Calcium in PDB 8szh: Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs

The structure of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs (pdb code 8szh). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs, PDB code: 8szh:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca904 b:56.7 occ:1.00 O A:LEU88 2.6 35.0 1.0 O A:LEU87 2.8 36.0 1.0 O A:SER84 3.0 39.0 1.0 O A:ILE81 3.2 33.9 1.0 C A:LEU88 3.5 31.0 1.0 O A:ASN82 3.9 29.0 1.0 C A:LEU87 3.9 33.1 1.0 C A:SER84 4.0 38.0 1.0 CA A:PRO89 4.1 39.8 1.0 C A:ASN82 4.1 22.0 1.0 N A:PRO89 4.2 40.1 1.0 CA A:ASN82 4.2 18.1 1.0 C A:ILE81 4.2 28.0 1.0 O A:LEU91 4.3 44.1 1.0 CA A:LEU88 4.4 26.1 1.0 N A:SER84 4.4 33.1 1.0 CB A:LEU88 4.5 30.8 1.0 N A:LEU88 4.6 30.0 1.0 N A:ASN82 4.7 25.6 1.0 CA A:SER84 4.8 31.5 1.0 CA A:PRO85 4.8 38.0 1.0 N A:PRO85 4.8 40.9 1.0 C A:PRO89 4.8 42.4 1.0 N A:ASN90 4.9 45.8 1.0 N A:SER83 4.9 28.6 1.0 CG2 A:ILE81 5.0 24.4 1.0

Calcium binding site 2 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca905 b:66.7 occ:1.00 O B:GLY557 2.6 59.0 1.0 OD1 A:ASP234 2.9 41.6 1.0 C B:GLY557 3.5 57.7 1.0 CG A:ASP234 3.9 42.2 1.0 CA B:GLY557 4.1 55.4 1.0 OD2 A:ASP234 4.2 38.5 1.0 N B:GLU558 4.6 57.7 1.0 O A:GLU231 4.6 40.2 1.0 OE2 B:GLU558 4.8 59.3 1.0 CA B:GLU558 4.9 56.1 1.0

Calcium binding site 3 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1406 b:79.4 occ:1.00 O B:LEU91 2.8 46.8 1.0 O B:LEU88 3.1 38.8 1.0 O B:ASN82 3.2 27.4 1.0 C B:ASN82 3.9 25.2 1.0 C B:LEU91 4.0 44.4 1.0 CA B:ASN82 4.1 23.5 1.0 C B:LEU88 4.2 37.5 1.0 N B:LEU91 4.4 44.5 1.0 O B:ILE81 4.4 24.9 1.0 CA B:PRO89 4.5 40.7 1.0 OD1 B:ASN82 4.5 25.0 1.0 O B:SER84 4.5 36.8 1.0 N B:ASN90 4.6 46.9 1.0 CG2 B:THR92 4.8 40.4 1.0 C B:PRO89 4.8 41.3 1.0 N B:PRO89 4.8 40.2 1.0 CA B:LEU91 4.8 44.5 1.0 CB B:ASN82 4.9 22.5 1.0 N B:THR92 4.9 37.7 1.0

Calcium binding site 4 out of 4 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1407 b:79.8 occ:1.00 O A:GLY557 3.6 58.8 1.0 O B:GLU231 3.7 41.5 1.0 OD1 B:ASP234 3.9 40.3 1.0 OD2 B:ASP234 4.2 41.5 1.0 CG B:ASP234 4.3 41.2 1.0 C A:GLY557 4.6 56.2 1.0 O B:GLU232 4.7 44.8 1.0 C B:GLU231 4.8 39.7 1.0

F.He, C.Wu, Y.Gao, G.Skiniotis. Allosteric Modulation and G-Protein Selectivity of the CA2+-Sensing Receptor Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07055-2