Calcium in PDB 1pu4: Crystal Structure of Human Vascular Adhesion Protein-1
Enzymatic activity of Crystal Structure of Human Vascular Adhesion Protein-1
All present enzymatic activity of Crystal Structure of Human Vascular Adhesion Protein-1:
1.4.3.6;
Protein crystallography data
The structure of Crystal Structure of Human Vascular Adhesion Protein-1, PDB code: 1pu4
was solved by
T.A.Salminen,
T.T.Airenne,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
20.00 /
3.20
|
Space group
|
P 65 2 2
|
Cell size a, b, c (Å), α, β, γ (°)
|
225.916,
225.916,
218.668,
90.00,
90.00,
120.00
|
R / Rfree (%)
|
21.7 /
25.4
|
Other elements in 1pu4:
The structure of Crystal Structure of Human Vascular Adhesion Protein-1 also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Crystal Structure of Human Vascular Adhesion Protein-1
(pdb code 1pu4). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the
Crystal Structure of Human Vascular Adhesion Protein-1, PDB code: 1pu4:
Jump to Calcium binding site number:
1;
2;
3;
4;
Calcium binding site 1 out
of 4 in 1pu4
Go back to
Calcium Binding Sites List in 1pu4
Calcium binding site 1 out
of 4 in the Crystal Structure of Human Vascular Adhesion Protein-1
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Crystal Structure of Human Vascular Adhesion Protein-1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca802
b:24.5
occ:1.00
|
O
|
A:LEU530
|
2.3
|
24.1
|
1.0
|
OD1
|
A:ASP673
|
2.3
|
24.5
|
1.0
|
O
|
A:LEU674
|
2.3
|
24.6
|
1.0
|
OD1
|
A:ASP529
|
2.4
|
22.5
|
1.0
|
OD1
|
A:ASP531
|
2.4
|
25.6
|
1.0
|
C
|
A:LEU530
|
3.3
|
23.3
|
1.0
|
N
|
A:LEU674
|
3.4
|
25.9
|
1.0
|
C
|
A:LEU674
|
3.5
|
24.8
|
1.0
|
CG
|
A:ASP673
|
3.5
|
25.1
|
1.0
|
NZ
|
A:LYS106
|
3.6
|
16.9
|
1.0
|
CG
|
A:ASP529
|
3.6
|
21.4
|
1.0
|
CG
|
A:ASP531
|
3.7
|
25.6
|
1.0
|
N
|
A:ASP531
|
4.0
|
24.0
|
1.0
|
CA
|
A:LEU674
|
4.0
|
25.3
|
1.0
|
CA
|
A:ASP531
|
4.0
|
24.2
|
1.0
|
C
|
A:ASP673
|
4.1
|
26.4
|
1.0
|
OD2
|
A:ASP673
|
4.1
|
23.9
|
1.0
|
ND2
|
A:ASN537
|
4.1
|
23.2
|
1.0
|
N
|
A:LEU530
|
4.1
|
21.7
|
1.0
|
C
|
A:ASP529
|
4.2
|
20.9
|
1.0
|
CA
|
A:ASP673
|
4.3
|
26.6
|
1.0
|
CA
|
A:LEU530
|
4.3
|
22.4
|
1.0
|
OD2
|
A:ASP529
|
4.3
|
22.8
|
1.0
|
CB
|
A:ASP531
|
4.5
|
24.8
|
1.0
|
CB
|
A:ASP673
|
4.5
|
26.6
|
1.0
|
O
|
A:ASP529
|
4.5
|
20.3
|
1.0
|
CA
|
A:ASP529
|
4.5
|
20.8
|
1.0
|
OD2
|
A:ASP531
|
4.6
|
26.1
|
1.0
|
O
|
A:LEU535
|
4.6
|
29.8
|
1.0
|
N
|
A:VAL675
|
4.6
|
24.0
|
1.0
|
CB
|
A:ASP529
