Calcium in PDB 1xjl: Structure of Human Annexin A2 in the Presence of Calcium Ions

The structure of Structure of Human Annexin A2 in the Presence of Calcium Ions, PDB code: 1xjl was solved by A.Rosengarth, H.Luecke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.06 / 2.59
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	61.781, 98.105, 176.273, 90.00, 90.00, 90.00
R / Rfree (%)	21.6 / 26.4

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 14;

Binding sites:

The binding sites of Calcium atom in the Structure of Human Annexin A2 in the Presence of Calcium Ions (pdb code 1xjl). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 14 binding sites of Calcium where determined in the Structure of Human Annexin A2 in the Presence of Calcium Ions, PDB code: 1xjl:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Calcium binding site 1 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca340 b:51.7 occ:1.00 OE2 A:GLU53 2.2 55.1 1.0 O A:HOH439 2.3 46.4 1.0 O A:HOH349 2.3 36.8 1.0 O A:GLY50 2.5 59.4 1.0 O A:HOH350 2.5 53.5 1.0 O A:VAL51 2.8 57.1 1.0 CD A:GLU53 2.9 53.5 1.0 OE1 A:GLU53 2.9 54.4 1.0 C A:GLY50 3.5 60.1 1.0 C A:VAL51 3.9 58.3 1.0 CB A:VAL51 4.3 59.7 1.0 CG A:GLU53 4.3 51.4 1.0 N A:VAL51 4.3 59.5 1.0 CA A:VAL51 4.4 59.0 1.0 CA A:GLY50 4.5 60.8 1.0 CG1 A:VAL51 5.0 59.6 1.0

Calcium binding site 2 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca341 b:50.9 occ:1.00 OE1 A:GLU96 2.4 47.9 1.0 O A:LYS88 2.4 43.9 1.0 O A:LEU91 2.4 41.1 1.0 O A:HOH351 2.5 49.2 1.0 CD A:GLU96 3.5 47.0 1.0 C A:LEU91 3.6 42.3 1.0 C A:LYS88 3.6 45.4 1.0 CA A:SER92 4.0 42.1 1.0 OE2 A:GLU96 4.1 49.5 1.0 N A:SER92 4.2 42.4 1.0 CB A:SER92 4.3 41.3 1.0 O A:SER89 4.4 48.1 1.0 CA A:SER89 4.4 47.3 1.0 N A:SER89 4.5 45.0 1.0 CG A:LYS88 4.5 52.5 1.0 CG A:GLU96 4.5 44.1 1.0 C A:SER89 4.6 47.1 1.0 CA A:LYS88 4.6 46.2 1.0 N A:LEU91 4.7 44.4 1.0 CA A:LEU91 4.8 43.0 1.0

Calcium binding site 3 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca342 b:60.8 occ:1.00 OD2 A:ASP162 2.2 59.4 1.0 O A:MET118 2.4 52.0 1.0 O A:GLY122 2.5 58.5 1.0 O A:GLY120 2.7 62.6 1.0 CG A:ASP162 2.9 60.2 1.0 OD1 A:ASP162 3.2 61.1 1.0 C A:MET118 3.6 53.9 1.0 C A:GLY122 3.6 59.7 1.0 N A:GLY122 3.8 62.6 1.0 C A:GLY120 3.8 62.7 1.0 OG1 A:THR123 3.8 57.6 1.0 CB A:ASP162 4.2 58.5 1.0 O A:HOH378 4.2 23.7 1.0 CA A:MET118 4.2 51.7 1.0 C A:LEU121 4.2 63.5 1.0 CA A:GLY122 4.3 61.0 1.0 CA A:LEU121 4.4 64.1 1.0 C A:LYS119 4.5 61.6 1.0 N A:GLY120 4.5 61.5 1.0 N A:LEU121 4.6 63.3 1.0 N A:THR123 4.6 58.5 1.0 N A:LYS119 4.6 57.5 1.0 CA A:ASP162 4.7 56.6 1.0 O A:LYS119 4.7 60.9 1.0 CB A:MET118 4.7 50.0 1.0 CA A:GLY120 4.8 62.2 1.0 CA A:THR123 4.9 56.5 1.0 CA A:LYS119 4.9 60.9 1.0 CB A:THR123 4.9 57.1 1.0 O A:LEU121 5.0 63.3 1.0

