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Calcium in PDB 2pvv: Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate

Enzymatic activity of Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate

All present enzymatic activity of Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate:
3.4.17.21;

Protein crystallography data

The structure of Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate, PDB code: 2pvv was solved by C.Barinka, J.Lubkowski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.11
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.617, 130.220, 158.975, 90.00, 90.00, 90.00
R / Rfree (%) 17.4 / 21.2

Other elements in 2pvv:

The structure of Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Zinc (Zn) 2 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate (pdb code 2pvv). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate, PDB code: 2pvv:

Calcium binding site 1 out of 1 in 2pvv

Go back to Calcium Binding Sites List in 2pvv
Calcium binding site 1 out of 1 in the Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with L-Serine-O-Sulfate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1753

b:16.9
occ:1.00
 O A:TYR272 2.3 17.9 1.0
OE2 A:GLU436 2.4 16.8 1.0
O A:THR269 2.4 18.0 1.0
OE1 A:GLU433 2.4 17.1 1.0
O A:HOH1774 2.4 19.5 1.0
OE2 A:GLU433 2.5 16.8 1.0
OG1 A:THR269 2.5 17.7 1.0
CD A:GLU433 2.8 15.3 1.0
C A:THR269 3.3 17.7 1.0
C A:TYR272 3.4 16.9 1.0
CB A:THR269 3.4 16.8 1.0
CD A:GLU436 3.4 15.8 1.0
OE1 A:GLU436 3.9 14.7 1.0
CA A:THR269 4.0 17.1 1.0
N A:TYR272 4.0 17.2 1.0
CB A:ASP266 4.2 18.4 1.0
N A:ALA274 4.2 19.3 1.0
CA A:PRO273 4.2 18.4 1.0
N A:PRO273 4.2 16.9 1.0
N A:PRO270 4.3 18.2 1.0
CG A:GLU433 4.3 14.3 1.0
CA A:TYR272 4.3 17.1 1.0
O A:ASP266 4.4 18.8 1.0
C A:PRO273 4.5 19.5 1.0
CA A:PRO270 4.5 17.3 1.0
N A:ASP266 4.5 19.5 1.0
N A:GLY271 4.5 17.5 1.0
O A:ALA264 4.6 20.4 1.0
N A:THR269 4.7 18.2 1.0
CG A:GLU436 4.7 16.6 1.0
C A:PRO270 4.7 17.9 1.0
CG2 A:THR269 4.8 15.4 1.0
OD2 A:ASP266 4.8 21.2 1.0
CA A:ASP266 4.8 19.2 1.0
CB A:GLU436 4.9 16.6 1.0
CA A:GLU433 4.9 15.6 1.0
CB A:ALA274 4.9 19.6 1.0
C A:GLY271 5.0 16.4 1.0

Reference:

C.Barinka, M.Rovenska, P.Mlcochova, K.Hlouchova, A.Plechanovova, P.Majer, T.Tsukamoto, B.S.Slusher, J.Konvalinka, J.Lubkowski. Structural Insight Into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II. J.Med.Chem. V. 50 3267 2007.
ISSN: ISSN 0022-2623
PubMed: 17567119
DOI: 10.1021/JM070133W
Page generated: Fri Jul 12 15:18:04 2024

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