Atomistry » Calcium » PDB 2a30-2agp » 2aei
Atomistry »
  Calcium »
    PDB 2a30-2agp »
      2aei »

Calcium in PDB 2aei: Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid

Enzymatic activity of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid

All present enzymatic activity of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid:
3.4.21.21;

Protein crystallography data

The structure of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid, PDB code: 2aei was solved by M.Adler, M.Whitlow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.52
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 70.215, 80.496, 125.936, 90.00, 90.00, 90.00
R / Rfree (%) 19.9 / 29.7

Other elements in 2aei:

The structure of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Arsenic (As) 1 atom

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid (pdb code 2aei). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid, PDB code: 2aei:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 1 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Ca501

b:72.1
occ:1.00
 OE12 L:CGU29 1.7 57.6 1.0
OE12 L:CGU25 1.7 66.7 1.0
OE21 L:CGU25 1.8 67.4 1.0
CD1 L:CGU25 2.6 61.4 1.0
CD1 L:CGU29 2.6 53.5 1.0
CD2 L:CGU25 2.6 63.5 1.0
CG L:CGU25 2.9 58.5 1.0
OE11 L:CGU29 3.1 57.7 1.0
OE22 L:CGU29 3.5 39.7 1.0
OE11 L:CGU25 3.7 61.0 1.0
OE22 L:CGU25 3.8 63.7 1.0
CG L:CGU29 3.8 48.5 1.0
NH2 L:ARG28 4.1 65.0 1.0
CD2 L:CGU29 4.1 46.9 1.0
CA L:CA502 4.3 79.2 1.0
CB L:CGU25 4.4 52.4 1.0
CB L:CGU29 4.5 48.8 1.0
O L:CGU25 4.9 43.7 1.0

Calcium binding site 2 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 2 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Ca502

b:79.2
occ:1.00
 OE12 L:CGU7 1.7 57.0 1.0
OE11 L:CGU26 1.7 57.9 1.0
OE22 L:CGU29 1.7 39.7 1.0
CD1 L:CGU7 2.3 56.1 1.0
CD2 L:CGU29 2.8 46.9 1.0
OE11 L:CGU7 2.8 53.5 1.0
CD1 L:CGU26 2.9 56.9 1.0
OE21 L:CGU29 3.2 49.4 1.0
OE21 L:CGU7 3.3 55.5 1.0
OE21 L:CGU25 3.3 67.4 1.0
CD2 L:CGU7 3.3 56.2 1.0
CG L:CGU7 3.4 54.8 1.0
OE12 L:CGU26 3.5 64.7 1.0
CD2 L:CGU25 3.8 63.5 1.0
OE12 L:CGU29 3.8 57.6 1.0
ND2 L:ASN2 3.8 32.8 1.0
CG L:CGU26 4.0 49.8 1.0
OE22 L:CGU7 4.0 55.6 1.0
CA L:CA503 4.1 54.0 1.0
CG L:CGU29 4.1 48.5 1.0
OE22 L:CGU25 4.2 63.7 1.0
OD1 L:ASN2 4.3 33.6 1.0
CA L:CA501 4.3 72.1 1.0
CG L:ASN2 4.4 31.9 1.0
CD1 L:CGU29 4.4 53.5 1.0
CB L:CGU7 4.5 54.3 1.0
CG L:CGU25 4.5 58.5 1.0
CA L:CGU26 4.8 41.8 1.0

