Calcium in PDB 2ow1: Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Enzymatic activity of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
All present enzymatic activity of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor:
3.4.24.35;
Protein crystallography data
The structure of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor, PDB code: 2ow1
was solved by
A.Tochowicz,
W.Bode,
K.Maskos,
P.Goettig,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
19.79 /
2.20
|
Space group
|
P 41 21 2
|
Cell size a, b, c (Å), α, β, γ (°)
|
55.720,
55.720,
260.450,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
21.7 /
26.7
|
Other elements in 2ow1:
The structure of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor also contains other interesting chemical elements:
Calcium Binding Sites:
The binding sites of Calcium atom in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
(pdb code 2ow1). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the
Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor, PDB code: 2ow1:
Jump to Calcium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Calcium binding site 1 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 1 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca446
b:21.0
occ:1.00
|
OE2
|
A:GLU208
|
2.1
|
20.3
|
1.0
|
O
|
A:GLY183
|
2.2
|
41.9
|
1.0
|
O
|
A:ASP185
|
2.4
|
39.2
|
1.0
|
OD2
|
A:ASP205
|
2.4
|
15.6
|
1.0
|
O
|
A:LEU187
|
2.4
|
24.6
|
1.0
|
OD1
|
A:ASP182
|
2.5
|
37.0
|
1.0
|
C
|
A:GLY183
|
3.3
|
41.2
|
1.0
|
CD
|
A:GLU208
|
3.4
|
20.4
|
1.0
|
CG
|
A:ASP205
|
3.4
|
16.8
|
1.0
|
CG
|
A:ASP182
|
3.5
|
38.0
|
1.0
|
N
|
A:GLY183
|
3.5
|
41.6
|
1.0
|
C
|
A:LEU187
|
3.5
|
28.9
|
1.0
|
C
|
A:ASP185
|
3.6
|
40.4
|
1.0
|
OD2
|
A:ASP182
|
3.8
|
38.4
|
1.0
|
N
|
A:LEU187
|
3.9
|
34.6
|
1.0
|
CA
|
A:GLY183
|
4.0
|
40.9
|
1.0
|
CB
|
A:ASP205
|
4.0
|
16.8
|
1.0
|
N
|
A:ASP185
|
4.1
|
41.7
|
1.0
|
CG
|
A:GLU208
|
4.1
|
20.1
|
1.0
|
CA
|
A:LEU187
|
4.2
|
32.4
|
1.0
|
C
|
A:LYS184
|
4.2
|
41.8
|
1.0
|
C
|
A:GLY186
|
4.2
|
36.4
|
1.0
|
OE1
|
A:GLU208
|
4.3
|
20.6
|
1.0
|
CA
|
A:ASP185
|
4.4
|
41.4
|
1.0
|
OD1
|
A:ASP205
|
4.4
|
13.6
|
1.0
|
N
|
A:LYS184
|
4.4
|
41.4
|
1.0
|
N
|
A:ASP182
|
4.5
|
32.5
|
1.0
|
N
|
A:LEU188
|
4.5
|
25.9
|
1.0
|
N
|
A:GLY186
|
4.5
|
39.2
|
1.0
|
CB
|
A:LEU187
|
4.6
|
36.1
|
1.0
|
O
|
A:LYS184
|
4.6
|
41.3
|
1.0
|
C
|
A:ASP182
|
4.6
|
39.9
|
1.0
