Calcium in PDB 8we7: Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine at 3.2 Angstrom Resolution

The binding sites of Calcium atom in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine at 3.2 Angstrom Resolution (pdb code 8we7). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine at 3.2 Angstrom Resolution, PDB code: 8we7:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine at 3.2 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine at 3.2 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca2301 b:114.6 occ:1.00 OE2 A:GLU1135 2.4 106.5 1.0 OE2 A:GLU363 2.4 90.4 1.0 OE1 A:GLU1135 2.4 101.4 1.0 OE1 A:GLU363 2.7 92.6 1.0 CD A:GLU1135 2.7 103.9 1.0 CD A:GLU363 2.9 90.7 1.0 OE1 A:GLU706 3.3 87.1 1.0 O A:GLY1463 3.8 100.7 1.0 O A:GLU1464 4.0 95.9 1.0 CD A:GLU706 4.1 92.8 1.0 CG A:GLU1135 4.2 96.7 1.0 O A:PHE1134 4.3 110.5 1.0 CG A:GLU363 4.4 81.6 1.0 OE2 A:GLU706 4.4 96.7 1.0 CA A:GLU1464 4.6 95.9 1.0 OE2 A:GLU1464 4.6 98.6 1.0 CA A:GLU706 4.7 82.0 1.0 C A:GLU1464 4.8 95.7 1.0 N A:ASP707 4.9 82.1 1.0 C A:GLY1463 4.9 93.7 1.0

Calcium binding site 2 out of 2 in the Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine at 3.2 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human L-Type Voltage-Gated Calcium Channel CAV1.2 in the Presence of Calciseptine at 3.2 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:74.8 occ:1.00 OG D:SER263 2.3 63.0 1.0 OD2 A:ASP151 2.4 67.0 1.0 CG2 D:THR331 3.2 76.0 1.0 OG D:SER261 3.3 64.5 1.0 CG A:ASP151 3.4 65.6 1.0 CB D:SER263 3.6 54.6 1.0 CB D:THR331 3.6 71.6 1.0 OD1 A:ASP151 3.7 73.0 1.0 CB D:SER261 3.8 56.5 1.0 OD2 D:ASP259 4.3 76.7 1.0 OD1 D:ASP363 4.4 82.0 1.0 O D:GLY364 4.4 63.9 1.0 OG1 D:THR331 4.4 74.1 1.0 N D:SER263 4.5 39.8 1.0 CA D:SER263 4.7 42.0 1.0 CB A:ASP151 4.7 58.5 1.0 OD2 D:ASP363 4.7 84.5 1.0 N D:THR331 4.8 67.1 1.0 CA D:THR331 4.8 69.2 1.0

S.Gao, X.Yao, J.Chen, G.Huang, X.Fan, L.Xue, Z.Li, T.Wu, Y.Zheng, J.Huang, X.Jin, Y.Wang, Z.Wang, Y.Yu, L.Liu, X.Pan, C.Song, N.Yan. Structural Basis For Human Ca V 1.2 Inhibition By Multiple Drugs and the Neurotoxin Calciseptine. Cell V. 186 5363 2023.
ISSN: ISSN 1097-4172
PubMed: 37972591
DOI: 10.1016/J.CELL.2023.10.007