Calcium in PDB 2jbk: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid):
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid), PDB code: 2jbk was solved by J.R.Mesters, K.Henning, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	100.00 / 2.99
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	103.144, 130.758, 159.992, 90.00, 90.00, 90.00
*R / R_free (%)*	21 / n/a

Other elements in 2jbk:

Chlorine	(Cl)	1 atom
Zinc	(Zn)	2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid) (pdb code 2jbk). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid), PDB code: 2jbk:

Calcium binding site 1 out of 1 in 2jbk

Go back to

Calcium Binding Sites List in 2jbk

Calcium binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca803 b:35.0 occ:1.00	O	A:THR269	2.3	35.0	1.0
	OE2	A:GLU433	2.3	35.0	1.0
	O	A:TYR272	2.3	35.0	1.0
	OE1	A:GLU433	2.4	35.0	1.0
	OE2	A:GLU436	2.4	35.0	1.0
	OG1	A:THR269	2.5	35.0	1.0
	CD	A:GLU433	2.7	35.0	1.0
	C	A:THR269	3.3	35.0	1.0
	CB	A:THR269	3.3	35.0	1.0
	C	A:TYR272	3.5	35.0	1.0
	CD	A:GLU436	3.6	35.0	1.0
	CA	A:THR269	3.9	35.0	1.0
	CG	A:GLU433	4.2	35.0	1.0
	O	A:ASP266	4.2	35.0	1.0
	OE1	A:GLU436	4.2	35.0	1.0
	N	A:ALA274	4.3	35.0	1.0
	OD2	A:ASP266	4.3	35.0	1.0
	N	A:TYR272	4.3	35.0	1.0
	CA	A:PRO273	4.3	35.0	1.0
	O	A:ALA264	4.3	35.0	1.0
	N	A:PRO273	4.3	35.0	1.0
	C	A:PRO273	4.3	35.0	1.0
	CB	A:ASP266	4.4	35.0	1.0
	N	A:PRO270	4.4	35.0	1.0
	N	A:ASP266	4.5	35.0	1.0
	N	A:GLY271	4.5	35.0	1.0
	CA	A:TYR272	4.6	35.0	1.0
	CA	A:PRO270	4.6	35.0	1.0
	CG2	A:THR269	4.6	35.0	1.0
	N	A:THR269	4.6	35.0	1.0
	CG	A:GLU436	4.8	35.0	1.0
	CB	A:ALA274	4.8	35.0	1.0
	C	A:PRO270	4.8	35.0	1.0
	CA	A:GLU433	4.8	35.0	1.0
	CG	A:ASP266	4.8	35.0	1.0
	CB	A:GLU433	4.8	35.0	1.0
	CA	A:ASP266	4.9	35.0	1.0
	CB	A:GLU436	5.0	35.0	1.0
	C	A:ASP266	5.0	35.0	1.0
	O	A:PRO273	5.0	35.0	1.0

Reference:

J.R.Mesters, K.Henning, R.Hilgenfeld. Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa. Acta Crystallogr.,Sect.D V. 63 508 2007.
ISSN: ISSN 0907-4449
PubMed: 17372356
DOI: 10.1107/S090744490700902X

Page generated: Sat Dec 12 03:41:43 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy