Calcium in PDB 8we6: Human L-Type Voltage-Gated Calcium Channel CAV1.2 at 2.9 Angstrom Resolution

The binding sites of Calcium atom in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 at 2.9 Angstrom Resolution (pdb code 8we6). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 at 2.9 Angstrom Resolution, PDB code: 8we6:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 at 2.9 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human L-Type Voltage-Gated Calcium Channel CAV1.2 at 2.9 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2301 b:70.1 occ:1.00 OE2 A:GLU363 2.3 69.1 1.0 OE2 A:GLU1135 2.3 67.5 1.0 OE2 A:GLU706 2.4 65.5 1.0 OE1 A:GLU1135 2.8 61.9 1.0 CD A:GLU1135 2.9 62.0 1.0 CD A:GLU363 3.5 68.2 1.0 CD A:GLU706 3.6 61.8 1.0 O A:GLY1463 3.8 67.8 1.0 O A:PHE1134 4.1 59.0 1.0 OE1 A:GLU706 4.2 64.0 1.0 OE1 A:GLU363 4.2 65.4 1.0 CG A:GLU1135 4.3 49.9 1.0 CA A:GLU706 4.5 53.1 1.0 CG A:GLU363 4.6 55.6 1.0 CB A:GLU706 4.6 43.7 1.0 CG A:GLU706 4.7 53.7 1.0 N A:ASP707 4.8 54.8 1.0 CA A:GLU1135 4.8 48.5 1.0 N A:ALA1465 4.9 57.2 1.0 C A:GLY1463 4.9 53.1 1.0 OE2 A:GLU1464 4.9 67.6 1.0 CA A:GLU1464 4.9 45.3 1.0 OE1 A:GLU1464 5.0 63.2 1.0 CD A:GLU1464 5.0 62.5 1.0

Calcium binding site 2 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 at 2.9 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human L-Type Voltage-Gated Calcium Channel CAV1.2 at 2.9 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:70.5 occ:1.00 OG D:SER263 2.3 53.6 1.0 OG1 D:THR331 2.3 71.2 1.0 OD2 A:ASP151 2.5 63.8 1.0 OG D:SER261 3.2 44.0 1.0 CB D:SER263 3.3 48.4 1.0 CB D:THR331 3.4 69.1 1.0 CG A:ASP151 3.4 54.4 1.0 OD1 A:ASP151 3.7 60.4 1.0 CG2 D:THR331 4.2 68.7 1.0 CB D:SER261 4.2 38.8 1.0 N D:SER263 4.3 39.5 1.0 CA D:SER263 4.4 40.5 1.0 OD2 D:ASP259 4.5 58.7 1.0 CA D:THR331 4.6 65.6 1.0 N D:THR331 4.6 64.6 1.0 O D:GLY364 4.7 61.4 1.0 OD1 D:ASP363 4.7 59.3 1.0 CB A:ASP151 4.8 46.5 1.0

S.Gao, X.Yao, J.Chen, G.Huang, X.Fan, L.Xue, Z.Li, T.Wu, Y.Zheng, J.Huang, X.Jin, Y.Wang, Z.Wang, Y.Yu, L.Liu, X.Pan, C.Song, N.Yan. Structural Basis For Human Ca V 1.2 Inhibition By Multiple Drugs and the Neurotoxin Calciseptine. Cell V. 186 5363 2023.
ISSN: ISSN 1097-4172
PubMed: 37972591
DOI: 10.1016/J.CELL.2023.10.007