|
4.7
|
21.0
|
1.0
|
CB
|
A:LEU674
|
4.8
|
25.1
|
1.0
|
O
|
A:ASP673
|
4.9
|
26.2
|
1.0
|
|
Calcium binding site 2 out
of 4 in 1pu4
Go back to
Calcium Binding Sites List in 1pu4
Calcium binding site 2 out
of 4 in the Crystal Structure of Human Vascular Adhesion Protein-1
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Crystal Structure of Human Vascular Adhesion Protein-1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca803
b:37.6
occ:1.00
|
OE1
|
A:GLU667
|
2.3
|
37.9
|
1.0
|
O
|
A:PHE663
|
2.3
|
33.5
|
1.0
|
OD1
|
A:ASN665
|
2.4
|
38.8
|
1.0
|
NZ
|
A:LYS638
|
2.8
|
25.0
|
1.0
|
OE2
|
A:GLU572
|
3.0
|
28.7
|
1.0
|
OE1
|
A:GLU572
|
3.0
|
28.6
|
1.0
|
CG
|
A:ASN665
|
3.4
|
37.1
|
1.0
|
CD
|
A:GLU572
|
3.4
|
30.1
|
1.0
|
C
|
A:PHE663
|
3.4
|
32.0
|
1.0
|
CD
|
A:GLU667
|
3.5
|
37.7
|
1.0
|
OE2
|
A:GLU641
|
3.5
|
26.8
|
1.0
|
ND2
|
A:ASN665
|
3.9
|
37.0
|
1.0
|
OE1
|
A:GLU641
|
4.0
|
30.0
|
1.0
|
CA
|
A:PHE663
|
4.1
|
31.4
|
1.0
|
CD
|
A:GLU641
|
4.2
|
27.9
|
1.0
|
OE2
|
A:GLU667
|
4.2
|
38.0
|
1.0
|
CE
|
A:LYS638
|
4.2
|
25.6
|
1.0
|
CG
|
A:GLU667
|
4.5
|
36.6
|
1.0
|
O
|
A:GLN636
|
4.5
|
26.8
|
1.0
|
N
|
A:ASN665
|
4.5
|
34.9
|
1.0
|
CB
|
A:ASN665
|
4.5
|
35.9
|
1.0
|
N
|
A:ILE664
|
4.6
|
32.8
|
1.0
|
CG2
|
A:THR635
|
4.6
|
27.2
|
1.0
|
CB
|
A:GLN636
|
4.6
|
27.0
|
1.0
|
CB
|
A:PHE663
|
4.7
|
31.4
|
1.0
|
CD
|
A:LYS638
|
4.7
|
26.9
|
1.0
|
N
|
A:GLN636
|
4.7
|
27.0
|
1.0
|
OG1
|
A:THR635
|
4.8
|
26.4
|
1.0
|
CA
|
A:ILE664
|
4.9
|
33.2
|
1.0
|
CG
|
A:GLU572
|
4.9
|
30.6
|
1.0
|
|
Calcium binding site 3 out
of 4 in 1pu4
Go back to
Calcium Binding Sites List in 1pu4
Calcium binding site 3 out
of 4 in the Crystal Structure of Human Vascular Adhesion Protein-1
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Crystal Structure of Human Vascular Adhesion Protein-1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca802
b:23.8
occ:1.00
|
O
|
B:LEU530
|
2.3
|
24.3
|
1.0
|
O
|
B:LEU674
|
2.3
|
25.0
|
1.0
|
OD1
|
B:ASP673
|
2.3
|
24.2
|
1.0
|
OD1
|
B:ASP529
|
2.3
|
21.8
|
1.0
|
OD1
|
B:ASP531
|
2.4
|
25.6
|
1.0
|
C
|
B:LEU530
|
3.4
|
23.6
|
1.0
|
N
|
B:LEU674
|
3.4
|
26.1
|
1.0
|
C
|
B:LEU674
|
3.4
|
25.0
|
1.0
|
CG
|
B:ASP673
|
3.5
|
25.2
|
1.0
|
CG
|
B:ASP529
|
3.6
|
21.0
|
1.0
|
CG
|
B:ASP531
|
3.6
|
24.9
|
1.0
|
NZ
|
B:LYS106
|
3.6
|
18.4
|
1.0
|
ND2
|
B:ASN537
|
3.6
|
24.6
|
1.0
|
C
|
B:ASP673
|
4.0
|
26.5
|
1.0
|
CA
|
B:LEU674
|
4.0
|
25.5
|
1.0
|
N
|
B:ASP531
|
4.1
|
24.2
|
1.0
|
CA
|
B:ASP531