Calcium binding site 3 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 3 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Ca503

b:54.0
occ:1.00
 OE21 L:CGU29 1.8 49.4 1.0
OE21 L:CGU7 1.8 55.5 1.0
OE22 L:CGU7 1.9 55.6 1.0
OE12 L:CGU16 1.9 38.6 1.0
CD2 L:CGU7 2.2 56.2 1.0
CD1 L:CGU16 2.9 38.7 1.0
CD2 L:CGU29 3.0 46.9 1.0
OE11 L:CGU16 3.1 41.8 1.0
CA L:CA504 3.5 38.7 1.0
CG L:CGU26 3.6 49.8 1.0
OE11 L:CGU26 3.6 57.9 1.0
OE22 L:CGU29 3.7 39.7 1.0
CG L:CGU7 3.7 54.8 1.0
OE11 L:CGU6 3.9 66.1 1.0
OE21 L:CGU26 4.0 50.9 1.0
CD1 L:CGU26 4.1 56.9 1.0
CA L:CA502 4.1 79.2 1.0
CG L:CGU29 4.2 48.5 1.0
CG L:CGU16 4.3 39.4 1.0
CD2 L:CGU26 4.3 48.1 1.0
OE21 L:CGU16 4.4 38.5 1.0
OE12 L:CGU7 4.4 57.0 1.0
CB L:CGU26 4.4 42.4 1.0
CA L:GLY11 4.4 45.4 1.0
CD1 L:CGU7 4.4 56.1 1.0
OE12 L:CGU6 4.5 63.0 1.0
OD1 L:ASN2 4.5 33.6 1.0
CA L:CGU26 4.6 41.8 1.0
CB L:CGU29 4.6 48.8 1.0
O L:CGU26 4.6 43.6 1.0
CB L:CGU7 4.6 54.3 1.0
CD1 L:CGU6 4.6 66.2 1.0
CD2 L:CGU16 4.8 44.0 1.0
N L:GLY11 4.8 46.0 1.0
CA L:CGU7 4.9 54.1 1.0

Calcium binding site 4 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 4 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Ca504

b:38.7
occ:1.00
 OE21 L:CGU26 1.7 50.9 1.0
OE11 L:CGU6 1.7 66.1 1.0
OE21 L:CGU16 1.8 38.5 1.0
OD1 L:ASN2 2.3 33.6 1.0
OE12 L:CGU16 2.4 38.6 1.0
OE21 L:CGU7 2.4 55.5 1.0
O L:ALA1 2.6 38.6 1.0
CD1 L:CGU6 2.7 66.2 1.0
CD2 L:CGU26 2.9 48.1 1.0
CD2 L:CGU16 2.9 44.0 1.0
CD1 L:CGU16 3.3 38.7 1.0
OE12 L:CGU6 3.3 63.0 1.0
CD2 L:CGU7 3.3 56.2 1.0
CA L:CA503 3.5 54.0 1.0
CG L:CGU26 3.5 49.8 1.0
CG L:ASN2 3.5 31.9 1.0
C L:ALA1 3.6 38.8 1.0
CG L:CGU16 3.6 39.4 1.0
CA L:CA505 3.7 0.2 1.0
CG L:CGU6 3.8 65.8 1.0
OE22 L:CGU16 3.8 50.3 1.0
OE22 L:CGU26 3.9 46.3 1.0
CD2 L:CGU6 4.0 70.7 1.0
CA L:ASN2 4.0 37.0 1.0
CG L:CGU7 4.1 54.8 1.0
OE22 L:CGU7 4.1 55.6 1.0
OE11 L:CGU26 4.2 57.9 1.0
N L:ASN2 4.2 38.5 1.0
CD1 L:CGU26 4.2 56.9 1.0
OE21 L:CGU6 4.3 73.2 1.0
N L:ALA1 4.3 38.3 1.0
CB L:ASN2 4.4 31.0 1.0
OE22 L:CGU6 4.4 74.5 1.0
OE11 L:CGU16 4.4 41.8 1.0
ND2 L:ASN2 4.5 32.8 1.0
CB L:CGU16 4.5 38.3 1.0
CA L:ALA1 4.6 38.1 1.0
CB L:CGU26 4.8 42.4 1.0
OE21 L:CGU29 4.9 49.4 1.0
CD1 L:CGU7 4.9 56.1 1.0

