Calcium in PDB 9o58: Zymogen ADAM17-IRHOM2 Complex Bound By the MEDI3622 Fab

All present enzymatic activity of Zymogen ADAM17-IRHOM2 Complex Bound By the MEDI3622 Fab:
3.4.24.86;

The structure of Zymogen ADAM17-IRHOM2 Complex Bound By the MEDI3622 Fab also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Calcium atom in the Zymogen ADAM17-IRHOM2 Complex Bound By the MEDI3622 Fab (pdb code 9o58). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Zymogen ADAM17-IRHOM2 Complex Bound By the MEDI3622 Fab, PDB code: 9o58:

Calcium binding site 1 out of 1 in the Zymogen ADAM17-IRHOM2 Complex Bound By the MEDI3622 Fab


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Zymogen ADAM17-IRHOM2 Complex Bound By the MEDI3622 Fab within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca907 b:77.9 occ:1.00 OE2 A:GLU487 2.2 88.9 1.0 OD2 A:ASP490 2.3 81.7 1.0 OD1 A:ASN480 2.3 76.2 1.0 O A:VAL477 2.6 76.3 1.0 O A:ARG482 2.8 77.0 1.0 CA A:CYS478 3.1 84.1 1.0 CG A:ASP490 3.2 81.7 1.0 OD1 A:ASP484 3.2 87.0 1.0 C A:VAL477 3.3 76.3 1.0 CG A:ASN480 3.4 76.2 1.0 CD A:GLU487 3.5 88.9 1.0 N A:CYS478 3.6 84.1 1.0 C A:CYS478 3.7 84.1 1.0 N A:GLY479 3.7 80.8 1.0 OD1 A:ASP490 3.8 81.7 1.0 N A:ASN480 3.9 76.2 1.0 C A:ARG482 4.0 77.0 1.0 CG2 A:VAL477 4.0 76.3 1.0 ND2 A:ASN480 4.0 76.2 1.0 CB A:ASP490 4.2 81.7 1.0 N A:ARG482 4.2 77.0 1.0 CB A:CYS478 4.2 84.1 1.0 CG A:GLU487 4.3 88.9 1.0 OE1 A:GLU487 4.4 88.9 1.0 CG A:ASP484 4.5 87.0 1.0 CB A:ASN480 4.5 76.2 1.0 CA A:ASN480 4.6 76.2 1.0 O A:CYS478 4.6 84.1 1.0 CA A:ARG482 4.6 77.0 1.0 CA A:VAL477 4.6 76.3 1.0 N A:SER481 4.7 77.8 1.0 SG A:CYS478 4.7 84.1 1.0 C A:ASN480 4.7 76.2 1.0 CA A:GLY479 4.8 80.8 1.0 CB A:VAL477 4.8 76.3 1.0 C A:GLY479 4.8 80.8 1.0 CB A:ARG482 4.9 77.0 1.0 N A:ASP484 5.0 87.0 1.0

J.J.Maciag, C.E.Slone, H.F.Alnajjar, M.F.Rich, B.Guion, I.Ifergan, C.P.Blobel, T.C.M.Seegar. Structural Insights Into the Activation and Inhibition of the ADAM17-IRHOM2 Complex. Proc.Natl.Acad.Sci.Usa V. 122 32122 2025.
ISSN: ESSN 1091-6490
PubMed: 40512800
DOI: 10.1073/PNAS.2500732122