Calcium in PDB 8szg: Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs

The structure of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs (pdb code 8szg). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs, PDB code: 8szg:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1206 b:41.1 occ:1.00 O A:LEU88 2.8 20.4 1.0 O A:SER84 3.2 20.5 1.0 O A:LEU87 3.2 21.7 1.0 O A:ILE81 3.4 15.3 1.0 C A:LEU88 3.6 20.4 1.0 O A:ASN82 3.7 13.8 1.0 O A:LEU91 3.9 21.2 1.0 CA A:PRO89 4.0 22.6 1.0 C A:ASN82 4.1 13.8 1.0 N A:PRO89 4.1 22.6 1.0 CA A:ASN82 4.1 13.8 1.0 C A:SER84 4.2 20.5 1.0 C A:LEU87 4.3 21.7 1.0 C A:ILE81 4.4 15.3 1.0 CA A:LEU88 4.6 20.4 1.0 N A:SER84 4.7 20.5 1.0 C A:PRO89 4.7 22.6 1.0 CA A:PRO85 4.7 23.7 1.0 N A:ASN90 4.8 25.1 1.0 CB A:LEU88 4.8 20.4 1.0 N A:ASN82 4.8 13.8 1.0 N A:PRO85 4.9 23.7 1.0 N A:SER83 4.9 14.7 1.0 N A:LEU88 4.9 20.4 1.0

Calcium binding site 2 out of 3 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1207 b:46.7 occ:1.00 O B:GLY557 2.7 61.5 1.0 OD1 A:ASP234 2.8 25.8 1.0 C B:GLY557 3.7 61.5 1.0 CG A:ASP234 3.8 25.8 1.0 OD2 A:ASP234 4.0 25.8 1.0 CA B:GLY557 4.1 61.5 1.0 O A:GLU232 4.5 29.8 1.0 O A:GLU231 4.5 25.9 1.0 N B:GLU558 4.8 60.1 1.0

Calcium binding site 3 out of 3 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1211 b:45.8 occ:1.00 O A:GLY557 2.9 51.4 1.0 OD1 B:ASP234 3.8 32.4 1.0 C A:GLY557 3.9 51.4 1.0 C9 A:SPM1210 4.0 39.1 1.0 N10 A:SPM1210 4.4 39.1 1.0 CA A:GLU558 4.6 50.3 1.0 N A:GLU558 4.6 50.3 1.0 O B:GLU231 4.6 34.0 1.0 CA A:GLY557 4.7 51.4 1.0 CD A:PRO559 4.8 47.9 1.0 CG B:ASP234 4.9 32.4 1.0

F.He, C.Wu, Y.Gao, G.Skiniotis. Allosteric Modulation and G-Protein Selectivity of the CA2+-Sensing Receptor Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07055-2