2 A:GLY1046 2.9 24.5 1.0 HA2 B:GLY1046 3.0 24.6 1.0 HA2 D:GLY1046 3.0 25.8 1.0 HA3 A:GLY1046 3.1 24.5 1.0 HA2 C:GLY1046 3.2 25.2 1.0 HA3 B:GLY1046 3.2 24.6 1.0 HA3 D:GLY1046 3.2 25.8 1.0 HA3 C:GLY1046 3.4 25.2 1.0 CA A:GLY1046 3.5 24.5 1.0 CA B:GLY1046 3.5 24.6 1.0 CA D:GLY1046 3.5 25.8 1.0 CA C:GLY1046 3.7 25.2 1.0 N A:GLY1046 4.4 24.5 1.0 N B:GLY1046 4.4 24.6 1.0 N D:GLY1046 4.4 25.8 1.0 O A:GLY1046 4.5 24.5 1.0 C A:GLY1046 4.5 24.5 1.0 O D:GLY1046 4.6 25.8 1.0 O B:GLY1046 4.6 24.6 1.0 C D:GLY1046 4.6 25.8 1.0 C B:GLY1046 4.6 24.6 1.0 N C:GLY1046 4.6 25.2 1.0 H A:GLY1046 4.7 24.5 1.0 H B:GLY1046 4.7 24.6 1.0 O C:GLY1046 4.7 25.2 1.0 H D:GLY1046 4.7 25.8 1.0 C C:GLY1046 4.7 25.2 1.0 H C:GLY1046 4.9 25.2 1.0

K.D.Nadezhdin, L.Correia, C.Narangoda, D.S.Patel, A.Neuberger, T.Gudermann, M.G.Kurnikova, V.Chubanov, A.I.Sobolevsky. Structural Mechanisms of TRPM7 Activation and Inhibition Nat Commun 2023.
ISSN: ESSN 2041-1723
PubMed: 37156763