Calcium in PDB 2ppl: Human Pancreatic Lipase-Related Protein 1

All present enzymatic activity of Human Pancreatic Lipase-Related Protein 1:
3.1.1.3;

The structure of Human Pancreatic Lipase-Related Protein 1, PDB code: 2ppl was solved by J.R.Walker, T.Davis, A.Seitova, C.Butler-Cole, J.Weigelt, M.Sundstrom, C.H.Arrowsmith, A.M.Edwards, A.Bochkarev, S.Dhe-Paganon, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.92 / 2.20
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	62.871, 62.871, 306.280, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 23.3

The structure of Human Pancreatic Lipase-Related Protein 1 also contains other interesting chemical elements:

Sodium

(Na)

3 atoms

The binding sites of Calcium atom in the Human Pancreatic Lipase-Related Protein 1 (pdb code 2ppl). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Human Pancreatic Lipase-Related Protein 1, PDB code: 2ppl:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Human Pancreatic Lipase-Related Protein 1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Pancreatic Lipase-Related Protein 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca478 b:44.1 occ:1.00 OD1 A:ASP210 2.2 49.0 1.0 O A:HOH581 2.3 46.1 1.0 O A:GLU205 2.3 55.5 0.5 O A:HOH538 2.3 44.3 1.0 O A:GLU205 2.3 55.4 0.5 O A:ARG208 2.3 46.6 1.0 OD1 A:ASP213 2.4 46.9 1.0 OD2 A:ASP213 2.5 46.6 1.0 CG A:ASP213 2.8 45.6 1.0 CG A:ASP210 3.4 46.4 1.0 C A:GLU205 3.5 53.4 0.5 C A:GLU205 3.5 53.3 0.5 C A:ARG208 3.5 45.5 1.0 N A:ASP210 3.9 41.8 1.0 CB A:ASP210 4.1 44.0 1.0 O A:HOH522 4.2 51.5 1.0 C A:LEU209 4.2 42.2 1.0 CA A:LEU209 4.3 41.9 1.0 CB A:ASP213 4.3 44.7 1.0 OD2 A:ASP210 4.3 45.7 1.0 N A:LEU209 4.4 43.2 1.0 CA A:GLU205 4.4 53.2 0.5 CA A:GLU205 4.4 53.2 0.5 N A:GLU206 4.4 53.5 1.0 N A:ARG208 4.4 46.9 1.0 O A:GLY178 4.4 47.6 1.0 O A:HOH498 4.4 45.7 1.0 C A:GLU206 4.5 53.2 1.0 CA A:GLU206 4.5 55.5 1.0 O A:GLU206 4.6 56.2 1.0 CA A:ARG208 4.6 44.9 1.0 CA A:ASP210 4.6 43.0 1.0 C A:GLY178 4.7 47.2 1.0 CB A:GLU205 4.7 52.9 0.5 CB A:GLU205 4.7 52.9 0.5 CB A:SER182 4.8 49.8 1.0 CA A:GLY178 4.9 45.9 1.0 O A:ASP210 4.9 44.9 1.0 O A:LEU209 4.9 42.8 1.0

Calcium binding site 2 out of 3 in the Human Pancreatic Lipase-Related Protein 1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Pancreatic Lipase-Related Protein 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca481 b:53.0 occ:1.00 OD1 A:ASN421 2.4 49.0 1.0 O A:ASN422 2.5 51.7 1.0 OE2 A:GLU458 2.7 64.5 1.0 CG A:ASN421 3.3 48.4 1.0 CD A:GLU458 3.5 54.0 1.0 C A:ASN422 3.7 53.1 1.0 ND2 A:ASN421 3.7 46.0 1.0 CG A:GLU458 3.9 50.4 1.0 N A:ASN422 4.0 50.7 1.0 CA A:CA482 4.0 48.1 1.0 OE1 A:GLU458 4.4 55.1 1.0 OD1 A:ASN422 4.4 53.1 1.0 CA A:ASN422 4.5 49.9 1.0 OD2 A:ASP459 4.5 69.7 1.0 CB A:ASN421 4.7 46.4 1.0 N A:ASN423 4.7 53.7 1.0 OD1 A:ASN423 4.8 56.3 1.0 CA A:ASN421 4.8 47.6 1.0 CA A:ASN423 4.9 57.5 1.0 C A:ASN421 4.9 48.2 1.0 CB A:ASP459 4.9 56.5 1.0

Calcium binding site 3 out of 3 in the Human Pancreatic Lipase-Related Protein 1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human Pancreatic Lipase-Related Protein 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca482 b:48.1 occ:1.00 OD1 A:ASN426 2.3 61.7 1.0 OD1 A:ASN422 2.3 53.1 1.0 O A:VAL424 2.4 60.1 1.0 OE2 A:GLU458 2.4 64.5 1.0 O A:HOH607 2.4 46.9 1.0 OE1 A:GLU458 2.5 55.1 1.0 CD A:GLU458 2.8 54.0 1.0 CG A:ASN422 3.4 52.5 1.0 CG A:ASN426 3.5 64.3 1.0 C A:VAL424 3.6 61.5 1.0 ND2 A:ASN422 3.8 52.1 1.0 O A:ASN422 3.9 51.7 1.0 CA A:CA481 4.0 53.0 1.0 N A:ASN426 4.0 62.9 1.0 CB A:ASN426 4.2 63.2 1.0 N A:VAL424 4.2 61.1 1.0 O A:HOH602 4.2 46.2 1.0 CG A:GLU458 4.3 50.4 1.0 C A:ASN422 4.4 53.1 1.0 CA A:ILE425 4.4 62.5 1.0 N A:ILE425 4.4 62.0 1.0 C A:ILE425 4.5 62.3 1.0 ND2 A:ASN426 4.5 62.4 1.0 CA A:VAL424 4.6 62.9 1.0 CB A:ASN422 4.7 51.6 1.0 CA A:ASN426 4.7 63.2 1.0 CA A:ASN422 4.9 49.9 1.0 N A:ASN422 4.9 50.7 1.0 N A:ASN423 4.9 53.7 1.0

J.R.Walker, T.Davis, A.Seitova, C.Butler-Cole, J.Weigelt, M.Sundstrom, C.H.Arrowsmith, A.M.Edwards, A.Bochkarev, S.Dhe-Paganon. Structure of the Human Pancreatic Lipase-Related Protein 1. To Be Published.