Calcium in PDB 2a30: Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine

All present enzymatic activity of Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine:
2.7.1.74;

The structure of Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine, PDB code: 2a30 was solved by M.H.Godsey, S.Ort, E.Sabini, M.Konrad, A.Lavie, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.90 / 3.02
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	79.337, 64.941, 108.602, 90.00, 95.97, 90.00
R / Rfree (%)	23.5 / 28.5

The binding sites of Calcium atom in the Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine (pdb code 2a30). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine, PDB code: 2a30:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca261 b:76.0 occ:1.00 OD1 A:ASN60 2.5 75.0 1.0 CG A:ASN60 3.7 72.7 1.0 ND2 A:ASN60 4.4 71.6 1.0 O A:CYS59 4.7 65.0 1.0 CB A:ASN60 4.8 73.5 1.0 CA A:SER63 4.9 81.9 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Human Deoxycytidine Kinase in Complex with Deoxycytidine within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca261 b:76.8 occ:1.00 OD1 C:ASN60 2.6 74.8 1.0 CG C:ASN60 3.9 72.3 1.0 CA C:SER63 4.2 83.0 1.0 ND2 C:ASN60 4.7 72.1 1.0 CB C:ASN60 4.8 72.2 1.0 C C:SER63 4.9 82.7 1.0 CB C:SER63 4.9 82.5 1.0

M.H.Godsey, S.Ort, E.Sabini, M.Konrad, A.Lavie. Structural Basis For the Preference of Utp Over Atp in Human Deoxycytidine Kinase: Illuminating the Role of Main-Chain Reorganization. Biochemistry V. 45 452 2006.
ISSN: ISSN 0006-2960
PubMed: 16401075
DOI: 10.1021/BI0518646