Calcium in PDB 2noz: Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna

All present enzymatic activity of Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna:
4.2.99.18;

The structure of Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna, PDB code: 2noz was solved by C.T.Radom, A.Banerjee, G.L.Verdine, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.43
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	92.391, 92.391, 210.713, 90.00, 90.00, 120.00
R / Rfree (%)	23.8 / 27.5

The binding sites of Calcium atom in the Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna (pdb code 2noz). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna, PDB code: 2noz:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca301 b:89.6 occ:1.00 OP2 C:DA22 3.8 70.8 1.0 N7 C:DG24 4.2 63.3 1.0 C8 C:DA22 4.2 63.1 1.0 N7 C:DA22 4.3 63.1 1.0 OP1 C:DG24 4.5 77.1 1.0 O C:HOH8 4.6 38.5 1.0 OP2 C:DG24 4.7 77.4 1.0 C8 C:DG24 4.8 63.4 1.0 OD1 A:ASN149 4.8 53.7 1.0

Calcium binding site 2 out of 2 in the Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Q315F Human 8-Oxoguanine Glycosylase Distal Crosslink to 8-Oxoguanine Dna within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca302 b:67.3 occ:1.00 O A:CYS241 2.7 36.7 1.0 O A:VAL246 2.9 36.8 1.0 OP1 C:DC26 2.9 57.5 1.0 O A:LEU243 3.0 35.1 1.0 OP2 C:DC26 3.1 56.2 1.0 O A:HOH415 3.1 52.3 1.0 P C:DC26 3.5 57.5 1.0 C A:CYS241 3.7 36.2 1.0 C A:VAL246 3.8 36.8 1.0 C A:LEU243 3.8 33.5 1.0 N A:VAL246 4.0 36.8 1.0 C A:ILE242 4.2 35.8 1.0 O A:ILE242 4.2 34.6 1.0 CA A:VAL246 4.3 36.7 1.0 N A:LEU243 4.4 35.2 1.0 CA A:PRO244 4.4 34.4 1.0 N A:GLY245 4.4 37.5 1.0 N A:PRO244 4.4 34.0 1.0 O3' C:DT25 4.5 58.5 1.0 CA A:CYS241 4.5 36.5 1.0 CA A:ILE242 4.6 35.8 1.0 N A:ILE242 4.6 35.9 1.0 CB A:VAL246 4.7 35.8 1.0 CA A:LEU243 4.7 33.5 1.0 O5' C:DC26 4.7 58.8 1.0 N A:GLY247 4.7 37.3 1.0 C A:PRO244 4.7 36.7 1.0

C.T.Radom, A.Banerjee, G.L.Verdine. Structural Characterization of Human 8-Oxoguanine Dna Glycosylase Variants Bearing Active Site Mutations. J.Biol.Chem. V. 282 9182 2007.
ISSN: ISSN 0021-9258
PubMed: 17114185
DOI: 10.1074/JBC.M608989200