Calcium in PDB 8wpu: Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein

The structure of Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Calcium atom in the Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein (pdb code 8wpu). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein, PDB code: 8wpu:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1107 b:117.7 occ:1.00 CA B:PRO85 2.8 91.3 1.0 O B:SER84 3.1 88.1 1.0 O B:PRO85 3.3 87.8 1.0 O B:LEU88 3.4 81.6 1.0 C B:PRO85 3.4 89.2 1.0 CA B:PRO89 3.5 86.4 1.0 N B:PRO85 3.7 94.6 1.0 C B:SER84 3.7 87.2 1.0 CB B:PRO85 3.8 91.0 1.0 N B:ASN90 3.8 85.0 1.0 O B:LEU87 4.0 85.1 1.0 C B:LEU88 4.0 80.6 1.0 N B:PRO89 4.0 85.0 1.0 C B:PRO89 4.1 84.9 1.0 O B:ASN82 4.4 65.5 1.0 CD B:PRO89 4.5 86.8 1.0 N B:ALA86 4.6 88.0 1.0 CB B:PRO89 4.7 87.7 1.0 C B:LEU87 4.8 85.7 1.0 CD B:PRO85 5.0 93.8 1.0 CA B:ASN90 5.0 86.2 1.0

Calcium binding site 2 out of 4 in the Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1108 b:113.4 occ:1.00 O B:GLY557 2.4 91.9 1.0 OD1 A:ASP234 2.9 70.0 1.0 C B:GLY557 3.5 89.7 1.0 CG A:ASP234 3.8 66.9 1.0 OD2 A:ASP234 3.9 64.5 1.0 CA B:GLY557 4.0 90.4 1.0 OE2 B:GLU558 4.4 94.0 1.0 O A:GLU231 4.4 61.7 1.0 N B:GLU558 4.6 87.3 1.0 O A:GLU232 4.7 64.9 1.0 CA B:GLU558 4.9 87.9 1.0

Calcium binding site 3 out of 4 in the Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1101 b:98.7 occ:1.00 OD2 B:ASP234 2.7 64.0 1.0 O A:GLY557 2.8 98.3 1.0 C A:GLY557 3.7 93.5 1.0 CG B:ASP234 3.8 62.8 1.0 CA A:GLY557 4.1 94.3 1.0 OD1 B:ASP234 4.1 64.1 1.0 O B:GLU231 4.2 44.9 1.0 O B:GLU232 4.3 55.8 1.0 N A:GLU558 4.8 84.3 1.0

Calcium binding site 4 out of 4 in the Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human Calcium-Sensing Receptor(Casr) Bound to Cinacalcet in Complex with Gq Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1108 b:119.1 occ:1.00 O A:PRO85 2.4 101.3 1.0 N A:LEU88 2.4 87.8 1.0 N A:PRO89 2.5 96.2 1.0 C A:LEU88 2.5 89.8 1.0 C A:PRO85 2.5 101.3 1.0 O A:SER84 2.8 93.5 1.0 CA A:PRO85 2.9 100.0 1.0 CA A:LEU88 3.0 87.9 1.0 CD A:PRO89 3.0 93.9 1.0 O A:LEU88 3.1 89.6 1.0 N A:LEU87 3.1 90.2 1.0 CA A:PRO89 3.2 95.4 1.0 C A:LEU87 3.2 87.0 1.0 N A:ALA86 3.3 95.8 1.0 C A:ALA86 3.5 93.5 1.0 C A:SER84 3.6 92.4 1.0 CA A:LEU87 3.6 88.8 1.0 CB A:PRO89 3.7 93.8 1.0 N A:PRO85 3.7 101.0 1.0 CG A:PRO89 3.9 94.1 1.0 CA A:ALA86 4.0 94.0 1.0 O A:LEU87 4.1 86.0 1.0 CB A:LEU88 4.2 86.3 1.0 O A:ALA86 4.2 93.1 1.0 CB A:PRO85 4.3 98.2 1.0 CB A:LEU87 4.3 88.3 1.0 C A:PRO89 4.5 92.8 1.0 O A:ILE81 4.8 67.1 1.0 OG A:SER84 4.9 89.8 1.0

S.Ling, X.Meng, Y.Zhang, Z.Xia, Y.Zhou, F.Yang, P.Shi, C.Shi, C.Tian. Structural Insights Into Asymmetric Activation of the Calcium-Sensing Receptor-G Q Complex. Cell Res. 2023.
ISSN: ISSN 1001-0602
PubMed: 37919470
DOI: 10.1038/S41422-023-00892-2