Calcium in PDB 9ew7: Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259)

All present enzymatic activity of Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259):
2.7.11.1;

The structure of Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259), PDB code: 9ew7 was solved by M.Konstantinidou, H.Vickery, M.A.M.Pennings, J.Virta, E.J.Visser, M.C.M.Oetelaar, M.Overmans, J.Neitz, C.Ottmann, L.Brunsveld, M.R.Arkin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.43 / 1.80
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	82.375, 112.196, 62.708, 90, 90, 90
R / Rfree (%)	16.4 / 19.3

The structure of Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259) also contains other interesting chemical elements:

Chlorine	(Cl)	1 atom
Magnesium	(Mg)	2 atoms

The binding sites of Calcium atom in the Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259) (pdb code 9ew7). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259), PDB code: 9ew7:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca304 b:43.6 occ:1.00 OE1 A:GLN8 2.8 17.7 1.0 CD A:GLN8 3.8 14.5 1.0 NE2 A:GLN8 4.1 14.2 1.0 O A:HOH472 4.5 13.0 1.0

Calcium binding site 2 out of 2 in the Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Binary Structure of 14-3-3S and Craf Phosphopeptide (PS259) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca305 b:14.5 occ:1.00 O A:GLU110 2.3 8.4 1.0 O A:HOH528 2.3 18.9 1.0 OE2 A:GLU35 2.4 11.4 1.0 O A:HOH594 2.4 13.1 1.0 OE1 A:GLU35 2.6 18.4 1.0 CD A:GLU35 2.8 12.5 1.0 C A:GLU110 3.5 9.5 1.0 N A:GLY112 4.1 11.8 1.0 CG A:GLU35 4.3 10.8 1.0 CA A:GLU110 4.4 10.2 1.0 N A:ALA111 4.4 8.7 1.0 O A:HOH498 4.5 17.7 1.0 CA A:ALA111 4.5 9.2 1.0 CB A:GLU110 4.5 12.8 1.0 OE1 A:GLU110 4.7 25.7 1.0 C A:ALA111 4.7 11.2 1.0 CA A:GLY112 4.8 13.1 1.0 O A:HOH560 4.9 18.1 1.0

M.Konstantinidou, H.Vickery, M.A.M.Pennings, J.Virta, E.J.Visser, M.C.M.Oetelaar, M.Overmans, J.Neitz, C.Ottmann, L.Brunsveld, M.R.Arkin. Small Molecule Stabilization of the 14-3-3SIGMA/Craf Complex Inhibits the Mapk Pathway To Be Published.