Calcium in PDB 1esv: Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1

The structure of Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1, PDB code: 1esv was solved by W.M.Morton, K.A.Ayscough, P.J.Mclaughlin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.70 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.750, 69.250, 182.910, 90.00, 90.00, 90.00
R / Rfree (%)	22.8 / 28.6

The binding sites of Calcium atom in the Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1 (pdb code 1esv). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1, PDB code: 1esv:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1 within 5.0Å range: probe atom residue distance (Å) B Occ S:Ca390 b:64.8 occ:1.00 O A:HOH1263 1.9 24.9 0.5 OD2 S:ASP85 2.2 24.8 1.0 O S:ALA92 2.2 31.6 1.0 OD1 S:ASP85 2.6 28.0 1.0 CG S:ASP85 2.7 21.4 1.0 O S:GLY90 3.0 23.7 1.0 OE1 A:GLU167 3.1 34.9 1.0 C S:ALA92 3.4 29.4 1.0 C S:GLY90 3.6 18.4 1.0 N S:ALA92 3.6 29.4 1.0 O S:HOH1389 3.8 45.6 0.5 O S:HOH1424 3.9 46.8 0.5 CD A:GLU167 4.0 37.9 1.0 CA S:ALA92 4.0 28.6 1.0 CA S:GLY90 4.0 15.4 1.0 CB S:ASP85 4.2 14.1 1.0 OE2 A:GLU167 4.3 36.8 1.0 C S:ARG91 4.3 35.9 1.0 N S:VAL93 4.5 34.1 1.0 N S:ARG91 4.5 18.5 1.0 CB S:ALA92 4.5 17.6 1.0 O S:HOH1223 4.7 51.2 1.0 NE2 S:GLN94 4.7 19.2 1.0 CA S:VAL93 4.8 28.3 1.0 CA S:ARG91 4.8 26.4 1.0 CG S:GLN94 4.8 23.4 1.0 O S:HOH1386 4.8 33.3 0.5

Calcium binding site 2 out of 3 in the Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1 within 5.0Å range: probe atom residue distance (Å) B Occ S:Ca395 b:48.2 occ:1.00 O S:GLY41 2.2 26.8 1.0 OD2 S:ASP42 2.3 29.0 1.0 O S:VAL121 2.3 35.5 1.0 OE2 S:GLU73 2.6 28.2 1.0 OE1 S:GLU73 2.7 22.8 1.0 O S:HOH1306 2.9 37.9 1.0 CD S:GLU73 3.0 27.5 1.0 C S:GLY41 3.3 30.0 1.0 C S:VAL121 3.4 31.6 1.0 CG S:ASP42 3.5 27.8 1.0 N S:VAL121 3.6 38.2 1.0 CG1 S:VAL121 3.7 24.0 1.0 CA S:ASP42 3.7 29.2 1.0 O S:HOH1136 3.9 53.7 1.0 CA S:VAL121 4.0 28.4 1.0 N S:ASP42 4.0 21.0 1.0 O S:HOH1002 4.0 32.2 1.0 C S:GLY120 4.1 46.2 1.0 CB S:ASP42 4.2 26.4 1.0 CA S:GLY41 4.3 24.8 1.0 OD1 S:ASP42 4.4 42.5 1.0 CA S:GLY120 4.5 44.3 1.0 CG S:GLU73 4.5 17.4 1.0 N S:ALA122 4.5 32.4 1.0 CB S:VAL121 4.5 30.0 1.0 CA S:CYS69 4.7 16.8 1.0 O S:GLY120 4.8 45.5 1.0 O S:HOH1029 4.9 28.7 1.0 C S:ALA122 4.9 34.1 1.0 CB S:CYS69 4.9 17.4 1.0 N S:SER70 4.9 21.3 1.0 CA S:ALA122 4.9 35.0 1.0 OG S:SER70 4.9 31.2 1.0 C S:ASP42 4.9 22.9 1.0 N S:SER123 5.0 37.8 1.0

Calcium binding site 3 out of 3 in the Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Complex Between Latrunculin A:Rabbit Muscle Alpha Actin:Human Gelsolin Domain 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca385 b:24.3 occ:1.00 O A:HOH1065 2.2 23.2 1.0 O3G A:ATP380 2.2 28.5 1.0 O A:HOH1004 2.2 29.0 1.0 O2B A:ATP380 2.3 34.8 1.0 O A:HOH1007 2.4 21.1 1.0 O A:HOH1033 2.6 21.9 1.0 O A:HOH1009 2.8 25.2 1.0 PG A:ATP380 3.4 31.2 1.0 PB A:ATP380 3.6 29.3 1.0 O3B A:ATP380 3.8 32.0 1.0 O1G A:ATP380 3.9 27.8 1.0 O A:HOH1071 4.0 29.6 1.0 NZ A:LYS18 4.2 18.5 1.0 O1A A:ATP380 4.2 26.0 1.0 O3A A:ATP380 4.2 37.3 1.0 CA A:GLY13 4.4 29.4 1.0 OE1 A:GLN137 4.4 28.6 1.0 O A:HOH1039 4.5 24.4 1.0 OD2 A:ASP11 4.5 29.1 1.0 OD1 A:ASP154 4.6 29.6 1.0 CD A:GLN137 4.6 24.0 1.0 OD1 A:ASP11 4.7 34.2 1.0 O2G A:ATP380 4.7 26.5 1.0 O A:HOH1138 4.7 46.8 1.0 PA A:ATP380 4.7 29.7 1.0 O1B A:ATP380 4.8 26.9 1.0 NE2 A:GLN137 4.9 17.9 1.0

W.M.Morton, K.R.Ayscough, P.J.Mclaughlin. Latrunculin Alters the Actin-Monomer Subunit Interface to Prevent Polymerization. Nat.Cell Biol. V. 2 376 2000.
ISSN: ISSN 1465-7392
PubMed: 10854330
DOI: 10.1038/35014075