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Calcium in PDB 1hfs: Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004
Enzymatic activity of Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004
All present enzymatic activity of Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004:
3.4.24.17;
3.4.24.17;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004, PDB code: 1hfs
was solved by
J.W.Becker,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.70 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 84.140, 85.350, 55.260, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.9 / 21.7 |
Other elements in 1hfs:
The structure of Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004 also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Zinc | (Zn) | 2 atoms |
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004
(pdb code 1hfs). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004, PDB code: 1hfs:
Jump to Calcium binding site number: 1; 2; 3;
In total 3 binding sites of Calcium where determined in the Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004, PDB code: 1hfs:
Jump to Calcium binding site number: 1; 2; 3;
Calcium binding site 1 out of 3 in 1hfs
Go back to
Calcium Binding Sites List in 1hfs
Calcium binding site 1 out
of 3 in the Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004 within 5.0Å range:
|
Calcium binding site 2 out of 3 in 1hfs
Go back to
Calcium Binding Sites List in 1hfs
Calcium binding site 2 out
of 3 in the Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004 within 5.0Å range:
|
Calcium binding site 3 out of 3 in 1hfs
Go back to
Calcium Binding Sites List in 1hfs
Calcium binding site 3 out
of 3 in the Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Crystal Structure of the Catalytic Domain of Human Fibroblast Stromelysin-1 Inhibited with the N-Carboxy-Alkyl Inhibitor L-764,004 within 5.0Å range:
|
Reference:
C.K.Esser,
R.L.Bugianesi,
C.G.Caldwell,
K.T.Chapman,
P.L.Durette,
N.N.Girotra,
I.E.Kopka,
T.J.Lanza,
D.A.Levorse,
M.Maccoss,
K.A.Owens,
M.M.Ponpipom,
J.P.Simeone,
R.K.Harrison,
L.Niedzwiecki,
J.W.Becker,
A.I.Marcy,
M.G.Axel,
A.J.Christen,
J.Mcdonnell,
V.L.Moore,
J.M.Olszewski,
C.Saphos,
D.M.Visco,
F.Shen,
A.Colletti,
P.A.Krieter,
W.K.Hagmann.
Inhibition of Stromelysin-1 (Mmp-3) By P1'-Biphenylylethyl Carboxyalkyl Dipeptides. J.Med.Chem. V. 40 1026 1997.
ISSN: ISSN 0022-2623
PubMed: 9083493
DOI: 10.1021/JM960465T
Page generated: Sat Dec 12 02:59:21 2020
ISSN: ISSN 0022-2623
PubMed: 9083493
DOI: 10.1021/JM960465T
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