Calcium in PDB 2m0p: Solution Structure of the Tenth Complement Type Repeat of Human Megalin

The binding sites of Calcium atom in the Solution Structure of the Tenth Complement Type Repeat of Human Megalin (pdb code 2m0p). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Solution Structure of the Tenth Complement Type Repeat of Human Megalin, PDB code: 2m0p:

Calcium binding site 1 out of 1 in the Solution Structure of the Tenth Complement Type Repeat of Human Megalin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Solution Structure of the Tenth Complement Type Repeat of Human Megalin within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1201 b:0.3 occ:1.00 OD2 A:ASP1139 2.2 0.3 1.0 OD1 A:ASP1129 2.2 0.3 1.0 OD2 A:ASP1133 2.2 1.0 1.0 OE2 A:GLU1140 2.2 0.3 1.0 O A:ASP1131 2.3 0.5 1.0 O A:TRP1126 2.3 0.3 1.0 H A:ASP1129 3.0 0.2 1.0 CG A:ASP1139 3.3 0.3 1.0 H A:ASP1133 3.3 1.1 1.0 HB3 A:TRP1126 3.3 0.3 1.0 CG A:ASP1129 3.3 0.3 1.0 CG A:ASP1133 3.4 0.6 1.0 CD A:GLU1140 3.4 0.3 1.0 C A:TRP1126 3.4 0.2 1.0 C A:ASP1131 3.4 0.7 1.0 H A:ASP1131 3.5 0.6 1.0 HB2 A:ASP1133 3.5 1.0 1.0 HG2 A:GLU1140 3.6 0.3 1.0 H A:CYS1128 3.6 0.2 1.0 HA A:ASN1132 3.7 1.0 1.0 OD1 A:ASP1139 3.8 0.3 1.0 N A:ASP1133 3.8 0.9 1.0 HA A:VAL1127 3.9 0.2 1.0 N A:ASP1129 3.9 0.2 1.0 CB A:ASP1133 3.9 0.7 1.0 HB3 A:ASP1131 4.0 0.7 1.0 CG A:GLU1140 4.0 0.3 1.0 N A:CYS1128 4.1 0.2 1.0 OD2 A:ASP1129 4.1 0.5 1.0 CB A:TRP1126 4.2 0.2 1.0 HB3 A:ASP1129 4.2 0.3 1.0 N A:ASP1131 4.2 0.6 1.0 CA A:TRP1126 4.2 0.2 1.0 CB A:ASP1129 4.2 0.3 1.0 N A:ASN1132 4.3 0.9 1.0 CA A:ASN1132 4.3 1.0 1.0 HA A:TRP1126 4.3 0.2 1.0 CA A:ASP1131 4.3 0.7 1.0 N A:VAL1127 4.3 0.2 1.0 C A:ASN1132 4.3 0.9 1.0 HB2 A:ASP1139 4.4 0.2 1.0 OD1 A:ASP1133 4.4 1.1 1.0 OE1 A:GLU1140 4.4 0.4 1.0 HG3 A:GLU1140 4.4 0.3 1.0 CA A:VAL1127 4.5 0.2 1.0 CA A:ASP1133 4.5 0.8 1.0 CB A:ASP1139 4.5 0.2 1.0 HD11 A:ILE1122 4.5 1.1 1.0 CA A:ASP1129 4.5 0.3 1.0 HB2 A:TRP1126 4.6 0.3 1.0 C A:VAL1127 4.6 0.2 1.0 CB A:ASP1131 4.7 0.8 1.0 HA A:CYS1128 4.7 0.3 1.0 C A:ASP1129 4.8 0.4 1.0 H A:THR1130 4.8 0.5 1.0 CA A:CYS1128 4.9 0.3 1.0 C A:CYS1128 4.9 0.3 1.0 HB3 A:ASP1133 4.9 1.1 1.0 N A:THR1130 5.0 0.5 1.0 HA A:ASP1133 5.0 0.9 1.0

R.Dagil, C.O'shea, A.Nykjar, A.M.Bonvin, B.B.Kragelund. Gentamicin Binds to the Megalin Receptor As A Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: Insight From the uc(Nmr) Structure of the 10TH Complement Type Repeat Domain Alone and in Complex with Gentamicin. J.Biol.Chem. V. 288 4424 2013.
ISSN: ISSN 0021-9258
PubMed: 23275343
DOI: 10.1074/JBC.M112.434159