Calcium in PDB 2mlr: Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face

All present enzymatic activity of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face:
3.4.24.65;

The structure of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face also contains other interesting chemical elements:

Zinc

(Zn)

28 atoms

The binding sites of Calcium atom in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face (pdb code 2mlr). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face, PDB code: 2mlr:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca303 b:0.0 occ:1.00 OD2 A:ASP198 2.2 0.0 1.0 OD1 A:ASP175 2.2 0.0 1.0 O A:GLY176 2.3 0.0 1.0 OE2 A:GLU201 2.3 0.0 1.0 OD2 A:ASP175 2.4 0.0 1.0 O A:GLY178 2.4 0.0 1.0 O A:ILE180 2.4 0.0 1.0 CG A:ASP175 2.7 0.0 1.0 H A:ILE180 3.3 0.0 1.0 CG A:ASP198 3.4 0.0 1.0 C A:GLY176 3.5 0.0 1.0 H A:GLY176 3.5 0.0 1.0 C A:ILE180 3.5 0.0 1.0 H A:GLY178 3.5 0.0 1.0 CD A:GLU201 3.5 0.0 1.0 C A:GLY178 3.6 0.0 1.0 HD23 A:LEU181 3.8 0.0 1.0 N A:ILE180 3.9 0.0 1.0 HB3 A:ASP198 3.9 0.0 1.0 HA A:LEU181 3.9 0.0 1.0 HG2 A:GLU201 3.9 0.0 1.0 N A:GLY176 3.9 0.0 1.0 N A:GLY178 4.0 0.0 1.0 CB A:ASP175 4.2 0.0 1.0 CB A:ASP198 4.3 0.0 1.0 OD1 A:ASP198 4.3 0.0 1.0 HA3 A:GLY179 4.3 0.0 1.0 CA A:GLY176 4.3 0.0 1.0 CA A:ILE180 4.4 0.0 1.0 HB A:ILE180 4.4 0.0 1.0 CG A:GLU201 4.4 0.0 1.0 HB3 A:ASP200 4.4 0.0 1.0 CA A:GLY178 4.4 0.0 1.0 OE1 A:GLU201 4.4 0.0 1.0 N A:LEU181 4.4 0.0 1.0 N A:LYS177 4.5 0.0 1.0 HA A:LYS177 4.5 0.0 1.0 HD2 A:PHE174 4.5 0.0 1.0 N A:GLY179 4.5 0.0 1.0 HB2 A:ASP175 4.6 0.0 1.0 CA A:LEU181 4.6 0.0 1.0 HB2 A:ASP198 4.6 0.0 1.0 C A:GLY179 4.6 0.0 1.0 C A:LYS177 4.6 0.0 1.0 C A:ASP175 4.6 0.0 1.0 CA A:GLY179 4.7 0.0 1.0 HG3 A:GLU201 4.7 0.0 1.0 HB3 A:ASP175 4.8 0.0 1.0 HA2 A:GLY178 4.8 0.0 1.0 CA A:LYS177 4.8 0.0 1.0 CA A:ASP175 4.9 0.0 1.0 CD2 A:LEU181 4.9 0.0 1.0 CB A:ILE180 4.9 0.0 1.0 HE2 A:PHE174 4.9 0.0 1.0 HA2 A:GLY176 5.0 0.0 1.0

