Calcium in PDB 2jbk: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid):
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid), PDB code: 2jbk was solved by J.R.Mesters, K.Henning, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	100.00 / 2.99
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	103.144, 130.758, 159.992, 90.00, 90.00, 90.00
*R / R_free (%)*	21 / n/a

Other elements in 2jbk:

Chlorine	(Cl)	1 atom
Zinc	(Zn)	2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid) (pdb code 2jbk). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid), PDB code: 2jbk:

Calcium binding site 1 out of 1 in 2jbk

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Calcium Binding Sites List in 2jbk

Calcium binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid)

Mono view

Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Quisqualic Acid (Quisqualate, Alpha-Amino-3,5-Dioxo-1,2,4- Oxadiazolidine-2-Propanoic Acid) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ca803 b:35.0 occ:1.00	O	A:THR269	2.3	35.0	1.0
	OE2	A:GLU433	2.3	35.0	1.0
	O	A:TYR272	2.3	35.0	1.0
	OE1	A:GLU433	2.4	35.0	1.0
	OE2	A:GLU436	2.4	35.0	1.0
	OG1	A:THR269	2.5	35.0	1.0
	CD	A:GLU433	2.7	35.0	1.0
	C	A:THR269	3.3	35.0	1.0
	CB	A:THR269	3.3	35.0	1.0
	C	A:TYR272	3.5	35.0	1.0
	CD	A:GLU436	3.6	35.0	1.0
	CA	A:THR269	3.9	35.0	1.0
	CG	A:GLU433	4.2	35.0	1.0
	O	A:ASP266	4.2	35.0	1.0
	OE1	A:GLU436	4.2	35.0	1.0
	N	A:ALA274	4.3	35.0	1.0
	OD2	A:ASP266	4.3	35.0	1.0
	N	A:TYR272	4.3	35.0	1.0
	CA	A:PRO273	4.3	35.0	1.0
	O	A:ALA264	4.3	35.0	1.0
	N	A:PRO273	4.3	35.0	1.0
	C	A:PRO273	4.3	35.0	1.0
	CB	A:ASP266	4.4	35.0	1.0
	N	A:PRO270	4.4	35.0	1.0
	N	A:ASP266	4.5	35.0	1.0
	N	A:GLY271	4.5	35.0	1.0
	CA	A:TYR272	4.6	35.0	1.0
	CA	A:PRO270	4.6	35.0	1.0
	CG2	A:THR269	4.6	35.0	1.0
	N	A:THR269	4.6	35.0	1.0
	CG	A:GLU436	4.8	35.0	1.0
	CB	A:ALA274	4.8	35.0	1.0
	C	A:PRO270	4.8	35.0	1.0
	CA	A:GLU433	4.8	35.0	1.0
	CG	A:ASP266	4.8	35.0	1.0
	CB	A:GLU433	4.8	35.0	1.0
	CA	A:ASP266	4.9	35.0	1.0
	CB	A:GLU436	5.0	35.0	1.0
	C	A:ASP266	5.0	35.0	1.0
	O	A:PRO273	5.0	35.0	1.0

Reference:

J.R.Mesters, K.Henning, R.Hilgenfeld. Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa. Acta Crystallogr.,Sect.D V. 63 508 2007.
ISSN: ISSN 0907-4449
PubMed: 17372356
DOI: 10.1107/S090744490700902X

Page generated: Fri Jul 12 13:33:19 2024

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