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Calcium in PDB 2jbj: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid)

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid)

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid):
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid), PDB code: 2jbj was solved by J.R.Mesters, K.Henning, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 101.02 / 2.19
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 100.755, 130.982, 159.611, 90.00, 90.00, 90.00
R / Rfree (%) 19.2 / 23.8

Other elements in 2jbj:

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid) also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Zinc (Zn) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid) (pdb code 2jbj). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid), PDB code: 2jbj:

Calcium binding site 1 out of 1 in 2jbj

Go back to Calcium Binding Sites List in 2jbj
Calcium binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1753

b:30.5
occ:1.00
 O A:HOH2119 2.3 26.3 1.0
O A:THR269 2.3 32.0 1.0
O A:TYR272 2.4 31.7 1.0
OE1 A:GLU433 2.4 29.6 1.0
OE2 A:GLU436 2.4 32.3 1.0
OE2 A:GLU433 2.4 28.8 1.0
OG1 A:THR269 2.6 27.6 1.0
CD A:GLU433 2.8 28.4 1.0
C A:THR269 3.3 30.9 1.0
C A:TYR272 3.4 31.3 1.0
CB A:THR269 3.4 29.5 1.0
CD A:GLU436 3.5 31.0 1.0
OE1 A:GLU436 3.9 29.8 1.0
CA A:THR269 4.0 30.4 1.0
N A:TYR272 4.1 32.1 1.0
N A:ALA274 4.1 32.6 1.0
CA A:PRO273 4.2 32.9 1.0
N A:PRO273 4.2 31.8 1.0
CG A:GLU433 4.2 27.5 1.0
CB A:ASP266 4.2 29.2 1.0
N A:PRO270 4.3 30.5 1.0
C A:PRO273 4.4 33.2 1.0
O A:ASP266 4.4 30.3 1.0
CA A:TYR272 4.4 31.2 1.0
N A:ASP266 4.5 30.1 1.0
CA A:PRO270 4.5 30.0 1.0
O A:ALA264 4.5 29.0 1.0
N A:GLY271 4.6 30.4 1.0
CG A:GLU436 4.7 28.8 1.0
N A:THR269 4.7 30.3 1.0
CG2 A:THR269 4.8 28.6 1.0
C A:PRO270 4.8 30.3 1.0
CA A:ASP266 4.8 28.9 1.0
OD2 A:ASP266 4.8 30.9 1.0
CB A:ALA274 4.9 32.5 1.0
CA A:GLU433 4.9 25.8 1.0
CB A:GLU433 5.0 27.1 1.0
CA A:ALA274 5.0 33.1 1.0

Reference:

J.R.Mesters, K.Henning, R.Hilgenfeld. Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa. Acta Crystallogr.,Sect.D V. 63 508 2007.
ISSN: ISSN 0907-4449
PubMed: 17372356
DOI: 10.1107/S090744490700902X
Page generated: Fri Jul 12 13:33:18 2024

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