Calcium in PDB 2czi: Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions

All present enzymatic activity of Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions:
3.1.3.25;

The structure of Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions, PDB code: 2czi was solved by R.Arai, K.Ito, T.Ohnishi, H.Ohba, T.Yoshikawa, M.Shirouzu, S.Yokoyama, Riken Structural Genomics/Proteomics Initiative(Rsgi), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.13 / 3.00
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	106.295, 106.295, 54.857, 90.00, 90.00, 120.00
R / Rfree (%)	25 / 28.6

The binding sites of Calcium atom in the Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions (pdb code 2czi). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions, PDB code: 2czi:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca289 b:75.9 occ:1.00 OE1 A:GLU81 2.0 61.5 1.0 O A:ILE103 2.1 30.9 1.0 O2 A:PO4291 2.3 50.0 1.0 OD2 A:ASP101 2.4 36.2 1.0 O3 A:PO4291 2.8 66.3 1.0 C A:ILE103 3.1 29.4 1.0 P A:PO4291 3.1 53.5 1.0 CD A:GLU81 3.2 55.2 1.0 CG A:ASP101 3.3 20.1 1.0 OD1 A:ASP101 3.6 20.8 1.0 CA A:ASP104 3.7 30.1 1.0 N A:ASP104 3.8 34.6 1.0 CA A:CA290 3.8 52.6 1.0 OE2 A:GLU81 4.0 71.0 1.0 O1 A:PO4291 4.0 65.7 1.0 N A:ILE103 4.1 24.1 1.0 CA A:ILE103 4.1 25.1 1.0 CG A:GLU81 4.1 49.0 1.0 O4 A:PO4291 4.3 53.7 1.0 OD1 A:ASP58 4.3 33.9 1.0 N A:GLY105 4.5 24.8 1.0 CB A:ILE103 4.6 31.1 1.0 CB A:GLU81 4.6 57.9 1.0 OG1 A:THR106 4.6 50.2 1.0 CB A:ASP101 4.7 20.0 1.0 C A:ASP104 4.7 26.8 1.0 CB A:ASP104 4.8 26.6 1.0 C A:ASP101 4.9 16.3 1.0 CA A:ASP101 5.0 24.3 1.0 OD2 A:ASP104 5.0 41.7 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Human Myo-Inositol Monophosphatase 2 (IMPA2) with Calcium and Phosphate Ions within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca290 b:52.6 occ:1.00 O2 A:PO4291 2.3 50.0 1.0 OD1 A:ASP231 2.5 48.0 1.0 OD1 A:ASP101 2.6 20.8 1.0 OD2 A:ASP104 2.7 41.7 1.0 CG A:ASP231 3.4 51.4 1.0 CG A:ASP101 3.6 20.1 1.0 P A:PO4291 3.6 53.5 1.0 OD2 A:ASP231 3.7 49.4 1.0 CA A:CA289 3.8 75.9 1.0 CG A:ASP104 3.8 31.6 1.0 O1 A:PO4291 3.9 65.7 1.0 OD2 A:ASP101 3.9 36.2 1.0 NE1 A:TRP230 4.1 36.5 1.0 OE1 A:GLU81 4.1 61.5 1.0 O4 A:PO4291 4.2 53.7 1.0 CA A:ASP104 4.2 30.1 1.0 CB A:ASP104 4.3 26.6 1.0 CD1 A:TRP230 4.4 38.8 1.0 CD A:GLU81 4.6 55.2 1.0 O3 A:PO4291 4.7 66.3 1.0 CB A:ASP231 4.8 47.5 1.0 OD1 A:ASP104 4.9 24.3 1.0 CB A:ASP101 4.9 20.0 1.0 N A:GLY105 5.0 24.8 1.0

R.Arai, K.Ito, T.Ohnishi, H.Ohba, R.Akasaka, Y.Bessho, K.Hanawa-Suetsugu, T.Yoshikawa, M.Shirouzu, S.Yokoyama. Crystal Structure of Human Myo-Inositol Monophosphatase 2, the Product of the Putative Susceptibility Gene For Bipolar Disorder, Schizophrenia, and Febrile Seizures Proteins V. 67 732 2007.
ISSN: ISSN 0887-3585
PubMed: 17340635
DOI: 10.1002/PROT.21299