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Calcium in PDB 1hp0: Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine

Enzymatic activity of Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine

All present enzymatic activity of Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine:
3.2.2.1;

Protein crystallography data

The structure of Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine, PDB code: 1hp0 was solved by W.Versees, K.Decanniere, R.Pelle, J.Depoorter, D.W.Parkin, J.Steyaert, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 51.670, 74.290, 81.510, 90.00, 103.54, 90.00
R / Rfree (%) 19.1 / 25.4

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine (pdb code 1hp0). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine, PDB code: 1hp0:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 1hp0

Go back to Calcium Binding Sites List in 1hp0
Calcium binding site 1 out of 2 in the Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca328

b:21.6
occ:1.00
 O A:THR137 2.3 20.5 1.0
OD2 A:ASP261 2.5 17.1 1.0
OD2 A:ASP10 2.5 22.8 1.0
OD2 A:ASP15 2.5 19.9 1.0
O2' A:AD31315 2.6 25.4 1.0
O A:HOH1316 2.6 23.9 1.0
O3' A:AD31315 2.6 24.4 1.0
OD1 A:ASP15 2.6 19.3 1.0
CG A:ASP15 2.9 18.2 1.0
CG A:ASP261 3.4 17.7 1.0
C A:THR137 3.4 20.5 1.0
C2' A:AD31315 3.4 23.8 1.0
C3' A:AD31315 3.5 24.7 1.0
CG A:ASP10 3.5 21.7 1.0
OD1 A:ASP261 3.6 18.4 1.0
OD1 A:ASP10 3.9 22.8 1.0
CA A:GLY138 4.2 19.1 1.0
N A:GLY138 4.2 20.6 1.0
CB A:THR137 4.2 18.2 1.0
OD1 A:ASP14 4.3 22.8 1.0
C1' A:AD31315 4.3 26.4 1.0
CB A:ASP15 4.3 20.4 1.0
OG1 A:THR137 4.3 18.3 1.0
C4' A:AD31315 4.3 25.0 1.0
CA A:THR137 4.4 18.5 1.0
OD1 A:ASN186 4.4 23.5 1.0
OD2 A:ASP14 4.5 18.5 1.0
N A:ASP10 4.6 24.2 1.0
ND2 A:ASN186 4.6 21.3 1.0
CG A:ASP14 4.7 22.6 1.0
CB A:ASP261 4.8 18.5 1.0
CB A:ASN12 4.8 24.0 1.0
CB A:ASP10 4.8 24.3 1.0
O4' A:AD31315 4.8 28.2 1.0
CA A:ASP15 4.9 18.7 1.0
N A:ASP15 4.9 21.3 1.0
N A:ASN12 5.0 21.5 1.0
CG A:ASN186 5.0 25.7 1.0

Calcium binding site 2 out of 2 in 1hp0

Go back to Calcium Binding Sites List in 1hp0
Calcium binding site 2 out of 2 in the Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of An Inosine-Adenosine-Guanosine- Preferring Nucleoside Hydrolase From Trypanosoma Vivax in Complex with the Substrate Analogue 3-Deaza-Adenosine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca328

b:23.8
occ:1.00
 OD2 B:ASP15 2.4 26.4 1.0
O2' B:AD31316 2.4 23.5 1.0
OD2 B:ASP261 2.4 21.4 1.0
O3' B:AD31316 2.4 26.1 1.0
O B:THR137 2.4 23.7 1.0
OD2 B:ASP10 2.5 24.8 1.0
O B:HOH1317 2.5 19.9 1.0
OD1 B:ASP15 2.7 21.0 1.0
CG B:ASP15 2.9 25.2 1.0
C2' B:AD31316 3.3 27.7 1.0
CG B:ASP261 3.4 18.9 1.0
C3' B:AD31316 3.4 27.5 1.0
CG B:ASP10 3.5 23.5 1.0
C B:THR137 3.5 24.4 1.0
OD1 B:ASP261 3.6 20.9 1.0
OD1 B:ASP10 3.8 22.2 1.0
C1' B:AD31316 4.2 30.7 1.0
CB B:THR137 4.3 23.6 1.0
CA B:GLY138 4.3 25.9 1.0
OD1 B:ASP14 4.3 28.2 1.0
CB B:ASP15 4.3 20.3 1.0
N B:GLY138 4.3 25.5 1.0
C4' B:AD31316 4.4 26.7 1.0
OG1 B:THR137 4.4 21.2 1.0
OD1 B:ASN186 4.4 24.9 1.0
ND2 B:ASN186 4.5 23.5 1.0
CA B:THR137 4.5 24.0 1.0
CB B:ASN12 4.6 31.4 1.0
OD2 B:ASP14 4.6 24.6 1.0
N B:ASP10 4.7 24.3 1.0
CB B:ASP261 4.7 19.5 1.0
CG B:ASP14 4.8 25.3 1.0
CB B:ASP10 4.8 23.7 1.0
O4' B:AD31316 4.8 30.6 1.0
N B:ASP15 4.9 21.2 1.0
CA B:ASP15 4.9 22.1 1.0
CG B:ASN186 4.9 24.3 1.0
N B:ASN12 4.9 26.2 1.0

Reference:

W.Versees, K.Decanniere, R.Pelle, J.Depoorter, E.Brosens, D.W.Parkin, J.Steyaert. Structure and Function of A Novel Purine Specific Nucleoside Hydrolase From Trypanosoma Vivax. J.Mol.Biol. V. 307 1363 2001.
ISSN: ISSN 0022-2836
PubMed: 11292348
DOI: 10.1006/JMBI.2001.4548
Page generated: Thu Jul 11 10:07:37 2024

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