Calcium in PDB 2f1w: Crystal Structure of the Traf-Like Domain of Hausp/USP7

All present enzymatic activity of Crystal Structure of the Traf-Like Domain of Hausp/USP7:
3.1.2.15;

The structure of Crystal Structure of the Traf-Like Domain of Hausp/USP7, PDB code: 2f1w was solved by M.Hu, L.Gu, P.D.Jeffrey, Y.Shi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.65
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	45.172, 52.242, 63.651, 90.00, 90.00, 90.00
R / Rfree (%)	19.4 / 21.2

The binding sites of Calcium atom in the Crystal Structure of the Traf-Like Domain of Hausp/USP7 (pdb code 2f1w). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Crystal Structure of the Traf-Like Domain of Hausp/USP7, PDB code: 2f1w:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Crystal Structure of the Traf-Like Domain of Hausp/USP7


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of the Traf-Like Domain of Hausp/USP7 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca301 b:17.8 occ:1.00 O A:SER84 2.5 17.3 1.0 O A:HOH417 2.9 38.0 1.0 O A:HOH416 2.9 23.0 1.0 OE2 A:GLU83 2.9 41.1 1.0 CD A:GLU83 3.6 39.0 1.0 C A:SER84 3.6 17.2 1.0 OE1 A:GLU83 4.1 41.8 1.0 N A:SER84 4.2 16.3 1.0 CA A:SER84 4.3 14.1 1.0 CG A:GLU83 4.3 32.0 1.0 CB A:SER84 4.4 15.0 1.0 CB A:GLU83 4.6 23.6 1.0 N A:VAL85 4.6 16.0 1.0 O A:HOH388 4.7 30.4 1.0 O A:HOH324 4.7 27.7 1.0 CA A:VAL85 4.8 16.3 1.0

Calcium binding site 2 out of 2 in the Crystal Structure of the Traf-Like Domain of Hausp/USP7


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of the Traf-Like Domain of Hausp/USP7 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca302 b:12.6 occ:1.00 O A:GLY202 2.4 17.0 1.0 O A:HOH386 2.9 41.2 1.0 C A:GLY202 3.5 14.1 1.0 CA A:GLY202 3.9 13.8 1.0 N A:VAL203 4.6 12.2 1.0 O A:HOH393 4.6 25.7 1.0 N A:ALA204 4.8 12.8 1.0 CA A:VAL203 5.0 12.9 1.0

M.Hu, L.Gu, M.Li, P.D.Jeffrey, W.Gu, Y.Shi. Structural Basis of Competitive Recognition of P53 and MDM2 By Hausp/USP7: Implications For the Regulation of the P53-MDM2 Pathway. Plos Biol. V. 4 E27 2006.
ISSN: ISSN 1544-9173
PubMed: 16402859
DOI: 10.1371/JOURNAL.PBIO.0040027