Calcium binding site 5 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 5 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Ca505

b:0.2
occ:1.00
 OE22 L:CGU6 1.7 74.5 1.0
OE21 L:CGU20 1.7 67.1 1.0
OE22 L:CGU16 1.7 50.3 1.0
OE21 L:CGU16 2.3 38.5 1.0
CD2 L:CGU16 2.3 44.0 1.0
CD2 L:CGU6 2.3 70.7 1.0
OE21 L:CGU6 2.7 73.2 1.0
O L:ALA1 2.9 38.6 1.0
CD2 L:CGU20 2.9 66.1 1.0
CD1 L:CGU6 3.4 66.2 1.0
CG L:CGU6 3.4 65.8 1.0
OE22 L:CGU20 3.5 66.8 1.0
OE12 L:CGU6 3.6 63.0 1.0
CA L:CA504 3.7 38.7 1.0
OE11 L:CGU6 3.7 66.1 1.0
CG L:CGU16 3.8 39.4 1.0
C L:ALA1 4.0 38.8 1.0
CG L:CGU20 4.1 65.8 1.0
NE L:ARG15 4.2 46.2 1.0
N L:ALA1 4.3 38.3 1.0
CA L:CGU16 4.3 38.6 1.0
CB L:CGU6 4.4 62.1 1.0
O L:ARG15 4.4 41.6 1.0
CB L:CGU20 4.5 59.2 1.0
CB L:CGU16 4.5 38.3 1.0
OE21 L:CGU26 4.5 50.9 1.0
CG L:ARG15 4.6 45.3 1.0
CA L:ALA1 4.7 38.1 1.0
N L:CGU16 4.8 37.9 1.0
C L:ARG15 4.8 40.8 1.0
CD L:ARG15 4.8 46.5 1.0
OE12 L:CGU16 4.8 38.6 1.0
CD1 L:CGU16 4.8 38.7 1.0
N L:ASN2 5.0 38.5 1.0

Calcium binding site 6 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 6 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Ca506

b:86.2
occ:1.00
 OE12 L:CGU19 1.7 83.0 1.0
OE12 L:CGU20 1.7 77.5 1.0
OE22 L:CGU20 1.7 66.8 1.0
CD1 L:CGU20 2.7 72.1 1.0
CD2 L:CGU20 2.7 66.1 1.0
CD1 L:CGU19 2.9 76.8 1.0
CG L:CGU20 3.2 65.8 1.0
OE22 L:CGU19 3.5 77.6 1.0
OE11 L:CGU19 3.8 79.2 1.0
OE11 L:CGU20 3.8 76.0 1.0
OE21 L:CGU20 3.9 67.1 1.0
CG L:CGU19 3.9 71.5 1.0
O L:ARG15 4.0 41.6 1.0
CB L:CGU20 4.1 59.2 1.0
CD2 L:CGU19 4.2 74.5 1.0
CB L:CGU19 4.3 64.5 1.0
N L:CGU20 4.4 57.5 1.0
C L:CGU19 4.6 58.4 1.0
CA L:CGU20 4.7 56.7 1.0
CG L:ARG15 4.8 45.3 1.0
O L:CGU19 4.8 57.8 1.0
C L:ARG15 4.9 40.8 1.0

Calcium binding site 7 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 7 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Ca509