Calcium binding site 4 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca343 b:52.4 occ:1.00 O A:HOH437 2.2 44.2 1.0 O A:GLY207 2.3 51.5 1.0 O A:ARG205 2.3 54.1 1.0 OE1 A:GLU247 2.6 45.6 1.0 O A:HOH352 2.7 33.9 1.0 OE2 A:GLU247 2.8 43.4 1.0 O A:GLY202 2.9 45.0 1.0 CD A:GLU247 3.0 45.5 1.0 C A:GLY207 3.3 51.6 1.0 N A:GLY207 3.4 53.4 1.0 C A:ARG205 3.5 55.5 1.0 C A:GLY202 3.8 43.8 1.0 CA A:GLY207 3.8 52.1 1.0 C A:LYS206 3.9 54.7 1.0 OG1 A:THR208 4.1 52.4 1.0 CA A:LYS206 4.2 57.3 1.0 O A:HOH353 4.3 51.2 1.0 N A:LYS206 4.3 57.0 1.0 N A:THR208 4.5 50.0 1.0 N A:VAL203 4.5 45.4 1.0 CG A:GLU247 4.5 46.6 1.0 CA A:VAL203 4.5 48.0 1.0 O A:LYS206 4.6 54.8 1.0 O A:VAL203 4.6 49.9 1.0 CA A:ARG205 4.6 55.4 1.0 CA A:GLY202 4.6 43.2 1.0 N A:ARG205 4.7 54.6 1.0 C A:VAL203 4.7 50.1 1.0 CA A:THR208 4.9 48.2 1.0 CG A:ARG205 5.0 55.1 1.0

Calcium binding site 5 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca344 b:58.3 occ:1.00 O A:VAL248 2.4 46.5 1.0 O A:HOH347 2.4 48.7 1.0 OE2 A:GLU253 2.5 48.6 1.0 O A:ARG245 2.7 48.3 1.0 O A:HOH348 3.2 41.2 1.0 CD A:GLU253 3.4 48.0 1.0 C A:ARG245 3.5 46.6 1.0 C A:VAL248 3.5 46.6 1.0 CA A:LYS249 3.9 49.6 1.0 OE1 A:GLU253 3.9 49.5 1.0 CB A:LYS249 4.0 52.4 1.0 CA A:ARG245 4.1 45.1 1.0 N A:LYS249 4.2 47.2 1.0 CG A:GLU253 4.4 46.5 1.0 O A:HOH438 4.4 40.4 1.0 N A:LYS246 4.4 47.1 1.0 O A:ILE244 4.6 44.3 1.0 N A:VAL248 4.7 45.5 1.0 CA A:LYS246 4.7 48.7 1.0 CA A:VAL248 4.7 45.9 1.0 O A:HOH434 4.8 46.1 1.0 C A:LYS246 4.9 48.5 1.0 CB A:GLU253 4.9 44.1 1.0 CB A:ARG245 5.0 42.3 1.0

Calcium binding site 6 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca345 b:30.7 occ:1.00 O A:GLY280 2.2 36.1 1.0 O A:HOH354 2.2 22.7 1.0 O A:GLY282 2.4 34.0 1.0 O A:MET278 2.4 30.4 1.0 OD1 A:ASP322 2.5 24.8 1.0 OD2 A:ASP322 2.5 28.9 1.0 CG A:ASP322 2.8 30.3 1.0 C A:MET278 3.3 30.4 1.0 C A:GLY280 3.4 34.8 1.0 C A:GLY282 3.6 32.4 1.0 CA A:MET278 3.8 29.4 1.0 N A:GLY282 4.0 32.8 1.0 N A:GLY280 4.0 33.4 1.0 C A:LYS281 4.1 33.2 1.0 OG1 A:THR283 4.2 32.5 1.0 O A:HOH431 4.2 38.5 1.0 CA A:GLY280 4.3 33.1 1.0 CA A:GLY282 4.3 32.3 1.0 CB A:ASP322 4.3 32.8 1.0 C A:LYS279 4.4 33.3 1.0 O A:LYS281 4.4 33.1 1.0 N A:LYS281 4.4 34.7 1.0 CB A:MET278 4.4 28.3 1.0 N A:LYS279 4.4 30.8 1.0 CA A:LYS281 4.5 34.2 1.0 N A:THR283 4.6 31.8 1.0 CA A:THR283 4.8 31.9 1.0 O A:LYS279 4.8 33.9 1.0 CA A:LYS279 4.9 31.6 1.0 O A:HOH358 4.9 29.4 1.0 O A:SER277 5.0 28.0 1.0

