Calcium in PDB 2iic: Calcium Bound Structure of Alpha-11 Giardin

The structure of Calcium Bound Structure of Alpha-11 Giardin, PDB code: 2iic was solved by P.Pathuri, E.T.Nguyen, H.Luecke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.93
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	129.300, 45.285, 131.901, 90.00, 116.39, 90.00
R / Rfree (%)	26.4 / 30.6

The binding sites of Calcium atom in the Calcium Bound Structure of Alpha-11 Giardin (pdb code 2iic). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Calcium Bound Structure of Alpha-11 Giardin, PDB code: 2iic:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Calcium Bound Structure of Alpha-11 Giardin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Calcium Bound Structure of Alpha-11 Giardin within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca401 b:27.0 occ:1.00 O A:ILE56 2.3 58.4 1.0 O A:HOH428 2.5 15.6 1.0 OE2 A:GLU62 2.8 38.9 1.0 O A:LYS53 2.9 55.7 1.0 O A:LYS57 3.0 61.7 1.0 C A:LYS53 3.3 53.6 1.0 C A:ILE56 3.4 60.3 1.0 OD1 A:ASN58 3.6 53.3 1.0 N A:LYS54 3.7 54.2 1.0 C A:LYS57 3.8 60.9 1.0 CA A:LYS54 3.8 55.7 1.0 CD A:GLU62 3.9 38.6 1.0 C A:LYS54 3.9 56.7 1.0 N A:ILE56 4.0 60.6 1.0 CD1 A:ILE56 4.1 61.2 1.0 O A:LEU52 4.1 53.4 1.0 CA A:LYS53 4.1 52.2 1.0 N A:CYS55 4.1 57.5 1.0 CG A:ASN58 4.1 54.6 1.0 CB A:ASN58 4.3 54.9 1.0 CA A:ILE56 4.3 60.7 1.0 N A:ASN58 4.3 58.1 1.0 OE1 D:GLN127 4.4 67.3 1.0 CA A:ASN58 4.4 56.1 1.0 N A:LYS57 4.4 61.5 1.0 O A:LYS54 4.4 57.5 1.0 CG A:GLU62 4.4 38.2 1.0 C A:CYS55 4.6 59.3 1.0 CA A:LYS57 4.6 61.9 1.0 OE1 A:GLU62 4.9 39.3 1.0 CA A:CYS55 4.9 58.7 1.0 C A:LEU52 5.0 52.9 1.0

Calcium binding site 2 out of 4 in the Calcium Bound Structure of Alpha-11 Giardin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Calcium Bound Structure of Alpha-11 Giardin within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca402 b:42.9 occ:1.00 OE2 B:GLU62 2.6 35.9 1.0 O B:LYS53 2.7 56.8 1.0 O B:ILE56 2.9 60.3 1.0 O B:HOH421 2.9 28.2 1.0 OD1 B:ASN58 3.0 50.1 1.0 O B:LYS57 3.2 59.6 1.0 C B:LYS53 3.3 55.3 1.0 CG B:ASN58 3.7 52.8 1.0 CD B:GLU62 3.8 38.3 1.0 N B:LYS54 3.9 55.9 1.0 CA B:LYS54 3.9 56.4 1.0 C B:LYS57 4.0 59.0 1.0 CB B:ASN58 4.0 53.4 1.0 C B:ILE56 4.1 61.2 1.0 CA B:LYS53 4.2 54.0 1.0 CA B:ASN58 4.3 54.4 1.0 C B:LYS54 4.3 57.0 1.0 OD2 A:ASP126 4.3 68.3 1.0 N B:ASN58 4.5 56.2 1.0 CG B:GLU62 4.6 37.8 1.0 O B:LEU52 4.6 53.9 1.0 CD1 B:ILE56 4.6 60.5 1.0 ND2 B:ASN58 4.6 54.4 1.0 N B:CYS55 4.6 57.6 1.0 N B:ILE56 4.7 61.4 1.0 OE1 B:GLU62 4.7 37.5 1.0 O B:LYS54 4.8 57.7 1.0 CG A:ASP126 4.9 68.5 1.0 N B:LYS57 5.0 61.8 1.0

