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Atomistry » Calcium » PDB 1v3e-1vfm » 1v3x | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Calcium » PDB 1v3e-1vfm » 1v3x » |
Calcium in PDB 1v3x: Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)PiperazineEnzymatic activity of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine
All present enzymatic activity of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine, PDB code: 1v3x
was solved by
M.Suzuki,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1v3x:
The structure of Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine
(pdb code 1v3x). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine, PDB code: 1v3x: Jump to Calcium binding site number: 1; 2; Calcium binding site 1 out of 2 in 1v3xGo back to Calcium Binding Sites List in 1v3x
Calcium binding site 1 out
of 2 in the Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine
Mono view Stereo pair view
Calcium binding site 2 out of 2 in 1v3xGo back to Calcium Binding Sites List in 1v3x
Calcium binding site 2 out
of 2 in the Factor Xa in Complex with the Inhibitor 1-[6-Methyl-4,5,6,7- Tetrahydrothiazolo(5,4-C)Pyridin-2-Yl] Carbonyl-2- Carbamoyl-4-(6-Chloronaphth-2-Ylsulphonyl)Piperazine
Mono view Stereo pair view
Reference:
N.Haginoya,
S.Kobayashi,
S.Komoriya,
T.Yoshino,
M.Suzuki,
T.Shimada,
K.Watanabe,
Y.Hirokawa,
T.Furugori,
T.Nagahara.
Synthesis and Conformational Analysis of A Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine As S4 Binding Element J.Med.Chem. V. 47 5167 2004.
Page generated: Thu Jul 11 23:53:55 2024
ISSN: ISSN 0022-2623 PubMed: 15456260 DOI: 10.1021/JM049884D |
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