Calcium in PDB 8tqb: MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326

The binding sites of Calcium atom in the MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326 (pdb code 8tqb). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326, PDB code: 8tqb:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1002 b:63.7 occ:1.00 OG A:SER152 3.0 28.4 1.0 NH1 A:ARG277 3.2 27.7 1.0 N A:SER152 3.4 28.4 1.0 CB A:SER152 3.6 28.4 1.0 CB A:TYR222 3.9 24.3 1.0 N A:SER151 4.0 29.6 1.0 CD A:ARG277 4.0 27.7 1.0 N A:TYR222 4.0 24.3 1.0 CA A:SER152 4.2 28.4 1.0 CB A:SER151 4.3 29.6 1.0 CZ A:ARG277 4.3 27.7 1.0 O05 A:W921001 4.4 26.7 1.0 C A:SER151 4.4 29.6 1.0 N A:ASP221 4.4 36.8 1.0 CA A:SER151 4.4 29.6 1.0 CB A:TYR150 4.4 25.2 1.0 CD1 A:TYR150 4.4 25.2 1.0 CG A:ARG277 4.4 27.7 1.0 NE A:ARG277 4.6 27.7 1.0 CA A:TYR222 4.6 24.3 1.0 C A:TYR150 4.7 25.2 1.0 CG A:TYR150 4.8 25.2 1.0 OG A:SER151 4.9 29.6 1.0 OD1 A:ASP221 4.9 36.8 1.0 CA A:TYR150 4.9 25.2 1.0

Calcium binding site 2 out of 4 in the MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1003 b:48.8 occ:1.00 OG1 A:THR98 2.4 34.0 1.0 CB A:THR98 3.2 34.0 1.0 CG2 A:THR98 3.5 34.0 1.0 CG1 A:VAL153 3.5 27.6 1.0 CG2 A:VAL153 3.6 27.6 1.0 N A:SER149 3.7 21.6 1.0 CB A:PRO46 3.8 22.0 1.0 CB A:VAL153 3.8 27.6 1.0 CD2 A:TYR150 3.8 25.2 1.0 N A:PRO46 3.9 22.0 1.0 CD A:PRO46 4.0 22.0 1.0 N A:TYR150 4.1 25.2 1.0 CG A:PRO46 4.1 22.0 1.0 CA A:PRO46 4.1 22.0 1.0 C A:PHE45 4.4 19.1 1.0 CB A:SER149 4.4 21.6 1.0 CB A:TYR150 4.4 25.2 1.0 CA A:SER149 4.4 21.6 1.0 CA A:GLY148 4.5 19.6 1.0 CA A:SER100 4.5 34.3 1.0 C A:SER149 4.6 21.6 1.0 C A:GLY148 4.6 19.6 1.0 CG A:TYR150 4.6 25.2 1.0 CA A:THR98 4.6 34.0 1.0 CE2 A:TYR150 4.7 25.2 1.0 N A:SER100 4.7 34.3 1.0 O A:PHE45 4.9 19.1 1.0 CA A:TYR150 4.9 25.2 1.0 CA A:PHE45 4.9 19.1 1.0

Calcium binding site 3 out of 4 in the MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1002 b:61.9 occ:1.00 OG B:SER152 3.0 27.7 1.0 NH1 B:ARG277 3.2 27.8 1.0 N B:SER152 3.4 27.7 1.0 CB B:SER152 3.6 27.7 1.0 CB B:TYR222 3.9 24.8 1.0 N B:SER151 4.0 29.2 1.0 CD B:ARG277 4.0 27.8 1.0 N B:TYR222 4.0 24.8 1.0 CA B:SER152 4.1 27.7 1.0 CB B:SER151 4.3 29.2 1.0 CZ B:ARG277 4.3 27.8 1.0 O05 B:W921001 4.4 26.6 1.0 C B:SER151 4.4 29.2 1.0 N B:ASP221 4.4 36.9 1.0 CA B:SER151 4.4 29.2 1.0 CB B:TYR150 4.4 24.4 1.0 CD1 B:TYR150 4.4 24.4 1.0 CG B:ARG277 4.4 27.8 1.0 NE B:ARG277 4.6 27.8 1.0 CA B:TYR222 4.6 24.8 1.0 C B:TYR150 4.7 24.4 1.0 CG B:TYR150 4.8 24.4 1.0 OD1 B:ASP221 4.9 36.9 1.0 OG B:SER151 4.9 29.2 1.0 CA B:TYR150 4.9 24.4 1.0

Calcium binding site 4 out of 4 in the MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of MGLUR3 in the Presence of the Agonist LY379268 and Pam VU6023326 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1003 b:49.1 occ:1.00 OG1 B:THR98 2.4 34.1 1.0 CB B:THR98 3.2 34.1 1.0 CG2 B:THR98 3.4 34.1 1.0 CG1 B:VAL153 3.5 27.1 1.0 CG2 B:VAL153 3.6 27.1 1.0 N B:SER149 3.7 20.5 1.0 CB B:PRO46 3.8 21.2 1.0 CB B:VAL153 3.8 27.1 1.0 CD2 B:TYR150 3.8 24.4 1.0 N B:PRO46 3.9 21.2 1.0 CD B:PRO46 4.0 21.2 1.0 N B:TYR150 4.1 24.4 1.0 CG B:PRO46 4.1 21.2 1.0 CA B:PRO46 4.1 21.2 1.0 C B:PHE45 4.4 19.0 1.0 CB B:SER149 4.4 20.5 1.0 CB B:TYR150 4.4 24.4 1.0 CA B:SER149 4.4 20.5 1.0 CA B:GLY148 4.4 19.1 1.0 CA B:SER100 4.5 34.2 1.0 C B:SER149 4.6 20.5 1.0 C B:GLY148 4.6 19.1 1.0 CG B:TYR150 4.6 24.4 1.0 CA B:THR98 4.6 34.1 1.0 CE2 B:TYR150 4.7 24.4 1.0 N B:SER100 4.7 34.2 1.0 CA B:TYR150 4.9 24.4 1.0 O B:PHE45 4.9 19.0 1.0 CA B:PHE45 4.9 19.0 1.0

A.Strauss, A.J.Gonzalez-Hernandez, J.Lee, N.Abreu, P.Selvakumar, L.Salas-Estrada, M.Kristt, D.C.Marx, K.Gilliland, B.J.Melancon, M.Filizola, J.Meyerson, J.Levitz. Structural Basis of Allosteric Modulation of Metabotropic Glutamate Receptor Activation and Desensitization. Biorxiv 2023.
ISSN: ISSN 2692-8205
PubMed: 37645747
DOI: 10.1101/2023.08.13.552748