Calcium in PDB 8szf: Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs

The structure of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs (pdb code 8szf). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs, PDB code: 8szf:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1204 b:46.1 occ:1.00 O A:LEU87 2.4 23.3 1.0 O A:LEU88 2.7 28.6 1.0 O A:SER84 2.9 24.2 1.0 O A:ILE81 3.3 16.6 1.0 C A:LEU88 3.5 25.0 1.0 C A:LEU87 3.6 24.6 1.0 CB A:LEU88 4.1 18.5 1.0 O A:ASN82 4.1 11.1 1.0 O A:LEU91 4.1 29.0 1.0 CA A:LEU88 4.1 19.5 1.0 C A:SER84 4.2 22.3 1.0 N A:PRO89 4.2 27.8 1.0 N A:LEU88 4.3 24.0 1.0 C A:ILE81 4.4 9.6 1.0 CA A:ASN82 4.4 6.4 1.0 CA A:PRO89 4.4 24.7 1.0 C A:ASN82 4.5 7.0 1.0 CA A:LEU87 4.7 20.1 1.0 N A:LEU87 4.8 26.8 1.0 CA A:PRO85 4.9 26.7 1.0 N A:ASN82 4.9 10.0 1.0 CG2 A:ILE81 5.0 7.1 1.0 N A:SER84 5.0 22.1 1.0

Calcium binding site 2 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1205 b:66.5 occ:1.00 O A:GLY557 2.6 50.8 1.0 C A:GLY557 3.7 44.4 1.0 OE1 A:GLU558 4.0 47.4 1.0 CA A:GLU558 4.1 36.9 1.0 OE2 A:GLU558 4.2 47.5 1.0 CD A:PRO559 4.2 36.9 1.0 CD A:GLU558 4.3 48.1 1.0 N A:GLU558 4.3 41.0 1.0 C A:GLU558 4.7 41.6 1.0 CA A:GLY557 4.8 40.4 1.0 N A:PRO559 4.8 37.3 1.0 OD1 B:ASP234 4.9 36.7 1.0

Calcium binding site 3 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1206 b:65.8 occ:1.00 OD1 A:ASP234 2.5 40.1 1.0 O B:GLY557 3.1 46.8 1.0 CG A:ASP234 3.3 37.3 1.0 OD2 A:ASP234 3.5 38.9 1.0 C B:GLY557 3.9 46.1 1.0 CA B:GLY557 4.1 44.0 1.0 O A:GLU231 4.4 32.0 1.0 O A:GLU232 4.7 29.3 1.0 CB A:ASP234 4.7 29.4 1.0

Calcium binding site 4 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1004 b:55.0 occ:1.00 O B:SER84 2.5 29.6 1.0 O B:LEU88 3.0 36.1 1.0 O B:ILE81 3.3 13.1 1.0 O B:ASN82 3.4 19.6 1.0 C B:SER84 3.6 27.2 1.0 C B:LEU88 3.6 35.0 1.0 C B:ASN82 3.9 14.8 1.0 N B:LEU88 4.0 28.3 1.0 CA B:PRO85 4.2 31.6 1.0 CA B:ASN82 4.2 14.3 1.0 CA B:LEU88 4.3 32.0 1.0 N B:PRO85 4.3 36.0 1.0 N B:PRO89 4.4 36.9 1.0 O B:LEU91 4.4 36.6 1.0 C B:ILE81 4.4 12.4 1.0 N B:SER84 4.4 28.9 1.0 CB B:LEU88 4.5 33.8 1.0 CA B:PRO89 4.6 34.7 1.0 CA B:SER84 4.6 24.7 1.0 C B:SER83 4.7 22.4 1.0 C B:PRO85 4.7 33.4 1.0 N B:SER83 4.8 21.3 1.0 N B:ASN82 4.8 19.7 1.0 O B:SER83 4.9 20.8 1.0

F.He, C.Wu, Y.Gao, G.Skiniotis. Allosteric Modulation and G-Protein Selectivity of the CA2+-Sensing Receptor Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07055-2