|
CA
|
A:GLY186
|
4.6
|
37.9
|
1.0
|
CA
|
A:LYS184
|
4.7
|
42.4
|
1.0
|
CB
|
A:ASP182
|
4.7
|
38.0
|
1.0
|
CA
|
A:LEU188
|
4.8
|
22.2
|
1.0
|
O
|
A:GLY186
|
4.8
|
37.4
|
1.0
|
CA
|
A:ASP182
|
4.8
|
37.7
|
1.0
|
|
Calcium binding site 2 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 2 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 2 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca447
b:23.1
occ:1.00
|
O
|
A:HOH594
|
2.3
|
10.3
|
1.0
|
O
|
A:GLY197
|
2.4
|
21.8
|
1.0
|
O
|
A:GLN199
|
2.4
|
16.9
|
1.0
|
O
|
A:ASP165
|
2.4
|
14.7
|
1.0
|
OD1
|
A:ASP201
|
2.5
|
14.8
|
1.0
|
O
|
A:HOH505
|
2.5
|
11.5
|
1.0
|
CG
|
A:ASP201
|
3.4
|
13.9
|
1.0
|
C
|
A:GLN199
|
3.6
|
17.0
|
1.0
|
C
|
A:GLY197
|
3.6
|
21.9
|
1.0
|
C
|
A:ASP165
|
3.6
|
17.3
|
1.0
|
OD2
|
A:ASP201
|
3.9
|
12.2
|
1.0
|
O
|
A:HOH568
|
4.0
|
26.1
|
1.0
|
O
|
A:ALA164
|
4.1
|
20.7
|
1.0
|
C
|
A:ILE198
|
4.1
|
20.3
|
1.0
|
N
|
A:ASP201
|
4.1
|
12.9
|
1.0
|
N
|
A:GLN199
|
4.2
|
19.4
|
1.0
|
O
|
A:ILE198
|
4.2
|
19.4
|
1.0
|
CA
|
A:ASP165
|
4.3
|
18.4
|
1.0
|
C
|
A:GLY200
|
4.3
|
13.6
|
1.0
|
O
|
A:GLY195
|
4.3
|
19.0
|
1.0
|
CA
|
A:GLY200
|
4.4
|
13.8
|
1.0
|
N
|
A:GLY200
|
4.4
|
17.0
|
1.0
|
N
|
A:GLY197
|
4.5
|
23.6
|
1.0
|
N
|
A:ILE198
|
4.5
|
22.0
|
1.0
|
CA
|
A:ILE198
|
4.5
|
21.1
|
1.0
|
CA
|
A:GLN199
|
4.5
|
19.9
|
1.0
|
CA
|
A:GLY197
|
4.5
|
22.6
|
1.0
|
N
|
A:ILE166
|
4.6
|
15.8
|
1.0
|
CB
|
A:ASP201
|
4.6
|
10.7
|
1.0
|
N
|
A:VAL167
|
4.7
|
14.6
|
1.0
|
CG2
|
A:VAL167
|
4.7
|
16.9
|
1.0
|
CA
|
A:ASP201
|
4.7
|
12.4
|
1.0
|
CA
|
A:ILE166
|
4.7
|
14.9
|
1.0
|
C
|
A:PRO196
|
4.8
|
23.3
|
1.0
|
O
|
A:HOH528
|
4.9
|
15.8
|
1.0
|
CH2
|
A:TRP116
|
4.9
|
17.4
|
1.0
|
|
Calcium binding site 3 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 3 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 3 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca448
b:46.1
occ:1.00
|
O
|
A:ASP206
|
2.4
|
16.6
|
1.0
|
O
|
A:GLU208
|
2.4
|
20.2
|
1.0
|
OD2
|
A:ASP131
|
2.4
|
16.2
|
1.0
|
OD1
|
A:ASP206
|
2.8
|
26.2
|
1.0
|
CG
|
A:ASP131
|
3.2
|
15.7
|
1.0
|
C
|
A:ASP206
|
3.3
|
19.6
|
1.0
|
OD1
|
A:ASP131
|
3.4
|
16.2
|
1.0
|
CG
|
A:ASP206
|
3.6
|
26.7
|
1.0
|
C
|
A:GLU208
|
3.7
|
19.4
|
1.0
|
OG
|
A:SER129
|
3.7
|
19.5
|
1.0
|
CA
|
A:ASP206
|
3.8
|
19.5
|
1.0
|
CD1
|
A:TRP210
|
3.8
|
12.9
|
1.0
|
N
|
A:GLU208
|
4.2
|
18.7
|
1.0
|
CB
|
A:ASP206
|
4.3
|
22.8
|
1.0
|
OD2
|
A:ASP206
|
4.3
|
33.1
|
1.0
|
N
|
A:ASP207
|
4.3
|
17.1
|
1.0
|
C
|
A:ASP207
|
4.4
|
19.5
|
1.0
|
CB
|
A:ASP131
|
4.4
|
15.2
|
1.0
|
N
|
A:TRP210
|
4.5
|
15.8
|
1.0
|
NE1
|
A:TRP210
|
4.5
|
12.0
|
1.0
|
CA
|
A:LEU209
|
4.5
|
18.2
|
1.0
|
N
|
A:LEU209
|
4.6
|
19.1
|
1.0
|
CA
|
A:GLU208
|
4.6
|
18.1
|
1.0
|
CA
|
A:ASP207
|
4.6
|
19.3
|
1.0
|
CG
|
A:TRP210
|
4.8
|
12.8
|
1.0
|
CB
|
A:SER129
|
4.8
|
18.5
|
1.0
|
O
|
A:ASP207
|
4.9
|
19.8
|
1.0
|
O
|
A:ASP205
|
4.9
|
19.1
|
1.0
|
N
|
A:ASP131
|
4.9
|
18.1
|
1.0
|
|
Calcium binding site 4 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 4 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 4 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Ca449
b:40.4
occ:1.00
|
O
|
A:SER149
|
2.3
|
16.1
|
1.0
|
O
|
A:THR152
|
2.4
|
15.5
|
1.0
|
O
|
A:HOH532
|
2.4
|
20.0
|
1.0
|
O
|
A:HOH576
|
2.5
|
20.0
|
1.0
|
C
|
A:SER149
|
3.5
|
18.4
|
1.0
|
C
|
A:THR152
|
3.6
|
17.0
|
1.0
|
O
|
A:HOH598
|
4.1
|
28.9
|
1.0
|
N
|
A:THR152
|
4.1
|
16.8
|
1.0
|
CA
|
A:PRO153
|
4.3
|
19.6
|
1.0
|
C
|
A:ALA150
|
4.4
|
18.2
|
1.0
|
CA
|
A:SER149
|
4.4
|
17.2
|
1.0
|
N
|
A:PRO153
|
4.4
|
18.8
|
1.0
|
O
|
A:LEU154
|
4.4
|
13.7
|
1.0
|
N
|
A:ALA150
|
4.4
|
16.8
|
1.0
|
CA
|
A:ALA150
|
4.5
|
17.8
|
1.0
|
O
|
A:ALA150
|
4.5
|
18.3
|
1.0
|
CA
|
A:THR152
|
4.5
|
17.2
|
1.0
|
O
|
A:HOH599
|
4.6
|
32.4
|
1.0
|
CB
|
A:SER149
|
4.7
|
17.2
|
1.0
|
C
|
A:PRO153
|
4.8
|
19.4
|
1.0
|
N
|
A:VAL151
|
4.8
|
17.5
|
1.0
|
N
|
A:LEU154
|
4.9
|
17.6
|
1.0
|
|
Calcium binding site 5 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 5 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 5 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca446
b:20.8
occ:1.00
|
O
|
B:GLY183
|
2.2
|
19.0
|
1.0
|
OE2
|
B:GLU208
|
2.2
|
22.9
|
1.0
|
O
|
B:LEU187
|
2.3
|
20.1
|
1.0
|
O
|
B:ASP185
|
2.3
|
29.5
|
1.0
|
OD1
|
B:ASP182
|
2.3
|
16.6
|
1.0
|
OD2
|
B:ASP205
|
2.4
|
18.3
|
1.0
|
C
|
B:GLY183
|
3.4
|
22.3
|
1.0
|
CG
|
B:ASP205
|
3.4
|
17.6
|
1.0
|
C
|
B:LEU187
|
3.4
|
22.8
|
1.0
|
C
|
B:ASP185
|
3.4
|
29.4
|
1.0
|
CD
|
B:GLU208
|
3.4
|
21.7
|
1.0
|
CG
|
B:ASP182
|
3.5
|
21.7
|
1.0
|
N
|
B:LEU187
|
3.8
|
26.9
|
1.0
|
N
|
B:ASP185
|
3.9
|
28.3
|
1.0
|
N
|
B:GLY183
|
3.9
|
22.9
|
1.0
|
CB
|
B:ASP205
|
4.0
|
16.4
|
1.0
|
C
|
B:LYS184
|
4.1
|
27.7
|
1.0
|
OD2
|
B:ASP182
|
4.2
|
24.2
|
1.0
|
C
|
B:GLY186
|
4.2
|
27.8
|
1.0
|
CA
|
B:LEU187
|
4.2
|
26.1
|
1.0
|
