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Calcium in PDB 2c60: Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution

Enzymatic activity of Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution

All present enzymatic activity of Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution:
2.7.1.37;

Protein crystallography data

The structure of Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution, PDB code: 2c60 was solved by J.E.Debreczeni, E.Salah, E.Papagrigoriou, N.Burgess, F.Von Delft, O.Gileadi, M.Sundstrom, A.Edwards, C.Arrowsmith, J.Weigelt, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.72 / 1.25
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 82.800, 42.300, 30.600, 90.00, 106.60, 90.00
R / Rfree (%) 16.5 / 18.2

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution (pdb code 2c60). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution, PDB code: 2c60:

Calcium binding site 1 out of 1 in 2c60

Go back to Calcium Binding Sites List in 2c60
Calcium binding site 1 out of 1 in the Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Phox Domain at 1.25 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1123

b:16.0
occ:1.00
 O A:SER110 2.6 19.4 1.0
O A:MSE113 2.6 16.5 1.0
O A:LEU107 2.6 13.6 1.0
O A:HOH2065 2.8 23.7 1.0
O A:HOH2109 2.9 24.8 1.0
O A:HOH2108 3.0 16.4 1.0
C A:LEU107 3.7 12.6 1.0
C A:SER110 3.8 18.5 1.0
C A:MSE113 3.8 15.6 1.0
CD1 A:LEU107 4.1 14.9 1.0
CA A:ASP108 4.3 14.2 1.0
O A:ASP108 4.4 16.1 1.0
CG A:LEU107 4.4 13.1 1.0
N A:ASP108 4.5 12.6 1.0
C A:ASP108 4.5 14.2 1.0
N A:MSE113 4.5 16.9 1.0
O A:HOH2023 4.6 18.6 1.0
CB A:MSE113 4.6 18.5 0.4
N A:SER110 4.6 16.8 1.0
CA A:MSE113 4.6 17.9 1.0
O A:HOH2070 4.6 27.3 1.0
CA A:SER110 4.6 18.3 1.0
CB A:MSE113 4.7 17.3 0.6
CA A:LEU107 4.7 13.2 1.0
O A:SER111 4.7 20.6 1.0
C A:SER111 4.8 18.7 1.0
O A:HOH2064 4.8 30.5 1.0
CB A:SER110 4.8 18.1 1.0
N A:SER111 4.8 19.5 1.0
CA A:SER111 4.8 20.2 1.0
O A:HOH2066 4.8 31.6 1.0
N A:LYS114 4.8 15.1 1.0
CA A:LYS114 5.0 15.0 1.0

Reference:

J.E.Debreczeni, E.Salah, E.Papagrigoriou, N.Burgess, F.Von Delft, O.Gileadi, M.Sundstrom, A.Edwards, C.Arrowsmith, J.Weigelt, S.Knapp. Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Fox Domain at 1.25 A Resolution To Be Published.
Page generated: Fri Jul 12 09:25:41 2024

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