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Calcium in PDB 2c6c: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid:
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid, PDB code: 2c6c was solved by J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.00
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 103.127, 131.189, 161.225, 90.00, 90.00, 90.00
R / Rfree (%) 19 / 22.5

Other elements in 2c6c:

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid also contains other interesting chemical elements:

Iodine (I) 1 atom
Chlorine (Cl) 1 atom
Zinc (Zn) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid (pdb code 2c6c). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid, PDB code: 2c6c:

Calcium binding site 1 out of 1 in 2c6c

Go back to Calcium Binding Sites List in 2c6c
Calcium binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1753

b:20.5
occ:1.00
O A:TYR272 2.3 22.5 1.0
OE2 A:GLU436 2.4 18.6 1.0
O A:HOH2046 2.4 22.1 1.0
OE2 A:GLU433 2.4 20.0 1.0
O A:THR269 2.5 23.1 1.0
OE1 A:GLU433 2.5 18.7 1.0
OG1 A:THR269 2.5 17.5 1.0
CD A:GLU433 2.8 20.7 1.0
C A:THR269 3.3 20.7 1.0
C A:TYR272 3.4 20.1 1.0
CB A:THR269 3.4 20.2 1.0
CD A:GLU436 3.5 17.8 1.0
OE1 A:GLU436 3.9 17.1 1.0
CA A:THR269 4.0 19.7 1.0
N A:TYR272 4.0 20.4 1.0
CA A:PRO273 4.1 23.1 1.0
N A:PRO273 4.2 22.6 1.0
N A:ALA274 4.2 22.1 1.0
N A:PRO270 4.2 23.1 1.0
CB A:ASP266 4.2 21.6 1.0
CG A:GLU433 4.3 20.1 1.0
CA A:TYR272 4.3 19.7 1.0
C A:PRO273 4.3 23.7 1.0
O A:ASP266 4.5 22.2 1.0
CA A:PRO270 4.5 21.7 1.0
N A:ASP266 4.5 21.5 1.0
N A:GLY271 4.5 23.1 1.0
O A:ALA264 4.6 22.2 1.0
N A:THR269 4.7 23.4 1.0
CG2 A:THR269 4.7 21.4 1.0
CG A:GLU436 4.7 17.9 1.0
C A:PRO270 4.8 23.1 1.0
OD2 A:ASP266 4.8 22.1 1.0
CA A:ASP266 4.9 21.2 1.0
CB A:ALA274 4.9 24.0 1.0
CB A:GLU436 4.9 20.0 1.0
C A:GLY271 5.0 22.5 1.0

Reference:

J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld. Structure of Glutamate Carboxypeptidase II, A Drug Target in Neuronal Damage and Prostate Cancer. Embo J. V. 25 1375 2006.
ISSN: ISSN 0261-4189
PubMed: 16467855
DOI: 10.1038/SJ.EMBOJ.7600969
Page generated: Sat Dec 12 03:33:47 2020

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