Calcium in PDB 9aso: Human Drosha and DGCR8 in Complex with Pri-Let-7A2

All present enzymatic activity of Human Drosha and DGCR8 in Complex with Pri-Let-7A2:
3.1.26.3;

The structure of Human Drosha and DGCR8 in Complex with Pri-Let-7A2 also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Calcium atom in the Human Drosha and DGCR8 in Complex with Pri-Let-7A2 (pdb code 9aso). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Drosha and DGCR8 in Complex with Pri-Let-7A2, PDB code: 9aso:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Drosha and DGCR8 in Complex with Pri-Let-7A2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Drosha and DGCR8 in Complex with Pri-Let-7A2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1403 b:30.0 occ:1.00 OE2 A:GLU1147 2.4 141.8 1.0 OP1 E:U31 2.4 78.6 1.0 O E:HOH201 2.4 30.0 1.0 OE2 A:GLU1222 3.2 141.2 1.0 CD A:GLU1147 3.4 141.8 1.0 OD1 A:ASP1219 3.6 148.2 1.0 OE1 A:GLU1222 3.7 141.2 1.0 CD A:GLU1222 3.7 141.2 1.0 CG A:GLU1147 3.9 141.8 1.0 P E:U31 3.9 76.9 1.0 OE1 A:GLU1147 4.4 141.8 1.0 C5' E:U31 4.5 77.9 1.0 CG A:ASP1219 4.6 148.2 1.0 O5' E:U31 4.6 78.8 1.0 O3' E:U30 4.7 77.2 1.0 OD1 A:ASN1184 4.7 149.4 1.0 OP2 E:U31 4.8 75.2 1.0 CG A:GLU1222 4.9 141.2 1.0

Calcium binding site 2 out of 2 in the Human Drosha and DGCR8 in Complex with Pri-Let-7A2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Drosha and DGCR8 in Complex with Pri-Let-7A2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1404 b:30.0 occ:1.00 OE1 A:GLU1045 2.4 124.2 1.0 OE2 A:GLU969 2.7 30.0 1.0 OD1 A:ASN1042 3.1 127.5 1.0 CD A:GLU1045 3.2 124.2 1.0 OE2 A:GLU1045 3.4 124.2 1.0 CD A:GLU969 3.7 30.0 1.0 CG A:ASN1042 4.1 127.5 1.0 CG A:GLU969 4.1 30.0 1.0 CG A:GLU1045 4.6 124.2 1.0 OD1 A:ASN1006 4.6 129.7 1.0 OE1 A:GLU969 4.7 30.0 1.0 CA A:ASN1042 4.7 127.5 1.0 ND2 A:ASN1042 4.8 127.5 1.0 CB A:ASN1042 4.9 127.5 1.0

A.Garg, L.Joshua-Tor. RNAI_PROTEIN_A2 To Be Published.