Calcium in PDB 1p6o: The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms.

Enzymatic activity of The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms.

All present enzymatic activity of The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms.:
3.5.4.1;

Protein crystallography data

The structure of The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms., PDB code: 1p6o was solved by G.C.Ireton, M.E.Black, B.L.Stoddard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	10.00 / 1.14
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	53.880, 70.417, 71.523, 90.00, 90.00, 90.00
*R / R_free (%)*	11 / 15.2

Other elements in 1p6o:

The structure of The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms. also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms. (pdb code 1p6o). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms., PDB code: 1p6o:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 1p6o

Go back to

Calcium Binding Sites List in 1p6o

Calcium binding site 1 out of 2 in the The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms.

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Ca402 b:10.7 occ:1.00	OE1	B:GLU328	2.3	16.8	1.0
	O	B:HOH1237	2.3	23.8	1.0
	O	B:HOH1016	2.4	11.1	1.0
	O	B:HOH1060	2.4	12.3	1.0
	CD	B:GLU328	3.4	14.0	1.0
	CG	B:GLU328	4.0	12.6	1.0
	OE2	B:GLU328	4.4	13.2	1.0
	O	B:HOH1101	4.5	18.7	1.0

Calcium binding site 2 out of 2 in 1p6o

Go back to

Calcium Binding Sites List in 1p6o

Calcium binding site 2 out of 2 in the The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms.

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of The Crystal Structure of Yeast Cytosine Deaminase Bound to 4(R)-Hydroxyl-3,4-Dihydropyrimidine at 1.14 Angstroms. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Ca403 b:21.1 occ:1.00	OE1	A:GLN150	2.3	21.2	1.0
	O	B:HOH1392	2.3	33.2	1.0
	O	B:HOH1312	2.3	32.8	1.0
	O	A:HOH1311	2.5	22.6	1.0
	OE1	B:GLU275	2.5	26.9	1.0
	O	A:HOH1231	2.5	19.3	1.0
	OE2	B:GLU275	2.7	28.3	1.0
	CD	B:GLU275	3.0	25.3	1.0
	CD	A:GLN150	3.4	21.5	1.0
	O	A:HOH1139	4.1	15.6	1.0
	CB	A:GLN150	4.2	16.7	1.0
	CG	A:GLN150	4.3	19.0	1.0
	O	B:HOH1114	4.3	17.4	1.0
	NE2	A:GLN150	4.4	28.6	1.0
	CG	B:GLU275	4.5	24.0	1.0
	O	B:HOH1368	4.5	42.6	1.0
	O	A:HOH1248	4.6	24.9	1.0
	O	A:GLU158	4.7	19.0	1.0
	O	A:GLN150	4.8	13.6	1.0
	CA	A:GLN150	4.9	15.2	1.0
	O	A:HOH1344	4.9	39.4	1.0

Reference:

G.C.Ireton, M.E.Black, B.L.Stoddard. The 1.14 A Crystal Structure of Yeast Cytosine Deaminase. Evolution of Nucleotide Salvage Enzymes and Implications For Genetic Chemotherapy. Structure V. 11 961 2003.
ISSN: ISSN 0969-2126
PubMed: 12906827
DOI: 10.1016/S0969-2126(03)00153-9

Page generated: Thu Jul 11 13:39:37 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy