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Calcium in PDB 2nq6: Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide

Enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide

All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide, PDB code: 2nq6 was solved by A.Addlagatta, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.320, 77.825, 48.229, 90.00, 90.48, 90.00
R / Rfree (%) 17.3 / 20.3

Other elements in 2nq6:

The structure of Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide also contains other interesting chemical elements:

Cobalt (Co) 3 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide (pdb code 2nq6). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide, PDB code: 2nq6:

Calcium binding site 1 out of 1 in 2nq6

Go back to Calcium Binding Sites List in 2nq6
Calcium binding site 1 out of 1 in the Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human Methionine Aminopeptidase Type 1 in Complex with 3-Tert-Butoxycarbonylaminopyridine-2-Carboxylic Acid Thiazole-2- Ylamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca404

b:18.9
occ:1.00
 O A:HOH785 2.4 22.2 0.5
O A:VAL209 2.6 12.0 1.0
O A:SER363 2.7 12.8 1.0
O A:HOH537 2.8 16.6 1.0
O A:ASN207 2.9 13.7 1.0
O A:SER205 3.1 12.0 1.0
N A:ASN207 3.6 13.6 1.0
C A:ASN207 3.7 11.5 1.0
C A:SER205 3.7 8.8 1.0
C A:VAL206 3.7 12.8 1.0
C A:SER363 3.7 10.2 1.0
C A:VAL209 3.7 10.1 1.0
CA A:ASN207 4.0 11.7 1.0
O A:VAL206 4.1 11.1 1.0
CB A:SER205 4.2 9.9 1.0
N A:VAL206 4.2 10.5 1.0
CA A:VAL206 4.2 14.2 1.0
N A:VAL209 4.2 11.0 1.0
O A:HOH549 4.5 12.0 1.0
N A:SER363 4.5 11.4 1.0
CA A:VAL209 4.5 10.3 1.0
CA A:SER363 4.5 10.9 1.0
CB A:SER363 4.6 14.8 1.0
CA A:SER205 4.6 8.5 1.0
N A:ALA364 4.6 10.5 1.0
CG1 A:ILE225 4.7 11.5 1.0
CB A:VAL209 4.8 9.7 1.0
N A:ILE210 4.8 10.1 1.0
CA A:ALA364 4.8 10.6 1.0
N A:GLU208 4.8 11.1 1.0
O A:ILE225 4.8 13.6 1.0
CD1 A:ILE225 4.8 14.2 1.0
C A:GLU208 4.9 12.3 1.0
O A:HOH488 4.9 12.1 1.0
CA A:ILE210 5.0 9.3 1.0
N A:ASN227 5.0 9.0 1.0

Reference:

X.Hu, A.Addlagatta, J.Lu, B.W.Matthews, J.O.Liu. Elucidation of the Function of Type 1 Human Methionine Aminopeptidase During Cell Cycle Progression. Proc.Natl.Acad.Sci.Usa V. 103 18148 2006.
ISSN: ISSN 0027-8424
PubMed: 17114291
DOI: 10.1073/PNAS.0608389103
Page generated: Fri Jul 12 14:27:58 2024

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