|
4.1
|
24.2
|
1.0
|
OD2
|
B:ASP529
|
4.2
|
20.1
|
1.0
|
CA
|
B:ASP673
|
4.2
|
26.7
|
1.0
|
N
|
B:LEU530
|
4.3
|
21.9
|
1.0
|
C
|
B:ASP529
|
4.3
|
21.2
|
1.0
|
OD2
|
B:ASP673
|
4.3
|
24.5
|
1.0
|
CB
|
B:ASP531
|
4.5
|
24.6
|
1.0
|
CA
|
B:LEU530
|
4.5
|
22.7
|
1.0
|
OD2
|
B:ASP531
|
4.5
|
24.0
|
1.0
|
CB
|
B:ASP673
|
4.5
|
26.6
|
1.0
|
CA
|
B:ASP529
|
4.6
|
20.9
|
1.0
|
O
|
B:ASP529
|
4.6
|
20.7
|
1.0
|
N
|
B:VAL675
|
4.6
|
24.2
|
1.0
|
O
|
B:LEU535
|
4.6
|
29.8
|
1.0
|
CB
|
B:ASP529
|
4.7
|
20.9
|
1.0
|
O
|
B:ASP673
|
4.7
|
26.4
|
1.0
|
CB
|
B:LEU674
|
4.8
|
25.6
|
1.0
|
CG
|
B:ASN537
|
5.0
|
26.2
|
1.0
|
|
Calcium binding site 4 out
of 4 in 1pu4
Go back to
Calcium Binding Sites List in 1pu4
Calcium binding site 4 out
of 4 in the Crystal Structure of Human Vascular Adhesion Protein-1
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Crystal Structure of Human Vascular Adhesion Protein-1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca803
b:37.7
occ:1.00
|
OE1
|
B:GLU667
|
2.3
|
38.3
|
1.0
|
O
|
B:PHE663
|
2.3
|
33.7
|
1.0
|
OD1
|
B:ASN665
|
2.4
|
38.1
|
1.0
|
OE2
|
B:GLU572
|
3.0
|
28.1
|
1.0
|
OE1
|
B:GLU572
|
3.0
|
26.6
|
1.0
|
NZ
|
B:LYS638
|
3.3
|
27.1
|
1.0
|
CD
|
B:GLU667
|
3.4
|
37.0
|
1.0
|
CG
|
B:ASN665
|
3.4
|
36.7
|
1.0
|
CD
|
B:GLU572
|
3.4
|
29.8
|
1.0
|
C
|
B:PHE663
|
3.5
|
32.1
|
1.0
|
OE2
|
B:GLU641
|
3.6
|
26.6
|
1.0
|
OE1
|
B:GLU641
|
3.8
|
29.3
|
1.0
|
ND2
|
B:ASN665
|
3.8
|
37.1
|
1.0
|
CA
|
B:PHE663
|
4.0
|
31.5
|
1.0
|
CD
|
B:GLU641
|
4.1
|
27.3
|
1.0
|
CD
|
B:LYS638
|
4.1
|
27.6
|
1.0
|
OE2
|
B:GLU667
|
4.1
|
36.1
|
1.0
|
O
|
B:GLN636
|
4.2
|
26.7
|
1.0
|
CE
|
B:LYS638
|
4.2
|
27.2
|
1.0
|
CG
|
B:GLU667
|
4.2
|
36.2
|
1.0
|
OG1
|
B:THR635
|
4.4
|
26.0
|
1.0
|
CG2
|
B:THR635
|
4.5
|
26.9
|
1.0
|
CB
|
B:PHE663
|
4.5
|
31.5
|
1.0
|
N
|
B:GLN636
|
4.6
|
26.9
|
1.0
|
CB
|
B:GLN636
|
4.6
|
27.0
|
1.0
|
N
|
B:ILE664
|
4.6
|
32.8
|
1.0
|
CB
|
B:ASN665
|
4.7
|
35.7
|
1.0
|
N
|
B:ASN665
|
4.7
|
34.9
|
1.0
|
CG
|
B:GLU572
|
4.9
|
31.2
|
1.0
|
CA
|
B:ILE664
|
5.0
|
33.4
|
1.0
|
CA
|
B:GLN636
|
5.0
|
26.7
|
1.0
|
|
Reference:
T.T.Airenne,
Y.Nymalm,
H.Kidron,
D.J.Smith,
M.Pihlavisto,
M.Salmi,
S.Jalkanen,
M.S.Johnson,
T.A.Salminen.
Crystal Structure of the Human Vascular Adhesion Protein-1: Unique Structural Features with Functional Implications. Protein Sci. V. 14 1964 2005.
ISSN: ISSN 0961-8368
PubMed: 16046623
DOI: 10.1110/PS.051438105
Page generated: Thu Jul 11 13:53:13 2024
|