Calcium in PDB 1hvd: Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter

The structure of Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter, PDB code: 1hvd was solved by A.Burger, R.Huber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	N/A / 2.00
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	99.600, 99.600, 96.600, 90.00, 90.00, 120.00
R / Rfree (%)	18.9 / n/a

The binding sites of Calcium atom in the Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter (pdb code 1hvd). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter, PDB code: 1hvd:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca600 b:47.5 occ:1.00 O A:GLY102 2.0 34.9 1.0 O A:LEU100 2.1 37.4 1.0 O A:GLY104 2.1 38.4 1.0 OD2 A:ASP144 2.4 39.7 1.0 OG1 A:THR105 3.0 36.2 1.0 O A:LYS101 3.1 40.4 1.0 C A:GLY102 3.2 35.1 1.0 C A:LEU100 3.3 30.7 1.0 C A:GLY104 3.3 34.4 1.0 CG A:ASP144 3.5 33.7 1.0 C A:LYS101 3.6 38.4 1.0 N A:GLY102 3.9 38.6 1.0 OD1 A:ASP144 4.0 43.2 1.0 CB A:THR105 4.1 26.2 1.0 CA A:THR105 4.1 28.3 1.0 C A:ALA103 4.1 29.0 1.0 N A:THR105 4.2 30.2 1.0 CA A:GLY102 4.2 36.0 1.0 N A:LYS101 4.2 32.4 1.0 N A:GLY104 4.2 30.1 1.0 N A:ALA103 4.2 31.9 1.0 CA A:LYS101 4.3 38.7 1.0 CA A:LEU100 4.3 26.8 1.0 O A:HOH478 4.3 56.1 1.0 O A:ALA103 4.3 29.2 1.0 CA A:GLY104 4.4 32.8 1.0 CA A:ALA103 4.5 30.6 1.0 CB A:ASP144 4.6 30.4 1.0 O A:ALA99 4.7 23.4 1.0

Calcium binding site 2 out of 4 in the Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca601 b:37.6 occ:1.00 O A:HOH483 2.0 41.4 1.0 O A:GLY263 2.0 27.1 1.0 O A:MET259 2.1 26.4 1.0 O A:GLY261 2.1 33.7 1.0 OD1 A:ASP303 3.0 24.2 1.0 C A:GLY263 3.2 27.0 1.0 C A:MET259 3.3 23.2 1.0 C A:GLY261 3.3 28.2 1.0 OD2 A:ASP303 3.4 27.9 1.0 CG A:ASP303 3.6 24.3 1.0 N A:GLY263 3.8 25.8 1.0 N A:GLY261 4.0 30.8 1.0 C A:LYS260 4.0 30.3 1.0 CA A:GLY263 4.1 27.9 1.0 CA A:MET259 4.1 18.8 1.0 C A:ALA262 4.1 25.6 1.0 OG1 A:THR264 4.2 21.2 1.0 O A:LYS260 4.2 28.7 1.0 N A:LYS260 4.3 25.2 1.0 CA A:GLY261 4.3 31.7 1.0 N A:THR264 4.3 25.0 1.0 N A:ALA262 4.3 25.3 1.0 CA A:LYS260 4.5 30.0 1.0 CA A:ALA262 4.5 27.8 1.0 CA A:THR264 4.5 21.4 1.0 O A:ALA262 4.6 26.6 1.0 CB A:MET259 4.8 16.7 1.0 O A:HOH494 4.9 58.1 1.0 CB A:THR264 4.9 20.6 1.0

Calcium binding site 3 out of 4 in the Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca602 b:37.1 occ:1.00 O A:MET28 2.1 22.0 1.0 O A:GLY30 2.1 32.0 1.0 O A:GLY32 2.2 35.8 1.0 OE1 A:GLU72 2.5 26.2 1.0 O A:HOH417 2.6 34.0 1.0 OE2 A:GLU72 3.1 29.9 1.0 CD A:GLU72 3.2 22.7 1.0 C A:GLY30 3.3 31.8 1.0 C A:MET28 3.3 19.8 1.0 C A:GLY32 3.5 36.2 1.0 N A:GLY30 3.7 27.1 1.0 O A:HOH436 3.9 42.0 1.0 C A:LYS29 3.9 26.0 1.0 N A:GLY32 4.0 37.4 1.0 CA A:GLY30 4.1 30.9 1.0 N A:LYS29 4.2 23.5 1.0 CA A:LYS29 4.3 25.4 1.0 O A:LYS29 4.3 25.8 1.0 CA A:GLY32 4.3 38.6 1.0 CA A:MET28 4.4 17.4 1.0 N A:LEU31 4.4 33.8 1.0 C A:LEU31 4.4 35.6 1.0 OG1 A:THR33 4.4 30.2 1.0 CG A:GLU72 4.6 23.7 1.0 N A:THR33 4.6 32.4 1.0 CA A:LEU31 4.7 35.9 1.0 O A:HOH479 4.9 51.5 1.0

Calcium binding site 4 out of 4 in the Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca603 b:42.8 occ:0.40 O A:HOH485 2.0 69.9 1.0 O A:THR33 2.2 26.1 1.0 OE1 A:GLU35 3.2 33.2 1.0 C A:THR33 3.5 26.1 1.0 OE2 A:GLU35 3.5 34.1 1.0 O A:HOH484 3.6 66.9 1.0 CD A:GLU35 3.8 29.2 1.0 N A:THR33 4.3 32.4 1.0 CA A:THR33 4.4 28.5 1.0 N A:ASP34 4.5 23.8 1.0 CA A:ASP34 4.7 18.8 1.0 CB A:THR33 4.8 26.0 1.0 N A:GLU35 4.9 16.5 1.0

A.Burger, D.Voges, P.Demange, C.R.Perez, R.Huber, R.Berendes. Structural and Electrophysiological Analysis of Annexin V Mutants. Mutagenesis of Human Annexin V, An in Vitro Voltage-Gated Calcium Channel, Provides Information About the Structural Features of the Ion Pathway, the Voltage Sensor and the Ion Selectivity Filter J.Mol.Biol. V. 237 479 1994.
ISSN: ISSN 0022-2836
PubMed: 8151707
DOI: 10.1006/JMBI.1994.1249