Calcium binding site 7 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca346 b:56.6 occ:1.00 O A:HOH443 2.3 43.9 1.0 O A:THR123 2.4 55.0 1.0 O A:HOH444 2.4 25.4 1.0 OE1 A:GLU125 2.4 55.9 1.0 O A:HOH445 2.6 27.9 1.0 OE2 A:GLU125 2.7 54.5 1.0 CD A:GLU125 2.9 55.2 1.0 C A:THR123 3.4 54.6 1.0 N A:THR123 3.9 58.5 1.0 CA A:THR123 4.2 56.5 1.0 N A:ASP124 4.3 52.3 1.0 CG A:GLU125 4.4 53.1 1.0 N A:GLU125 4.4 47.7 1.0 CA A:ASP124 4.5 49.6 1.0 O A:HOH413 4.9 36.7 1.0 CB A:THR123 5.0 57.1 1.0 C A:GLY122 5.0 59.7 1.0

Calcium binding site 8 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca340 b:61.5 occ:1.00 O B:HOH352 2.3 51.1 1.0 O B:GLY50 2.3 61.9 1.0 O B:HOH347 2.3 34.3 1.0 OE1 B:GLU53 2.5 51.0 1.0 OE2 B:GLU53 2.6 49.0 1.0 CD B:GLU53 2.9 51.2 1.0 O B:VAL51 2.9 56.3 1.0 C B:GLY50 3.3 62.6 1.0 C B:VAL51 3.9 56.6 1.0 CA B:GLY50 4.1 64.2 1.0 N B:VAL51 4.2 60.3 1.0 CG B:GLU53 4.4 50.0 1.0 CA B:VAL51 4.4 57.4 1.0 CB B:VAL51 4.5 55.4 1.0 N B:GLU53 4.9 53.5 1.0

Calcium binding site 9 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 9 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca341 b:58.2 occ:1.00 O B:LYS88 2.3 54.8 1.0 OE1 B:GLU96 2.4 50.2 1.0 O B:LEU91 2.5 43.5 1.0 O B:HOH349 2.7 45.6 1.0 O B:HOH348 2.7 38.3 1.0 CD B:GLU96 3.5 49.9 1.0 C B:LYS88 3.6 53.8 1.0 C B:LEU91 3.6 45.3 1.0 OE2 B:GLU96 3.9 49.6 1.0 NZ B:LYS88 4.0 60.9 1.0 O B:SER89 4.2 55.4 1.0 CA B:SER92 4.2 48.5 1.0 CA B:SER89 4.3 55.1 1.0 CG B:LYS88 4.3 53.9 1.0 N B:SER92 4.4 46.8 1.0 N B:SER89 4.4 54.4 1.0 CB B:SER92 4.4 48.5 1.0 C B:SER89 4.5 54.0 1.0 CA B:LYS88 4.6 52.8 1.0 CG B:GLU96 4.7 46.5 1.0 CA B:LEU91 4.7 45.7 1.0 N B:LEU91 4.7 48.7 1.0

Calcium binding site 10 out of 14 in the Structure of Human Annexin A2 in the Presence of Calcium Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 10 of Structure of Human Annexin A2 in the Presence of Calcium Ions within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca342 b:47.8 occ:1.00 OD2 B:ASP162 2.2 46.1 1.0 O B:GLY120 2.3 50.4 1.0 O B:GLY122 2.4 49.5 1.0 O B:MET118 2.4 45.7 1.0 OD1 B:ASP162 2.5 44.2 1.0 CG B:ASP162 2.7 43.8 1.0 O B:HOH353 2.9 33.2 1.0 C B:GLY122 3.5 50.5 1.0 C B:MET118 3.5 46.7 1.0 C B:GLY120 3.6 51.7 1.0 N B:GLY122 3.8 51.7 1.0 C B:LEU121 4.2 52.9 1.0 CB B:ASP162 4.2 41.5 1.0 CA B:GLY122 4.2 51.1 1.0 CA B:MET118 4.2 43.9 1.0 N B:GLY120 4.3 51.2 1.0 C B:LYS119 4.3 51.8 1.0 OG1 B:THR123 4.4 48.6 1.0 CA B:GLY120 4.5 51.2 1.0 N B:LEU121 4.5 52.8 1.0 CA B:LEU121 4.5 53.5 1.0 O B:LYS119 4.5 51.0 1.0 N B:THR123 4.5 49.2 1.0 N B:LYS119 4.6 50.2 1.0 CB B:MET118 4.7 40.0 1.0 O B:LEU121 4.8 53.1 1.0 CA B:THR123 4.8 46.8 1.0 CA B:LYS119 4.9 52.2 1.0 CA B:ASP162 4.9 40.7 1.0

A.Rosengarth, H.Luecke. Annexin A2: Does It Induce Membrane Aggregation By A New Multimeric State of the Protein? Annexins V. 1 129 2004.
ISSN: ISSN 1547-6294