Calcium in PDB 1tx7: Bovine Trypsin Complexed with P-Amidinophenylmethylphosphinic Acid (Ampa)

All present enzymatic activity of Bovine Trypsin Complexed with P-Amidinophenylmethylphosphinic Acid (Ampa):
3.4.21.4;

The structure of Bovine Trypsin Complexed with P-Amidinophenylmethylphosphinic Acid (Ampa), PDB code: 1tx7 was solved by J.Cui, F.Marankan, W.Fu, D.Crich, A.Mesecar, M.E.Johnson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.75
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	54.870, 58.440, 67.520, 90.00, 90.00, 90.00
R / Rfree (%)	18.3 / 22.9

The binding sites of Calcium atom in the Bovine Trypsin Complexed with P-Amidinophenylmethylphosphinic Acid (Ampa) (pdb code 1tx7). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Bovine Trypsin Complexed with P-Amidinophenylmethylphosphinic Acid (Ampa), PDB code: 1tx7:

Calcium binding site 1 out of 1 in the Bovine Trypsin Complexed with P-Amidinophenylmethylphosphinic Acid (Ampa)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Bovine Trypsin Complexed with P-Amidinophenylmethylphosphinic Acid (Ampa) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca246 b:11.2 occ:1.00 O A:VAL75 2.3 11.4 1.0 OE1 A:GLU70 2.3 8.5 1.0 O A:ASN72 2.4 10.6 1.0 O A:HOH274 2.5 9.7 1.0 O A:HOH255 2.5 8.6 1.0 OE2 A:GLU80 2.5 14.3 1.0 CD A:GLU70 3.4 8.0 1.0 C A:VAL75 3.4 12.1 1.0 CD A:GLU80 3.5 12.4 1.0 C A:ASN72 3.5 9.6 1.0 OE2 A:GLU70 3.8 9.5 1.0 CG A:GLU80 3.8 12.7 1.0 CA A:VAL76 4.1 12.8 1.0 OE1 A:GLU77 4.2 15.0 1.0 N A:VAL76 4.2 13.4 1.0 N A:GLU77 4.2 12.4 1.0 N A:VAL75 4.2 10.6 1.0 CA A:ILE73 4.3 9.8 1.0 O A:HOH327 4.3 15.0 1.0 N A:ILE73 4.3 8.5 1.0 N A:ASN72 4.4 9.0 1.0 CA A:VAL75 4.4 10.9 1.0 CG A:GLU77 4.5 15.7 1.0 CA A:ASN72 4.5 8.4 1.0 C A:ILE73 4.6 9.4 1.0 OE1 A:GLU80 4.6 10.5 1.0 O A:HOH295 4.6 33.8 1.0 N A:ASP71 4.6 8.7 1.0 C A:VAL76 4.6 13.5 1.0 CG A:GLU70 4.7 8.8 1.0 CA A:GLU70 4.8 9.5 1.0 CD A:GLU77 4.8 17.8 1.0 CB A:ASN72 4.8 6.5 1.0 CB A:GLU77 4.8 14.8 1.0 CB A:GLU70 4.9 7.0 1.0 N A:ASN74 4.9 6.8 1.0 O A:ILE73 5.0 10.9 1.0

J.Cui, F.Marankan, W.Fu, D.Crich, A.Mesecar, M.E.Johnson. An Oxyanion-Hole Selective Serine Protease Inhibitor in Complex with Trypsin. Bioorg.Med.Chem. V. 10 41 2002.
ISSN: ISSN 0968-0896
PubMed: 11738605
DOI: 10.1016/S0968-0896(01)00259-0