Calcium binding site 2 out of 3 in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca304 b:0.0 occ:1.00 OD2 A:ASP194 2.2 0.0 1.0 O A:ASP158 2.3 0.0 1.0 OD1 A:ASP194 2.3 0.0 1.0 CG A:ASP194 2.7 0.0 1.0 C A:ASP158 3.4 0.0 1.0 HH2 A:TRP109 3.6 0.0 1.0 H A:LEU160 3.7 0.0 1.0 O A:GLY193 3.8 0.0 1.0 HZ2 A:TRP109 4.0 0.0 1.0 HA A:ASP158 4.0 0.0 1.0 HA A:ILE159 4.0 0.0 1.0 O A:ALA157 4.0 0.0 1.0 HB2 A:LEU160 4.1 0.0 1.0 CB A:ASP194 4.1 0.0 1.0 C A:GLY193 4.2 0.0 1.0 CA A:ASP158 4.3 0.0 1.0 N A:ILE159 4.3 0.0 1.0 CH2 A:TRP109 4.3 0.0 1.0 HA3 A:GLY193 4.4 0.0 1.0 N A:LEU160 4.5 0.0 1.0 CZ2 A:TRP109 4.6 0.0 1.0 N A:ASP194 4.6 0.0 1.0 HA A:ASP194 4.6 0.0 1.0 CA A:ILE159 4.6 0.0 1.0 C A:ALA157 4.7 0.0 1.0 HB2 A:ASP194 4.7 0.0 1.0 N A:ASP158 4.7 0.0 1.0 CA A:ASP194 4.7 0.0 1.0 HB3 A:ASP194 4.8 0.0 1.0 CA A:GLY193 4.8 0.0 1.0 O A:GLY192 4.8 0.0 1.0 HB3 A:LEU160 4.9 0.0 1.0 HB2 A:ALA157 4.9 0.0 1.0 C A:ILE159 5.0 0.0 1.0 CB A:LEU160 5.0 0.0 1.0

Calcium binding site 3 out of 3 in the Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Membrane Bilayer Complex with Matrix Metalloproteinase-12 at Its Alpha-Face within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca305 b:0.0 occ:1.00 OD2 A:ASP124 2.3 0.0 1.0 OE2 A:GLU199 2.3 0.0 1.0 O A:GLU199 2.4 0.0 1.0 OE1 A:GLU199 2.4 0.0 1.0 CD A:GLU199 2.7 0.0 1.0 O A:GLU201 2.8 0.0 1.0 CG A:ASP124 3.2 0.0 1.0 OD1 A:ASP124 3.4 0.0 1.0 C A:GLU199 3.5 0.0 1.0 HG1 A:THR122 3.6 0.0 1.0 HD1 A:TRP203 3.8 0.0 1.0 C A:GLU201 3.9 0.0 1.0 HA A:GLU199 4.0 0.0 1.0 HA A:PHE202 4.1 0.0 1.0 CG A:GLU199 4.1 0.0 1.0 CA A:GLU199 4.2 0.0 1.0 HD2 A:PRO123 4.3 0.0 1.0 HA A:ASP200 4.3 0.0 1.0 H A:TRP203 4.3 0.0 1.0 OG1 A:THR122 4.4 0.0 1.0 C A:ASP200 4.5 0.0 1.0 N A:ASP200 4.5 0.0 1.0 CB A:ASP124 4.5 0.0 1.0 N A:GLU201 4.5 0.0 1.0 CB A:GLU199 4.5 0.0 1.0 HG2 A:GLU199 4.6 0.0 1.0 HB2 A:ASP124 4.6 0.0 1.0 CA A:ASP200 4.6 0.0 1.0 H A:GLU201 4.7 0.0 1.0 HG3 A:GLU199 4.7 0.0 1.0 CD1 A:TRP203 4.7 0.0 1.0 N A:PHE202 4.8 0.0 1.0 HB3 A:GLU199 4.9 0.0 1.0 CA A:GLU201 4.9 0.0 1.0 HG2 A:PRO123 4.9 0.0 1.0 O A:ASP200 5.0 0.0 1.0 CA A:PHE202 5.0 0.0 1.0

R.K.Koppisetti, Y.G.Fulcher, A.Jurkevich, S.H.Prior, J.Xu, M.Lenoir, M.Overduin, S.R.Van Doren. Ambidextrous Binding of Cell and Membrane Bilayers By Soluble Matrix Metalloproteinase-12. Nat Commun V. 5 5552 2014.
ISSN: ESSN 2041-1723
PubMed: 25412686
DOI: 10.1038/NCOMMS6552