Calcium in PDB 1oxr: Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution

Enzymatic activity of Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution

All present enzymatic activity of Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution:
3.1.1.4;

Protein crystallography data

The structure of Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution, PDB code: 1oxr was solved by R.K.Singh, A.S.Ethayathulla, T.Jabeen, S.Sharma, P.Kaur, A.Srinivasan, T.P.Singh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.35 / 1.93
*Space group*	P 4₁
*Cell size a, b, c (Å), α, β, γ (°)*	42.627, 42.627, 65.137, 90.00, 90.00, 90.00
*R / R_free (%)*	17.5 / 20.4

Calcium Binding Sites:

The binding sites of Calcium atom in the Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution (pdb code 1oxr). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution, PDB code: 1oxr:

Calcium binding site 1 out of 1 in 1oxr

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Calcium Binding Sites List in 1oxr

Calcium binding site 1 out of 1 in the Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9A Resolution within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca201 b:3.4 occ:1.00	O	A:TYR28	2.5	20.2	1.0
	O	A:GLY30	2.5	28.6	1.0
	OD2	A:ASP49	2.5	28.0	1.0
	O	A:GLY32	2.5	33.6	1.0
	OD1	A:ASP49	2.7	21.0	1.0
	O	A:HOH232	2.8	53.0	1.0
	O1	A:AIN141	2.8	28.5	0.5
	CG	A:ASP49	3.0	21.1	1.0
	C	A:TYR28	3.6	19.8	1.0
	C	A:GLY30	3.6	28.4	1.0
	O2	A:AIN141	3.7	32.9	0.5
	C	A:GLY32	3.7	33.6	1.0
	C7	A:AIN141	3.7	32.1	0.5
	O	A:LYS31	4.0	34.1	1.0
	N	A:GLY30	4.0	24.7	1.0
	C	A:LYS31	4.1	33.1	1.0
	CA	A:TYR28	4.2	19.6	1.0
	O	A:HOH252	4.3	33.8	1.0
	CA	A:GLY30	4.4	26.7	1.0
	N	A:GLY32	4.4	33.8	1.0
	CA	A:GLY33	4.4	32.0	1.0
	CB	A:ASP49	4.5	16.3	1.0
	N	A:GLY33	4.5	32.7	1.0
	N	A:LYS31	4.6	30.8	1.0
	N	A:CYS29	4.6	19.6	1.0
	CA	A:GLY32	4.6	33.7	1.0
	C	A:CYS29	4.7	22.7	1.0
	CA	A:LYS31	4.8	32.7	1.0
	O	A:HOH298	4.8	46.9	1.0
	CA	A:CYS29	4.8	20.7	1.0
	CB	A:TYR28	4.8	19.6	1.0

Reference:

R.K.Singh, A.S.Ethayathulla, T.Jabeen, S.Sharma, P.Kaur, T.P.Singh. Aspirin Induces Its Anti-Inflammatory Effects Through Its Specific Binding to Phospholipase A2: Crystal Structure of the Complex Formed Between Phospholipase A2 and Aspirin at 1.9 Angstroms Resolution. J.Drug Target. V. 13 113 2005.
ISSN: ISSN 1061-186X
PubMed: 15823962
DOI: 10.1080/10611860400024078

Page generated: Thu Jul 11 13:36:54 2024

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