Calcium in PDB 2pvs: Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q

All present enzymatic activity of Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q:
3.1.1.3;

The structure of Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q, PDB code: 2pvs was solved by S.Spinelli, C.Eydoux, F.Carriere, C.Cambillau, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.18 / 3.00
Space group	I 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	216.181, 216.181, 123.672, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 24.9

The binding sites of Calcium atom in the Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q (pdb code 2pvs). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q, PDB code: 2pvs:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca502 b:50.6 occ:1.00 O A:GLU187 2.3 53.4 1.0 OD2 A:ASP192 2.3 42.9 1.0 O A:ARG190 2.4 48.6 1.0 OD1 A:ASP195 2.6 51.9 1.0 OD2 A:ASP195 2.7 47.5 1.0 CG A:ASP195 3.0 48.0 1.0 C A:GLU187 3.4 53.5 1.0 C A:ARG190 3.6 47.9 1.0 CG A:ASP192 3.6 46.6 1.0 O A:GLU188 4.1 53.6 1.0 C A:GLU188 4.2 53.4 1.0 N A:ARG190 4.2 49.5 1.0 CA A:GLU188 4.2 54.0 1.0 N A:GLU188 4.3 53.6 1.0 O A:ALA159 4.3 50.0 1.0 N A:ASP192 4.3 46.1 1.0 CA A:GLU187 4.4 53.7 1.0 OD1 A:ASP192 4.4 47.7 1.0 N A:LEU191 4.5 47.0 1.0 CB A:ASP192 4.5 46.3 1.0 CA A:ARG190 4.5 48.8 1.0 CB A:ASP195 4.5 46.6 1.0 CA A:LEU191 4.5 46.4 1.0 C A:LEU191 4.5 46.3 1.0 CD A:ARG163 4.5 46.7 1.0 OG A:SER194 4.6 44.5 1.0 CB A:GLU187 4.6 53.5 1.0 CB A:ALA159 4.7 49.1 1.0 CB A:ARG163 4.8 48.0 1.0 N A:VAL189 4.8 52.5 1.0 CG A:ARG163 4.9 47.4 1.0 CA A:ASP192 5.0 46.1 1.0

Calcium binding site 2 out of 2 in the Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Human Pancreatic Lipase Related Protein 2 Mutant N336Q within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca501 b:43.1 occ:1.00 OD2 B:ASP192 2.1 44.5 1.0 O B:ARG190 2.3 48.2 1.0 O B:GLU187 2.4 53.4 1.0 O B:HOH511 2.4 36.9 1.0 OD2 B:ASP195 2.5 49.2 1.0 OD1 B:ASP195 2.7 53.4 1.0 CG B:ASP195 3.0 48.9 1.0 CG B:ASP192 3.4 46.7 1.0 C B:ARG190 3.5 48.4 1.0 C B:GLU187 3.5 53.1 1.0 N B:ASP192 4.1 46.4 1.0 OD1 B:ASP192 4.2 46.4 1.0 CA B:GLU187 4.2 53.1 1.0 C B:LEU191 4.2 47.1 1.0 N B:ARG190 4.3 49.7 1.0 N B:LEU191 4.3 47.6 1.0 CB B:ASP192 4.3 46.3 1.0 CB B:GLU187 4.4 53.2 1.0 O B:GLU188 4.4 52.8 1.0 CB B:ALA159 4.4 50.5 1.0 CA B:LEU191 4.4 47.2 1.0 O B:ALA159 4.4 50.4 1.0 CA B:ARG190 4.5 49.2 1.0 CB B:ASP195 4.5 47.0 1.0 N B:GLU188 4.5 53.1 1.0 C B:GLU188 4.6 53.0 1.0 OG B:SER194 4.6 46.1 1.0 CD B:ARG163 4.7 49.2 1.0 CB B:ARG163 4.7 48.8 1.0 CA B:GLU188 4.8 53.8 1.0 CA B:ASP192 4.8 46.1 1.0 O B:ASP192 4.8 46.3 1.0 O B:LEU191 4.8 47.0 1.0 C B:ALA159 5.0 50.6 1.0 CG B:ARG163 5.0 48.7 1.0

C.Eydoux, S.Spinelli, T.L.Davis, J.R.Walker, A.Seitova, S.Dhe-Paganon, A.De Caro, C.Cambillau, F.Carriere. Structure of Human Pancreatic Lipase-Related Protein 2 with the Lid in An Open Conformation. Biochemistry V. 47 9553 2008.
ISSN: ISSN 0006-2960
PubMed: 18702514
DOI: 10.1021/BI8005576