CA
|
B:ASP185
|
4.2
|
30.2
|
1.0
|
CA
|
B:GLY183
|
4.2
|
21.7
|
1.0
|
C
|
B:ASP182
|
4.3
|
22.6
|
1.0
|
CG
|
B:GLU208
|
4.3
|
22.3
|
1.0
|
OE1
|
B:GLU208
|
4.3
|
21.2
|
1.0
|
OD1
|
B:ASP205
|
4.4
|
15.0
|
1.0
|
N
|
B:LYS184
|
4.4
|
22.7
|
1.0
|
N
|
B:ASP182
|
4.4
|
20.4
|
1.0
|
N
|
B:GLY186
|
4.4
|
28.1
|
1.0
|
N
|
B:LEU188
|
4.4
|
19.8
|
1.0
|
CA
|
B:LYS184
|
4.5
|
26.8
|
1.0
|
O
|
B:LYS184
|
4.5
|
27.1
|
1.0
|
CA
|
B:GLY186
|
4.5
|
27.4
|
1.0
|
CA
|
B:LEU188
|
4.6
|
17.9
|
1.0
|
CA
|
B:ASP182
|
4.6
|
20.7
|
1.0
|
CB
|
B:ASP182
|
4.6
|
21.3
|
1.0
|
O
|
B:GLY186
|
4.8
|
28.1
|
1.0
|
CB
|
B:LEU187
|
4.8
|
29.9
|
1.0
|
O
|
B:ASP182
|
4.8
|
21.2
|
1.0
|
|
Calcium binding site 6 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 6 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 6 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca447
b:26.0
occ:1.00
|
O
|
B:GLN199
|
2.3
|
18.9
|
1.0
|
OD1
|
B:ASP201
|
2.4
|
13.7
|
1.0
|
O
|
B:ASP165
|
2.5
|
17.3
|
1.0
|
O
|
B:GLY197
|
2.5
|
21.8
|
1.0
|
O
|
B:HOH508
|
2.7
|
11.3
|
1.0
|
CG
|
B:ASP201
|
3.4
|
17.4
|
1.0
|
C
|
B:GLN199
|
3.5
|
17.6
|
1.0
|
C
|
B:ASP165
|
3.6
|
16.7
|
1.0
|
C
|
B:GLY197
|
3.7
|
21.0
|
1.0
|
C
|
B:ILE198
|
3.9
|
21.0
|
1.0
|
OD2
|
B:ASP201
|
3.9
|
14.8
|
1.0
|
N
|
B:ASP201
|
4.0
|
16.1
|
1.0
|
O
|
B:ILE198
|
4.0
|
19.7
|
1.0
|
N
|
B:GLN199
|
4.1
|
19.6
|
1.0
|
O
|
B:ALA164
|
4.2
|
18.9
|
1.0
|
C
|
B:GLY200
|
4.3
|
16.4
|
1.0
|
CA
|
B:ILE198
|
4.3
|
22.1
|
1.0
|
N
|
B:GLY200
|
4.3
|
16.3
|
1.0
|
CA
|
B:GLY200
|
4.3
|
15.8
|
1.0
|
O
|
B:GLY195
|
4.4
|
20.1
|
1.0
|
O
|
B:HOH581
|
4.4
|
18.3
|
1.0
|
CA
|
B:ASP165
|
4.4
|
16.8
|
1.0
|
CA
|
B:GLN199
|
4.4
|
18.9
|
1.0
|
N
|
B:ILE198
|
4.5
|
21.5
|
1.0
|
N
|
B:ILE166
|
4.5
|
15.8
|
1.0
|
CB
|
B:ASP201
|
4.6
|
15.7
|
1.0
|
CG2
|
B:VAL167
|
4.6
|
10.7
|
1.0
|
N
|
B:VAL167
|
4.6
|
12.9
|
1.0
|
CA
|
B:ASP201
|
4.6
|
16.9
|
1.0
|
CA
|
B:ILE166
|
4.7
|
14.1
|
1.0
|
CA
|
B:GLY197
|
4.7
|
21.2
|
1.0
|
N
|
B:GLY197
|
4.8
|
20.3
|
1.0
|
CH2
|
B:TRP116
|
4.8
|
17.7
|
1.0
|
O
|
B:HOH582
|
4.9
|
30.3
|
1.0
|
C
|
B:PRO196
|
5.0
|
20.2
|
1.0
|
|
Calcium binding site 7 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 7 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 7 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca448
b:39.0
occ:1.00
|
O
|
B:GLU208
|
2.3
|
19.5
|
1.0
|
O
|
B:ASP206
|
2.4
|
15.0
|
1.0
|
O
|
B:HOH568
|
2.4
