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Calcium in PDB 1f0s: Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707

Enzymatic activity of Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707

All present enzymatic activity of Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707:
3.4.21.6;

Protein crystallography data

The structure of Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707, PDB code: 1f0s was solved by S.Maignan, J.P.Guilloteau, S.Pouzieux, Y.M.Choi-Sledeski, M.R.Becker, S.I.Klein, W.R.Ewing, H.W.Pauls, A.P.Spada, V.Mikol, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 55.660, 71.580, 78.700, 90.00, 90.00, 90.00
R / Rfree (%) 21.6 / 26.3

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707 (pdb code 1f0s). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707, PDB code: 1f0s:

Calcium binding site 1 out of 1 in 1f0s

Go back to Calcium Binding Sites List in 1f0s
Calcium binding site 1 out of 1 in the Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Coagulation Factor Xa Complexed with RPR208707 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca301

b:48.5
occ:1.00
OE1 A:GLU80 2.4 31.2 1.0
O A:ASN72 2.4 41.7 1.0
OD1 A:ASP70 2.5 39.0 1.0
O A:HOH468 2.6 33.5 1.0
O A:HOH488 2.7 42.2 1.0
O A:GLN75 2.9 66.5 1.0
C A:ASN72 3.3 33.9 1.0
CD A:GLU80 3.4 27.9 1.0
C A:GLN75 3.6 61.7 1.0
CG A:ASP70 3.7 36.5 1.0
N A:ASN72 3.7 32.2 1.0
CG A:GLU80 3.9 25.8 1.0
N A:GLU77 3.9 61.2 1.0
CA A:ASN72 4.0 32.5 1.0
N A:THR73 4.1 35.1 1.0
CA A:GLU76 4.1 62.3 1.0
N A:GLU76 4.2 61.9 1.0
CA A:THR73 4.3 37.3 1.0
N A:ARG71 4.3 25.3 1.0
CB A:ASN72 4.3 32.2 1.0
N A:GLN75 4.3 55.9 1.0
OD2 A:ASP70 4.4 43.1 1.0
OE2 A:GLU80 4.5 32.6 1.0
C A:GLU76 4.6 62.1 1.0
CA A:GLN75 4.6 58.3 1.0
CB A:GLU77 4.6 55.5 1.0
CA A:ASP70 4.7 30.7 1.0
C A:THR73 4.8 41.5 1.0
N A:GLU74 4.8 46.2 1.0
CB A:ASP70 4.8 36.0 1.0
CA A:GLU77 4.9 58.0 1.0
C A:ARG71 4.9 26.9 1.0

Reference:

S.Maignan, J.P.Guilloteau, S.Pouzieux, Y.M.Choi-Sledeski, M.R.Becker, S.I.Klein, W.R.Ewing, H.W.Pauls, A.P.Spada, V.Mikol. Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors. J.Med.Chem. V. 43 3226 2000.
ISSN: ISSN 0022-2623
PubMed: 10966741
DOI: 10.1021/JM000940U
Page generated: Sat Dec 12 02:54:53 2020

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