Calcium binding site 3 out of 4 in the Calcium Bound Structure of Alpha-11 Giardin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Calcium Bound Structure of Alpha-11 Giardin within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca403 b:34.3 occ:1.00 OE2 C:GLU62 2.6 38.6 1.0 O C:LYS53 2.8 56.7 1.0 O C:ILE56 2.8 57.1 1.0 OD1 C:ASN58 3.0 53.3 1.0 O C:LYS57 3.0 61.7 1.0 O C:HOH404 3.0 40.7 1.0 O B:ASP126 3.0 64.5 1.0 C C:LYS53 3.4 54.0 1.0 CA B:ASP126 3.5 65.9 1.0 CG C:ASN58 3.6 55.1 1.0 C B:ASP126 3.6 64.9 1.0 CD C:GLU62 3.8 39.1 1.0 C C:LYS57 3.9 60.2 1.0 CB C:ASN58 4.0 54.6 1.0 N C:LYS54 4.0 54.7 1.0 C C:ILE56 4.0 59.5 1.0 CA C:LYS54 4.0 54.9 1.0 O B:VAL125 4.2 65.5 1.0 CA C:ASN58 4.2 55.5 1.0 CA C:LYS53 4.2 52.5 1.0 CB B:ASP126 4.4 68.5 1.0 N C:ASN58 4.4 58.2 1.0 C C:LYS54 4.4 55.1 1.0 CG C:GLU62 4.5 39.1 1.0 CD1 C:ILE56 4.6 62.9 1.0 N B:ASP126 4.6 65.3 1.0 O C:LEU52 4.6 51.7 1.0 ND2 C:ASN58 4.6 56.7 1.0 N C:ILE56 4.7 59.4 1.0 OE1 C:GLU62 4.7 40.3 1.0 N C:CYS55 4.7 56.1 1.0 OD1 B:ASP126 4.7 71.0 1.0 C B:VAL125 4.8 64.9 1.0 CG B:ASP126 4.8 70.8 1.0 N C:LYS57 4.8 60.2 1.0 O C:LYS54 4.9 55.3 1.0 CA C:LYS57 4.9 61.0 1.0 N B:GLN127 4.9 63.0 1.0 CA C:ILE56 4.9 60.0 1.0

Calcium binding site 4 out of 4 in the Calcium Bound Structure of Alpha-11 Giardin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Calcium Bound Structure of Alpha-11 Giardin within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca404 b:33.9 occ:1.00 OE2 D:GLU62 2.6 38.1 1.0 O D:LYS53 2.7 57.3 1.0 OD1 D:ASN58 2.8 54.5 1.0 O D:HOH426 2.8 24.6 1.0 O D:HOH406 3.0 19.4 1.0 O D:ILE56 3.2 58.6 1.0 O D:LYS57 3.2 62.7 1.0 C D:LYS53 3.4 55.5 1.0 CG D:ASN58 3.5 56.2 1.0 CD D:GLU62 3.8 39.4 1.0 CB D:ASN58 3.9 56.5 1.0 N D:LYS54 4.1 55.8 1.0 CA D:LYS54 4.1 56.6 1.0 C D:LYS57 4.1 61.5 1.0 CA D:ASN58 4.3 57.5 1.0 CA D:LYS53 4.3 54.5 1.0 C D:ILE56 4.3 60.8 1.0 ND2 D:ASN58 4.4 56.8 1.0 C D:LYS54 4.5 57.6 1.0 N D:ASN58 4.5 59.6 1.0 OE1 D:GLU62 4.6 39.0 1.0 CG D:GLU62 4.7 38.4 1.0 CD1 D:ILE56 4.8 62.5 1.0 O D:LEU52 4.9 54.2 1.0 N D:CYS55 4.9 58.0 1.0 O D:LYS54 4.9 58.0 1.0 N D:ILE56 5.0 60.6 1.0

P.Pathuri, E.T.Nguyen, S.G.Svard, H.Luecke. Apo and Calcium-Bound Crystal Structures of Alpha-11 Giardin, An Unusual Annexin From Giardia Lamblia J.Mol.Biol. V. 368 493 2007.
ISSN: ISSN 0022-2836
PubMed: 17355882
DOI: 10.1016/J.JMB.2007.02.016