|
25.4
|
1.0
|
OD2
|
B:ASP131
|
2.4
|
14.6
|
1.0
|
OD1
|
B:ASP206
|
2.7
|
13.4
|
1.0
|
C
|
B:ASP206
|
3.3
|
15.0
|
1.0
|
CG
|
B:ASP131
|
3.3
|
14.1
|
1.0
|
C
|
B:GLU208
|
3.5
|
19.2
|
1.0
|
CG
|
B:ASP206
|
3.6
|
17.0
|
1.0
|
OD1
|
B:ASP131
|
3.6
|
13.8
|
1.0
|
CA
|
B:ASP206
|
3.8
|
15.1
|
1.0
|
OG
|
B:SER129
|
3.9
|
15.1
|
1.0
|
N
|
B:GLU208
|
4.0
|
19.1
|
1.0
|
CD1
|
B:TRP210
|
4.1
|
13.0
|
1.0
|
CB
|
B:ASP206
|
4.2
|
14.9
|
1.0
|
CA
|
B:LEU209
|
4.3
|
14.5
|
1.0
|
N
|
B:LEU209
|
4.3
|
17.0
|
1.0
|
N
|
B:ASP207
|
4.3
|
16.6
|
1.0
|
C
|
B:ASP207
|
4.3
|
19.9
|
1.0
|
OD2
|
B:ASP206
|
4.4
|
20.4
|
1.0
|
CA
|
B:GLU208
|
4.4
|
20.4
|
1.0
|
N
|
B:TRP210
|
4.6
|
14.7
|
1.0
|
CA
|
B:ASP207
|
4.6
|
18.4
|
1.0
|
NE1
|
B:TRP210
|
4.7
|
14.1
|
1.0
|
CB
|
B:ASP131
|
4.7
|
14.9
|
1.0
|
O
|
B:ASP207
|
4.9
|
20.8
|
1.0
|
C
|
B:LEU209
|
4.9
|
15.4
|
1.0
|
|
Calcium binding site 8 out
of 8 in 2ow1
Go back to
Calcium Binding Sites List in 2ow1
Calcium binding site 8 out
of 8 in the Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor
Mono view
Stereo pair view
|
A full contact list of Calcium with other atoms in the Ca binding
site number 8 of Mmp-9 Active Site Mutant with Trifluoromethyl Hydroxamate Inhibitor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Ca449
b:45.0
occ:1.00
|
O
|
B:THR152
|
2.2
|
23.7
|
1.0
|
O
|
B:SER149
|
2.3
|
19.6
|
1.0
|
O
|
B:HOH543
|
2.5
|
14.6
|
1.0
|
O
|
B:HOH583
|
2.5
|
26.8
|
1.0
|
C
|
B:THR152
|
3.4
|
24.4
|
1.0
|
C
|
B:SER149
|
3.5
|
19.0
|
1.0
|
CA
|
B:PRO153
|
4.1
|
26.4
|
1.0
|
N
|
B:THR152
|
4.2
|
24.4
|
1.0
|
N
|
B:PRO153
|
4.2
|
26.4
|
1.0
|
O
|
B:HOH599
|
4.3
|
44.9
|
1.0
|
O
|
B:LEU154
|
4.3
|
21.2
|
1.0
|
O
|
B:ALA150
|
4.4
|
22.8
|
1.0
|
CA
|
B:SER149
|
4.4
|
18.6
|
1.0
|
CA
|
B:THR152
|
4.4
|
24.1
|
1.0
|
C
|
B:ALA150
|
4.4
|
22.7
|
1.0
|
N
|
B:ALA150
|
4.5
|
19.9
|
1.0
|
C
|
B:PRO153
|
4.5
|
24.8
|
1.0
|
CA
|
B:ALA150
|
4.6
|
21.3
|
1.0
|
CB
|
B:SER149
|
4.8
|
15.4
|
1.0
|
N
|
B:LEU154
|
4.8
|
23.3
|
1.0
|
N
|
B:VAL151
|
4.9
|
23.3
|
1.0
|
|
Reference:
A.Tochowicz,
K.Maskos,
R.Huber,
R.Oltenfreiter,
V.Dive,
A.Yiotakis,
M.Zanda,
W.Bode,
P.Goettig.
Crystal Structures of Mmp-9 Complexes with Five Inhibitors: Contribution of the Flexible ARG424 Side-Chain to Selectivity. J.Mol.Biol. V. 371 989 2007.
ISSN: ISSN 0022-2836
PubMed: 17599356
DOI: 10.1016/J.JMB.2007.05.068
Page generated: Fri Jul 12 14:47:20 2024
|