b:51.4
occ:1.00
 O L:GLN64 1.7 38.6 1.0
O L:GLY47 1.9 47.3 1.0
OE1 L:GLN49 2.0 41.7 1.0
O L:ASP46 2.3 50.8 1.0
OD1 L:ASP63 2.7 37.2 1.0
OD2 L:ASP63 2.7 39.1 1.0
C L:GLN64 3.0 37.6 1.0
CG L:ASP63 3.1 36.3 1.0
C L:GLY47 3.1 46.8 1.0
CD L:GLN49 3.2 38.6 1.0
C L:ASP46 3.5 48.2 1.0
N L:GLN66 3.7 42.2 1.0
NE2 L:GLN49 3.7 37.6 1.0
N L:GLN64 3.8 38.0 1.0
N L:LEU65 3.9 37.9 1.0
CA L:LEU65 3.9 40.1 1.0
CA L:GLY47 4.1 44.8 1.0
CA L:GLN64 4.1 38.1 1.0
N L:ASP48 4.1 46.4 1.0
N L:GLY47 4.2 44.6 1.0
N L:GLN49 4.2 44.1 1.0
O L:SER67 4.3 25.9 1.0
CA L:ASP48 4.3 47.2 1.0
C L:LEU65 4.3 41.1 1.0
CG L:GLN49 4.5 38.0 1.0
CB L:ASP63 4.6 35.8 1.0
OE1 L:GLN66 4.6 40.4 0.2
CB L:ASP46 4.7 44.9 0.5
CA L:GLN66 4.7 40.7 1.0
CA L:ASP46 4.8 48.3 1.0
C L:ASP63 4.8 36.4 1.0
C L:ASP48 4.8 45.9 1.0
N L:SER67 4.8 35.5 1.0
CB L:GLN49 4.9 41.1 1.0

Calcium binding site 8 out of 8 in 2aei

Go back to Calcium Binding Sites List in 2aei
Calcium binding site 8 out of 8 in the Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Crystal Structure of A Ternary Complex of Factor Viia/Tissue Factor and 2-[[6-[3-(Aminoiminomethyl)Phenoxy]-3,5-Difluro-4-[(1-Methyl-3- Phenylpropyl)Amino]-2-Pyridinyl]Oxy]-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Ca510

b:32.3
occ:1.00
 O H:GLU75 1.6 46.7 1.0
O H:HOH632 1.7 20.2 1.0
O H:ASP72 2.2 12.3 1.0
OE2 H:GLU80 2.4 24.9 1.0
OE2 H:GLU70 2.5 21.6 1.0
C H:GLU75 2.9 46.8 1.0
CD H:GLU70 3.3 20.6 1.0
OE1 H:GLU70 3.3 31.1 1.0
C H:ASP72 3.4 13.1 1.0
CD H:GLU80 3.7 26.3 1.0
N H:HIS76 3.8 47.9 1.0
N H:GLU75 3.8 40.6 1.0
CA H:GLU75 3.8 46.1 1.0
CA H:HIS76 3.9 52.0 1.0
O H:HOH645 4.1 26.4 1.0
N H:ASP72 4.2 15.7 1.0
CA H:ASP72 4.2 14.0 1.0
N H:LEU73 4.4 11.3 1.0
OE1 H:GLU80 4.4 28.7 1.0
CB H:ASP72 4.4 21.1 1.0
CA H:LEU73 4.5 16.0 1.0
CB H:GLU75 4.6 52.7 1.0
N H:ASP77 4.6 50.9 1.0
C H:LEU73 4.7 21.5 1.0
CG H:GLU80 4.7 26.9 1.0
CG H:GLU70 4.7 9.2 1.0
OD2 H:ASP77 4.8 55.5 1.0
CG H:GLU75 4.8 63.9 1.0
C H:HIS76 4.9 49.7 1.0
N H:SER74 4.9 29.5 1.0
N H:HIS71 4.9 18.6 1.0
O H:LEU73 5.0 19.2 1.0
CB H:HIS76 5.0 56.7 1.0

Reference:

J.T.Kohrt, K.J.Filipski, W.L.Cody, C.Cai, D.A.Dudley, C.A.Van Huis, J.A.Willardsen, S.T.Rapundalo, K.Saiya-Cork, R.J.Leadley, L.Narasimhan, E.Zhang, M.Whitlow, M.Adler, K.Mclean, Y.L.Chou, C.Mcknight, D.O.Arnaiz, K.J.Shaw, D.R.Light, J.J.Edmunds. The Discovery of Fluoropyridine-Based Inhibitors of the Factor Viia/Tf Complex. Bioorg.Med.Chem.Lett. V. 15 4752 2005.
ISSN: ISSN 0960-894X
PubMed: 16125385
DOI: 10.1016/J.BMCL.2005.07.059
Page generated: Sat Dec 12 03:31:05 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy