Calcium in PDB 1hov: Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020
Enzymatic activity of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020
All present enzymatic activity of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020:
3.4.24.24;
Other elements in 1hov:
The structure of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020 also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020
(pdb code 1hov). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the
Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020, PDB code: 1hov:
Jump to Calcium binding site number:
1;
2;
Calcium binding site 1 out
of 2 in 1hov
Go back to
Calcium Binding Sites List in 1hov
Calcium binding site 1 out
of 2 in the Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca167
b:9.1
occ:1.00
|
OE2
|
A:GLU103
|
2.5
|
0.0
|
1.0
|
O
|
A:LYS79
|
2.5
|
0.0
|
1.0
|
O
|
A:ASP80
|
2.6
|
0.0
|
1.0
|
O
|
A:LEU82
|
2.6
|
0.0
|
1.0
|
O
|
A:GLY78
|
2.6
|
0.0
|
1.0
|
OD2
|
A:ASP77
|
2.6
|
0.0
|
1.0
|
OD2
|
A:ASP100
|
2.7
|
0.0
|
1.0
|
CG
|
A:ASP100
|
2.8
|
0.0
|
1.0
|
OD1
|
A:ASP100
|
2.9
|
0.0
|
1.0
|
OD1
|
A:ASP77
|
2.9
|
0.0
|
1.0
|
CG
|
A:ASP77
|
3.1
|
0.0
|
1.0
|
OE1
|
A:GLU103
|
3.1
|
0.0
|
1.0
|
HG
|
A:LEU82
|
3.1
|
0.0
|
1.0
|
CD
|
A:GLU103
|
3.2
|
0.0
|
1.0
|
C
|
A:GLY78
|
3.4
|
0.0
|
1.0
|
C
|
A:LYS79
|
3.6
|
0.0
|
1.0
|
C
|
A:ASP80
|
3.7
|
0.0
|
1.0
|
C
|
A:LEU82
|
3.7
|
0.0
|
1.0
|
HD22
|
A:LEU83
|
3.8
|
0.0
|
1.0
|
HA2
|
A:GLY78
|
3.8
|
0.0
|
1.0
|
HA
|
A:LEU83
|
3.9
|
0.0
|
1.0
|
CB
|
A:ASP100
|
3.9
|
0.0
|
1.0
|
CA
|
A:GLY78
|
4.0
|
0.0
|
1.0
|
N
|
A:GLY78
|
4.0
|
0.0
|
1.0
|
HB2
|
A:ASP100
|
4.0
|
0.0
|
1.0
|
HB3
|
A:ASP100
|
4.0
|
0.0
|
1.0
|
H
|
A:GLY78
|
4.0
|
0.0
|
1.0
|
HA
|
A:ASP80
|
4.1
|
0.0
|
1.0
|
CG
|
A:LEU82
|
4.2
|
0.0
|
1.0
|
N
|
A:LYS79
|
4.2
|
0.0
|
1.0
|
CA
|
A:ASP80
|
4.3
|
0.0
|
1.0
|
N
|
A:LEU82
|
4.3
|
0.0
|
1.0
|
HD23
|
A:LEU83
|
4.4
|
0.0
|
1.0
|
N
|
A:ASP80
|
4.4
|
0.0
|
1.0
|
HH2
|
A:TRP105
|
4.4
|
0.0
|
1.0
|
C
|
A:GLY81
|
4.4
|
0.0
|
1.0
|
C
|
A:ASP77
|
4.5
|
0.0
|
1.0
|
H
|
A:LEU82
|
4.5
|
0.0
|
1.0
|
CA
|
A:LEU82
|
4.5
|
0.0
|
1.0
|
CA
|
A:LYS79
|
4.5
|
0.0
|
1.0
|
CD2
|
A:LEU83
|
4.6
|
0.0
|
1.0
|
CB
|
A:ASP77
|
4.6
|
0.0
|
1.0
|
HD23
|
A:LEU82
|
4.6
|
0.0
|
1.0
|
CG
|
A:GLU103
|
4.6
|
0.0
|
1.0
|
O
|
A:GLY81
|
4.7
|
0.0
|
1.0
|
N
|
A:GLY81
|
4.7
|
0.0
|
1.0
|
N
|
A:LEU83
|
4.7
|
0.0
|
1.0
|
HA3
|
A:GLY81
|
4.7
|
0.0
|
1.0
|
CA
|
A:LEU83
|
4.8
|
0.0
|
1.0
|
HD13
|
A:LEU82
|
4.8
|
0.0
|
1.0
|
CA
|
A:GLY81
|
4.9
|
0.0
|
1.0
|
O
|
A:ASP77
|
4.9
|
0.0
|
1.0
|
CB
|
A:LEU82
|
4.9
|
0.0
|
1.0
|
HG2
|
A:GLU103
|
4.9
|
0.0
|
1.0
|
CD1
|
A:LEU82
|
4.9
|
0.0
|
1.0
|
HB2
|
A:ASP77
|
5.0
|
0.0
|
1.0
|
HD12
|
A:LEU82
|
5.0
|
0.0
|
1.0
|
CD2
|
A:LEU82
|
5.0
|
0.0
|
1.0
|
|
Calcium binding site 2 out
of 2 in 1hov
Go back to
Calcium Binding Sites List in 1hov
Calcium binding site 2 out
of 2 in the Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Solution Structure of A Catalytic Domain of Mmp-2 Complexed with Sc-74020 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca168
b:8.1
occ:1.00
|
OD1
|
A:ASP96
|
2.4
|
0.0
|
1.0
|
O
|
A:ASP60
|
2.5
|
0.0
|
1.0
|
O
|
A:GLY92
|
2.5
|
0.0
|
1.0
|
O
|
A:GLY94
|
2.5
|
0.0
|
1.0
|
HA3
|
A:GLY95
|
2.6
|
0.0
|
1.0
|
C
|
A:GLY94
|
2.7
|
0.0
|
1.0
|
H
|
A:ASP96
|
2.8
|
0.0
|
1.0
|
CG
|
A:ASP96
|
2.8
|
0.0
|
1.0
|
N
|
A:GLY95
|
2.8
|
0.0
|
1.0
|
HA
|
A:ILE61
|
2.8
|
0.0
|
1.0
|
N
|
A:ASP96
|
2.8
|
0.0
|
1.0
|
C
|
A:GLY95
|
2.8
|
0.0
|
1.0
|
CA
|
A:GLY95
|
2.9
|
0.0
|
1.0
|
OD2
|
A:ASP96
|
3.0
|
0.0
|
1.0
|
O
|
A:VAL93
|
3.2
|
0.0
|
1.0
|
H
|
A:MET62
|
3.2
|
0.0
|
1.0
|
C
|
A:VAL93
|
3.3
|
0.0
|
1.0
|
C
|
A:GLY92
|
3.4
|
0.0
|
1.0
|
H
|
A:GLY95
|
3.5
|
0.0
|
1.0
|
N
|
A:GLY94
|
3.5
|
0.0
|
1.0
|
O
|
A:GLY95
|
3.6
|
0.0
|
1.0
|
C
|
A:ASP60
|
3.6
|
0.0
|
1.0
|
CA
|
A:GLY94
|
3.7
|
0.0
|
1.0
|
CA
|
A:ASP96
|
3.8
|
0.0
|
1.0
|
CA
|
A:ILE61
|
3.8
|
0.0
|
1.0
|
CB
|
A:ASP96
|
3.9
|
0.0
|
1.0
|
HA
|
A:ASP96
|
3.9
|
0.0
|
1.0
|
N
|
A:MET62
|
4.0
|
0.0
|
1.0
|
HA2
|
A:GLY95
|
4.0
|
0.0
|
1.0
|
HG23
|
A:ILE61
|
4.0
|
0.0
|
1.0
|
CA
|
A:VAL93
|
4.0
|
0.0
|
1.0
|
HA
|
A:VAL93
|
4.1
|
0.0
|
1.0
|
H
|
A:GLY94
|
4.1
|
0.0
|
1.0
|
N
|
A:VAL93
|
4.1
|
0.0
|
1.0
|
N
|
A:ILE61
|
4.2
|
0.0
|
1.0
|
HA2
|
A:GLY94
|
4.3
|
0.0
|
1.0
|
SD
|
A:MET62
|
4.3
|
0.0
|
1.0
|
CA
|
A:GLY92
|
4.3
|
0.0
|
1.0
|
HE1
|
A:TRP11
|
4.3
|
0.0
|
1.0
|
C
|
A:ILE61
|
4.3
|
0.0
|
1.0
|
HA2
|
A:GLY92
|
4.4
|
0.0
|
1.0
|
H
|
A:GLY92
|
4.4
|
0.0
|
1.0
|
HB2
|
A:MET62
|
4.4
|
0.0
|
1.0
|
N
|
A:GLY92
|
4.4
|
0.0
|
1.0
|
HB2
|
A:ASP96
|
4.5
|
0.0
|
1.0
|
HA3
|
A:GLY94
|
4.5
|
0.0
|
1.0
|
HG3
|
A:MET62
|
4.5
|
0.0
|
1.0
|
HB3
|
A:ASP96
|
4.6
|
0.0
|
1.0
|
HA
|
A:ASP60
|
4.7
|
0.0
|
1.0
|
CA
|
A:ASP60
|
4.8
|
0.0
|
1.0
|
O
|
A:GLY90
|
4.8
|
0.0
|
1.0
|
CG
|
A:MET62
|
4.8
|
0.0
|
1.0
|
CG2
|
A:ILE61
|
4.8
|
0.0
|
1.0
|
H
|
A:VAL93
|
4.9
|
0.0
|
1.0
|
CB
|
A:ILE61
|
5.0
|
0.0
|
1.0
|
O
|
A:ALA59
|
5.0
|
0.0
|
1.0
|
CB
|
A:MET62
|
5.0
|
0.0
|
1.0
|
|
Reference:
Y.Feng,
J.J.Likos,
L.Zhu,
H.Woodward,
G.Munie,
J.J.Mcdonald,
A.M.Stevens,
C.P.Howard,
G.A.De Crescenzo,
D.Welsch,
H.-S.Shieh,
W.C.Stallings.
Solution Structure and Backbone Dynamics of the Catalytic Domain of Matrix Metalloproteinase-2 Complexed with A Hydroxamic Acid Inhibitor Biochim.Biophys.Acta V.1598 10 2002.
ISSN: ISSN 0006-3002
PubMed: 12147339
DOI: 10.1016/S0167-4838(02)00307-2
Page generated: Thu Jul 11 10:07:38 2024
|