Atomistry » Calcium » PDB 1byn-1c5v » 1c5v
Atomistry »
  Calcium »
    PDB 1byn-1c5v »
      1c5v »

Calcium in PDB 1c5v: Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator

Enzymatic activity of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator

All present enzymatic activity of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator:
3.4.21.4;

Protein crystallography data

The structure of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator, PDB code: 1c5v was solved by B.A.Katz, R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang, H.Chan, L.Wong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 7.50 / 1.48
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 54.910, 54.910, 109.200, 90.00, 90.00, 120.00
R / Rfree (%) 19.8 / 22.3

Other elements in 1c5v:

The structure of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator (pdb code 1c5v). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator, PDB code: 1c5v:

Calcium binding site 1 out of 1 in 1c5v

Go back to Calcium Binding Sites List in 1c5v
Calcium binding site 1 out of 1 in the Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca247

b:30.8
occ:1.00
 H2 A:HOH309 1.3 33.4 1.0
O A:HOH309 2.2 33.7 0.2
O A:VAL75 2.3 12.7 1.0
O A:ASN72 2.4 9.2 1.0
OE1 A:GLU70 2.4 11.6 1.0
OE2 A:GLU80 2.4 13.4 1.0
H1 A:HOH309 2.6 35.0 1.0
O A:HOH271 2.7 17.6 1.0
H A:GLU77 2.9 19.6 1.0
HA A:VAL76 3.1 16.7 1.0
H2 A:HOH271 3.2 19.2 1.0
C A:VAL75 3.3 13.0 1.0
HG3 A:GLU77 3.4 22.0 1.0
H A:VAL75 3.4 11.1 1.0
CD A:GLU70 3.4 12.8 1.0
H A:ASP71 3.4 14.4 1.0
H1 A:HOH271 3.5 20.1 1.0
HG2 A:GLU80 3.5 15.1 1.0
CD A:GLU80 3.5 15.2 1.0
C A:ASN72 3.6 11.8 1.0
HA A:ILE73 3.6 10.1 1.0
HB3 A:ASN72 3.7 14.0 1.0
H A:ASN72 3.7 11.5 1.0
OE2 A:GLU70 3.8 14.3 1.0
HA A:GLU70 3.8 10.1 1.0
N A:GLU77 3.8 18.6 1.0
OE1 A:GLU77 3.9 20.4 1.0
CG A:GLU80 3.9 16.0 1.0
CA A:VAL76 3.9 16.6 1.0
HG3 A:GLU80 4.0 15.5 1.0
N A:VAL76 4.0 13.2 1.0
HB2 A:GLU77 4.1 20.3 1.0
N A:VAL75 4.1 10.3 1.0
N A:ASN72 4.1 10.2 1.0
CG A:GLU77 4.2 21.6 1.0
CA A:VAL75 4.3 11.8 1.0
HB A:VAL75 4.3 8.9 1.0
CA A:ASN72 4.4 11.0 1.0
CA A:ILE73 4.4 8.9 1.0
C A:VAL76 4.4 17.6 1.0
N A:ASP71 4.4 16.5 1.0
N A:ILE73 4.5 9.0 1.0
O A:HOH267 4.5 16.3 1.0
CB A:ASN72 4.5 14.9 1.0
OE1 A:GLU80 4.5 13.3 1.0
CD A:GLU77 4.5 24.9 1.0
CB A:GLU77 4.5 20.4 1.0
HB3 A:GLU70 4.6 11.7 1.0
C A:ILE73 4.7 10.3 1.0
CA A:GLU70 4.7 10.8 1.0
CG A:GLU70 4.7 13.0 1.0
H1 A:HOH267 4.7 17.8 1.0
H A:ASN74 4.8 11.8 1.0
O A:HOH299 4.8 17.2 1.0
CA A:GLU77 4.8 20.4 1.0
HG22 A:VAL76 4.9 21.1 1.0
N A:ASN74 4.9 12.3 1.0
CB A:GLU70 4.9 10.9 1.0
CB A:VAL75 4.9 10.5 1.0
HZ A:PHE82 4.9 16.5 1.0
H A:VAL76 4.9 14.4 1.0
C A:ASP71 4.9 13.2 1.0
H2 A:HOH268 5.0 7.4 1.0

Reference:

B.A.Katz, R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang, H.Chan, L.Wong. Structural Basis For Selectivity of A Small Molecule, S1-Binding, Submicromolar Inhibitor of Urokinase-Type Plasminogen Activator. Chem.Biol. V. 7 299 2000.
ISSN: ISSN 1074-5521
PubMed: 10779411
DOI: 10.1016/S1074-5521(00)00104-6
Page generated: Thu Jul 11 06:51:29 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy